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SBRT without ADT in selected age groupings.

User
Posted 25 May 2025 at 03:21

 


Thanks for the on topic posts.


Topic is now closed.

Edited by member 28 May 2025 at 23:12  | Reason: academic

User
Posted 25 May 2025 at 19:48

I think there have been a few trials now which show hormone therapy reduces recurrence after prostatectomy.


I've never seen this rolled out in practice though. I think this may be due to prostatectomy surgeon's optimism that they will cure each case, combined with hormone therapy really being an oncology treatment rather more than a urology treatment.


I don't think anyone fully understands how/why hormone therapy works. The best I've heard is speculation from a clinical and research oncologist who says the data matches a scenario whereby zapping the mothership and then keeping tiny (unknown/undiagnosed) mets suppressed for at least 18 months afterwards would seem to prevent them coming back afterwards to cause recurrence.


If it is that, then hormone therapy should be just as effective with prostatectomies. Given that currently 32% of prostatectomies have recurrence afterwards, this is something that should be discussed with patients, but it's not currenely offered on the NHS (or anywhere else as far as I know).

User
Posted 28 May 2025 at 02:37

Reply to microcolei


I am broadly in agreement with most of what you wrote.


In Australia SBRT is certainly gaining traction as a viable treatment for a recurrence. It has been around for about 5 years plus. Treating physicians took a while to come on board as with any new technology. The pro is the precise nature of the targeted therapy. The con is that whilst effective focally micro mets continue to flourish albeit with a reduced rate as a consequence. Thus whilst not definitively curative, the quality of life window is substantially enhanced. The timely introduction of therapy is critical for optimal outcome. In Australia SBRT can treat up to five lesions (be they node, bony or visceral) but can be repeated as required. I know several men who have had multiple sessions of SBRT over the years and have done well.


 

User
Posted 28 May 2025 at 16:41

Originally Posted by: Online Community Member
Upon reflection I have decided to respond to on topic posters.


Have you any idea how condescending that sounds? Something a pompous teacher would say.


I see you've marked the class homework.


Andy62:   10/10 + gold star.


Microcolei:   8/10


Colwick Chris:  7/10


Francij1:  6/10


Adrian56:  Ungraded and sent to Coventry. 


😁

Edited by member 28 May 2025 at 19:09  | Reason: Typo

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User
Posted 25 May 2025 at 11:07

Hi jfd


Following my RARP, two years ago, when I was T3a, EPE, Gleason 9(4+5), nonograms suggest that I have a high chance of BCR. So this is of particular interest to me.


Recently in the UK, SBRT has started to be used as a primary radical treatment, requiring only 5 sessions. Had it been available to me, I may have chosen it over surgery.


I've often asked whether it could be used as salvage treatment, but was lead to believe, not as yet.


The most recent peer reviewed research I could find was this:


https://pmc.ncbi.nlm.nih.gov/articles/PMC8833497/


Which concluded:


At this point, ultra-hypofractionated RT using SBRT to the prostate bed remains experimental and its use should be restricted to clinical trials. Given the biological rationale for extreme hypofractionation in patients with prostate cancer and the acceptable toxicity rates that have been reported, further exploration of this field is warranted.


If you have a link to any other more up to do research. I'd be grateful if you could send a link.


 

User
Posted 25 May 2025 at 12:47

This is a standard of care in England (I'm not aware that's it's offered in the other UK countries).


Stereotactic ablative radiotherapy (SABR) for patients with metachronous extracranial oligometastatic cancer (all ages) (URN: 1908) [200205P]


The issue of ADT or not isn't addressed here - it's up to the oncologist and patient to decide.


Sadly, centres without PSMA PET scanning and SABR almost never think to offer this, so many patients have missed out on this treatment which they should have been offered.


 

User
Posted 25 May 2025 at 13:17

Jfd, you say recurrence after treatment it may help to clarify which treatment, I had the educated guess VMAT salvage radiation treatment without HT after RARP. I then had SABR treatment without HT to a single cancerous lymph node. This was followed by further SABR with Bicalutamide to another lymph node. I did say at the time I was probably chasing the end of the rainbow. I have found it strange that the rate of rise my PSA has significantly increased since having the scans and SABR treatments and I am now on HT probably for life.


Thanks Chris 


 

User
Posted 25 May 2025 at 13:30

Slightly off thread. Due to the uncertainty of my suitability for surgery, whilst urology and cardiology were getting their heads together, I was put on bical for a couple of months, whilst they decided what they were going to do with me.


As I said, with capsular breach and a high Gleason I feared BCR. Recently I was trawling time peer reviewed research which suggested that HT prior to surgery reduced the risk of recurrence. I'll try and find it and put on a link.

User
Posted 25 May 2025 at 18:58
I think there is an assumption that HT only puts cancer to sleep. When I discussed my perception of this with my oncologist she said that HT does kill some metastasis completely on its own. She evidenced this with her experience of patients with multiple metastasis who receive intermittent HT. She stated that some metastasis disappear with HT and do not come back when the HT is suspended.

User
Posted 25 May 2025 at 19:48

I think there have been a few trials now which show hormone therapy reduces recurrence after prostatectomy.


I've never seen this rolled out in practice though. I think this may be due to prostatectomy surgeon's optimism that they will cure each case, combined with hormone therapy really being an oncology treatment rather more than a urology treatment.


I don't think anyone fully understands how/why hormone therapy works. The best I've heard is speculation from a clinical and research oncologist who says the data matches a scenario whereby zapping the mothership and then keeping tiny (unknown/undiagnosed) mets suppressed for at least 18 months afterwards would seem to prevent them coming back afterwards to cause recurrence.


If it is that, then hormone therapy should be just as effective with prostatectomies. Given that currently 32% of prostatectomies have recurrence afterwards, this is something that should be discussed with patients, but it's not currenely offered on the NHS (or anywhere else as far as I know).

User
Posted 26 May 2025 at 00:15

Originally Posted by: Online Community Member
Given that ADT in this age group may cause considerable strain on quality of life, this has given rise to considerable discussion and revaluation. Consequently I would be interested in hearing from forum members who have been treated for a recurrence with SBRT.


I'm guessing the focus of your question is the above quote and that you are thinking in terms of your own treatment where SBRT was used to treat recurrence some 16 years after your initial EBRT and ADT. Your post raises enough questions to set up a thread for follow up replies to all of them, though it's going to be hard to find people out there who've had this SBRT treatment and the time to evaluate it in terms of clinical outcomes.


In terms of QoL, presumably ADT on the 70+ age group would be much the same as it is for those of the same age who've had EBRT as a primary treatment, along with 18mth to 3 years of ADT, would it not? There's been considerable amounts of discussion here about that but it's so variable between different people. Many 70+ people have various co-morbidities and might not have been likely to live for say 10 years, while others could have kicked on for 30. On top of that, while it might not be clinically recognized, the effect of ADT on QoL varies considerably from one person to another. The rather ambiguous clinical term "tolerance" can imply that a person who suffers badly from ADT, does so because of some personal weakness.


As far as using SBRT as an option for treating recurrence in preference to other possibilities, what are your own views?


Jules


 

Edited by member 26 May 2025 at 01:29  | Reason: Not specified

User
Posted 28 May 2025 at 01:51

Reply to Andy62


Do you have any figures/% of centres in the UK offering PSMA Pet Scan?

Edited by member 28 May 2025 at 01:52  | Reason: Not specified

User
Posted 28 May 2025 at 01:59

Reply to Colwickchris


The usual treatments following diagnosis.


 

User
Posted 28 May 2025 at 02:03

Reply to francij1


Considerable debate in academic circles over this issue. Decrease in activity is well documented and accepted. Eradication subject to conjecture. Plus we can also throw personal experience into the mix as well.

User
Posted 28 May 2025 at 02:37

Reply to microcolei


I am broadly in agreement with most of what you wrote.


In Australia SBRT is certainly gaining traction as a viable treatment for a recurrence. It has been around for about 5 years plus. Treating physicians took a while to come on board as with any new technology. The pro is the precise nature of the targeted therapy. The con is that whilst effective focally micro mets continue to flourish albeit with a reduced rate as a consequence. Thus whilst not definitively curative, the quality of life window is substantially enhanced. The timely introduction of therapy is critical for optimal outcome. In Australia SBRT can treat up to five lesions (be they node, bony or visceral) but can be repeated as required. I know several men who have had multiple sessions of SBRT over the years and have done well.


 

User
Posted 28 May 2025 at 10:59

Originally Posted by: Online Community Member


Reply to Andy62


Do you have any figures/% of centres in the UK offering PSMA Pet Scan?



Not figures.


PSMA PET scans were already available privately in the UK before 2018 when I was diagnosed - all sizable private centres had the capability. They've cost about £2,500 privately since 2018 (so in real terms, they've got cheaper).


The Paul Strictland Scanner Centre (co-located with Mount Vernon Cancer Centre in the UK) started offering PSMA PET scans on the NHS by the end of 2018 (which I've heard was the first to do so), and this became more standard there on the NHS in 2019. I suspect that by the end of 2019, all the major NHS cancer centres were offering them. One of my support groups had a talk in 2019 where MVCC said they'd switched from Technetium 99m bone scans over to PSMA PET scans, having found them much more accurate. (However, MVCC are mainly a tertiary care centre - most of their patients have already had their scans and been diagnosed before referral there for treatment, they don't directly diagnose many of their patients themselves.) They were only still doing Technetium 99m bone scans in the case of patients on trials where this was part of the trial protocol.


Increasingly, I am seeing PSMA PET scanning available at the larger district general hospitals now too so things are improving, but many still don't have the capability. In theory, those can refer patients elsewhere for scans, but that's much less likely to happen. I was talking about this with a oncology radiologist who does PET scanning. They said the hospitals without the capability on site just don't have oncologists who are familiar with PET scans for diagnostics. They see patients who pay for a private PSMA PET scan elsewhere, take the report back to their NHS oncologist, who then doesn't really know what to do with it. So if you are at a cancer stage where these scans are particularly important (such as recurrence, or a particularly risky/tricky initial diagnosis), you probably do better to be referred to a hospital which has its own PSMA PET scanning (and SABR) service, where you are more likely to get the appropriate diagnosis and treatments.


The US was notably late in adopting and rolling out PSMA PET scans. They didn't get FDA approval until 2020.

User
Posted 28 May 2025 at 14:09

Reply to Andy 62


Thank you for your post and you do raise one very salient issue. PSMA Pet Scan availability is one issue. The other is the considerable skill required by the Consultant Physician/s in reading them more often than not requiring other validations for comparison.  

User
Posted 28 May 2025 at 16:41

Originally Posted by: Online Community Member
Upon reflection I have decided to respond to on topic posters.


Have you any idea how condescending that sounds? Something a pompous teacher would say.


I see you've marked the class homework.


Andy62:   10/10 + gold star.


Microcolei:   8/10


Colwick Chris:  7/10


Francij1:  6/10


Adrian56:  Ungraded and sent to Coventry. 


😁

Edited by member 28 May 2025 at 19:09  | Reason: Typo

 
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