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User
Posted 02 Jun 2025 at 12:05

I’ve just had my 3 monthly prostap injection also on 240 mg of apalalutamide any body else feel worse for a few days after the injection Iam still at work but struggling with muscle pain and feeling tired

User
Posted 02 Jun 2025 at 12:05

I’ve just had my 3 monthly prostap injection also on 240 mg of apalalutamide any body else feel worse for a few days after the injection Iam still at work but struggling with muscle pain and feeling tired

User
Posted 03 Jun 2025 at 10:55

Hi David. 


I'm afraid I can't help with this one, but I'm bumping the thread, in case others can.

Edited by member 16 Jul 2025 at 07:42  | Reason: Typo

User
Posted 07 Jun 2025 at 14:15
Hi David

I am just at the end of 2 years of Hormone therapy. Prostap 11.25mg injection every 12 weeks. My last jab (ever I hope) was in February 2025.

Good news - my cancer (which was high risk, 4+4 Gleason 8 and TB3N0M0) is under control at the moment (also had 20 sessions of EBRT at the begining of 2024)

Not so good news - I would feel worse for a week or so after each injection. As time went on the side effects also generally became more difficult to manage and were more severe (for me that included fatigue, flushes, joint pain, the sexual stuff (no libido/ED) and muscle pain.

I am not yet benefitting hugely from stopping the medication but flushes are a little less fierce, energy seems a little recovered and just about to start some exercise rehabilitation. The worse for me, which has not recovered at all as yet - is joint pain.

I worked full time all through my treatment (not a wise choice but I bet a lot of us do it) During my second year of treatment i would arrange for my injection to be late afternoon and take a day or two leave after the injection - and that helped. I was also lucky to have a supportive employer who lets me (still) take time away when my fatigue gets too much - eg the odd hour or sometimes half day. I found that really helped - both because I wasn't worrying all day what i would do if my energy faltered, but also to allow me to look after myself a little better.

I hope some of the above helps you with your situation, even if it is just that you are not alone at having more intense side effects straight after an injection.

Good luck, mate - I hope your recovery goes well.

And thanks for bumping Adrian56 - I did wonder if I was imagining the injection effect and seeing this post makes me feel a bit better.
User
Posted 15 Jul 2025 at 16:22

Hi Dave,


I'm a fellow Prostap sufferer, I've just got past 2 (out of 3) years on the stuff and my desperation is such that I've been pleading to come off it. My Oncologist recently sent me a sobering response, to remind me why I was prescribed it in the first place, to reduce the risk of the PCa returning, in fact she said that it was high risk whether I was on it or not! She did say that she didn't have any objections if I chose to stop, so the ball is in my court - a question then of how much longer can I last on it. And if I stop, will I regret it especially if it does return? 


The recent hot weather seems to have exacerbated my hot sweats, a proper nightmare. I feel them starting up every 2 hours and worse at night. The various side effects seem to compete with each other for title of biggest drag on my life and they all get a turn at various times. Currently, fatigue is wiping me out and I frequently can't be arsed doing anything except go to sleep. And when I have a few beers or wine then I'm often knocked out the next day. 


Anyway, interesting that you get an impact from the injection itself, that is not something that I have noticed at all. At worse I've had a 'wasp sting' type pain at the site a couple of days after but that is it.


Full admiration for anyone carrying on working, I would have it impossible for me to continue my job, I struggle to get up in the morning! Fortunately, I think I can just about make it financially, well I could if my kids weren't leaching me dry, but I'm past caring on that front.


All the best 


Spongebob

User
Posted 15 Jul 2025 at 18:08

Hi Adria n,


Thanks - yes it's a struggle every which way isn't it. It was Japan, I have to pinch myself to believe that we actually went - it was incredible. So much so that me and the missus are going to China next year! 😁.


Ben More was a challenge, thought I was going to die. It makes me realise just how fit I was before all this started. 


Best keep going, just get on with it. 


Was up in Richmond, North Yorks, over the weekend, met up with an old school mate, good to have a few social beers and a good chin wag. Also, yes, caught some of the cricket - fantastic. I don't do golf though. Tour de France is keeping me going.


Cheers


Spongebob

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User
Posted 03 Jun 2025 at 10:55

Hi David. 


I'm afraid I can't help with this one, but I'm bumping the thread, in case others can.

Edited by member 16 Jul 2025 at 07:42  | Reason: Typo

User
Posted 07 Jun 2025 at 14:15
Hi David

I am just at the end of 2 years of Hormone therapy. Prostap 11.25mg injection every 12 weeks. My last jab (ever I hope) was in February 2025.

Good news - my cancer (which was high risk, 4+4 Gleason 8 and TB3N0M0) is under control at the moment (also had 20 sessions of EBRT at the begining of 2024)

Not so good news - I would feel worse for a week or so after each injection. As time went on the side effects also generally became more difficult to manage and were more severe (for me that included fatigue, flushes, joint pain, the sexual stuff (no libido/ED) and muscle pain.

I am not yet benefitting hugely from stopping the medication but flushes are a little less fierce, energy seems a little recovered and just about to start some exercise rehabilitation. The worse for me, which has not recovered at all as yet - is joint pain.

I worked full time all through my treatment (not a wise choice but I bet a lot of us do it) During my second year of treatment i would arrange for my injection to be late afternoon and take a day or two leave after the injection - and that helped. I was also lucky to have a supportive employer who lets me (still) take time away when my fatigue gets too much - eg the odd hour or sometimes half day. I found that really helped - both because I wasn't worrying all day what i would do if my energy faltered, but also to allow me to look after myself a little better.

I hope some of the above helps you with your situation, even if it is just that you are not alone at having more intense side effects straight after an injection.

Good luck, mate - I hope your recovery goes well.

And thanks for bumping Adrian56 - I did wonder if I was imagining the injection effect and seeing this post makes me feel a bit better.
User
Posted 15 Jul 2025 at 16:22

Hi Dave,


I'm a fellow Prostap sufferer, I've just got past 2 (out of 3) years on the stuff and my desperation is such that I've been pleading to come off it. My Oncologist recently sent me a sobering response, to remind me why I was prescribed it in the first place, to reduce the risk of the PCa returning, in fact she said that it was high risk whether I was on it or not! She did say that she didn't have any objections if I chose to stop, so the ball is in my court - a question then of how much longer can I last on it. And if I stop, will I regret it especially if it does return? 


The recent hot weather seems to have exacerbated my hot sweats, a proper nightmare. I feel them starting up every 2 hours and worse at night. The various side effects seem to compete with each other for title of biggest drag on my life and they all get a turn at various times. Currently, fatigue is wiping me out and I frequently can't be arsed doing anything except go to sleep. And when I have a few beers or wine then I'm often knocked out the next day. 


Anyway, interesting that you get an impact from the injection itself, that is not something that I have noticed at all. At worse I've had a 'wasp sting' type pain at the site a couple of days after but that is it.


Full admiration for anyone carrying on working, I would have it impossible for me to continue my job, I struggle to get up in the morning! Fortunately, I think I can just about make it financially, well I could if my kids weren't leaching me dry, but I'm past caring on that front.


All the best 


Spongebob

User
Posted 15 Jul 2025 at 17:39

Hi Spongebob ,


Your energy has always amazed me. Your holidaying in Japan and was it France? would have tired me out. I also recall you climbed Ben More recently, which I wouldn't have even attempted. So, I think, you're doing brilliantly.


I know Prostap can have side effects, but I'm wondering if this is more of a psychological issue. I recently started a conversation showing that ADT can also detrimentally affect your mental health.


https://community.prostatecanceruk.org/posts/t31833-Mental-health-issues-caused-by-hormone-therapy


I'm not on any HT, but like you, I get good days and bad days. I often feel completely unmotivated, exhausted and can hardly drag myself our of bed. I put this down to coping with PCa. I think dealing with the disease, whether or not you're on ADT can become, even subconsciously, very tiring.


I suppose hormone therapy produces side effects of it's own, which can only exacerbate this fatigue.


All I'm trying to say, mate, is I was once very fit, but dealing with this disease, even without HT, has certainly taken it toll on me.


I'm half the man I used to be, and that's just not penis length related. 🙂

Edited by member 16 Jul 2025 at 07:46  | Reason: Add link

User
Posted 15 Jul 2025 at 18:08

Hi Adria n,


Thanks - yes it's a struggle every which way isn't it. It was Japan, I have to pinch myself to believe that we actually went - it was incredible. So much so that me and the missus are going to China next year! 😁.


Ben More was a challenge, thought I was going to die. It makes me realise just how fit I was before all this started. 


Best keep going, just get on with it. 


Was up in Richmond, North Yorks, over the weekend, met up with an old school mate, good to have a few social beers and a good chin wag. Also, yes, caught some of the cricket - fantastic. I don't do golf though. Tour de France is keeping me going.


Cheers


Spongebob

 
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