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PSA rise post chemotherapy treatment

User
Posted 01 Jul 2025 at 18:28

My 83 year old husband’s latest PSA has risen from 0.4 to 2.6. Over the last two years his result was around 0.2 yo 0.4. He is worried especially as he was sent appointments for a bone and CT scans. He plays tennis twice a week and badminton once a week. He has no pain in any part of his body. Is it normal to have these scans post two years chemotherapy and radiotherapy treatment for advanced prostate cancer?  

User
Posted 01 Jul 2025 at 23:21

Hi Maud, it is a while since we heard from you, and on this forum that is a good thing.

His initial diagnosis of metastatic cancer, meant it would not be curable. The chemo has kept it at bay for a few years, and I presume he can have further rounds of chemo which will hopefully keep it at bay for some time longer.

It is unusual to have further scans after an initial metastatic diagnosis, as usually the treatment is systematic rather than targeted at a specific area, so they don't need to know where the cancer is. It is good news that they are doing these scans as it implies they think they can treat a targeted area presumably with radiotherapy.

His level of fitness will definitely help him deal with the side effects of treatment. Is he on hormone therapy at the moment?

Dave

User
Posted 02 Jul 2025 at 08:32

Hi Dave, thank you for your response. Mike was having his 6 monthly injection which will now be reduced to every 3 months. It’s interesting that you say it’s unusual for Mike to have further scans due to his diagnosis of advanced metastatic cancer. I am hoping as you say it’s a positive move even though his last PSA of 2.6 is within the normal range.  Yes, Mike remains very active and do far has not experienced any pain in his bones🤞. Ironically he said he feels really well and this is why he is anxious about the scans etc. Maud. 

User
Posted 02 Jul 2025 at 20:35

It's very good that your husband feels well and is keeping active:  quality of life is the most important thing!

If you look at my profile you'll see I had further scans 3 to 4 years after my initial diagnosis, it's a good thing as it will enable the team to see what might be driving the increase in PSA and give a targeted response, as Dave pointed out.

I wouldn't be worried at this point, I think it's a positive move by your husband's oncology team.  Just see what the scans show and what the team's decision is.  Wishing you both all the very best.

User
Posted 04 Jul 2025 at 12:14

HI Craig, having read your cancer journey I feel truly inspired by your positive attitude to life. You are so right in saying that quality of life is so important. Take good care of yourself.  Maud. 

 
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