Hi again MrsW. 👋
There have been several conversations on PNI. On one:
https://community.prostatecanceruk.org/posts/t31633-Suspicion-of-Perineural-Invasion
Andy62, summed it up very well.
"Perineural Invasion means the cancer was found to be tracking along inside nerve sheaths inside the prostate. That slightly increases the chance that it could have tracked outside the prostate via nerves from the prostate bed, but this is only a very slight increase in risk, and some oncologists suggest none at all. If you are weighing up treatments, it's a very minor factor in favour of external beam radiotherapy, as that will spill into the prostate bed too hopefully mopping up any spread into it, but again not a big factor because the extra risk is small. It's also a small factor against Active Surveillance, because it's a slightly higher risk than if it wasn't there, hence why they have caveted the Active Surveillance with this warning.
These are not the erection nerves, and it doesn't say anything about the prospects of nerve sparing or not."
Hope this helps. 👍
Edited by member 06 Aug 2025 at 10:04
| Reason: Additional text