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After the biopsy, diagnosis in the biopsy report

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User
Posted 01 Oct 2025 at 06:09

Biopsy was performed one week ago, and I received the results yesterday.


It showed Gleason 4+3, on both sides, but most of the tumor was in the cores from the right side (funny thing is that on the mpMRI, the right side looked less worrisome).


According to the doctor, surgery will hopefully take place in early November.


Honestly, I wasn’t expecting cancer, let alone a 4+3… but it is what it is. I cried a bit, but I have to accept it. Let’s see what they find during surgery if eventually takes place.


One question: I know that after surgery they can reclassify the results for worse. Has anyone ever seen a case where the final results were actually better than those from the biopsy?

Edited by member 02 Oct 2025 at 19:56  | Reason: Not specified

User
Posted 01 Oct 2025 at 07:50

Hello, mate.


I'm sorry that your biopsy results weren't as good as you had hoped for.


As regards your query of whether Gleason scores can be downgraded. Research shows that after prostate surgery Gleason scores are often upgraded and downgraded. On average about 25-30% are upgraded, 10-15% are downgraded.


Best of luck with your operation. 👍


Please keep us updated.

Edited by member 01 Oct 2025 at 07:51  | Reason: Typo

User
Posted 01 Oct 2025 at 08:01

Sorry to hear of the shock. Did they classify it as 2.x or 3.x?


My Gleason was downgraded BTW. From 3 5 to 3 4


All the best Rob

User
Posted 01 Oct 2025 at 09:43

Hi Adrian, thanks. I've got my 6 monthly in a few weeks.


 


Saw all your results are good. Catch you soon.


Rob

User
Posted 01 Oct 2025 at 10:37

Hi Chema


My post-surgery pathology downgraded me from 4+4 to 4+3 and down-staged me from 3a to 2c. 


Hope the operation goes well


Best wishes


Kevin


 

User
Posted 02 Oct 2025 at 19:54

Originally Posted by: Online Community Member


Hello, mate.


I'm sorry that your biopsy results weren't as good as you had hoped for.


As regards your query of whether Gleason scores can be downgraded. Research shows that after prostate surgery Gleason scores are often upgraded and downgraded. On average about 25-30% are upgraded, 10-15% are downgraded.


Best of luck with your operation. 👍


Please keep us updated.



Thank you. I hope the surgery will take place (I need a PET and hope there are no surprises), and if the surgery takes place, I hope the results will not show a worse diagnosis.


I keep you posted.

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User
Posted 01 Oct 2025 at 07:50

Hello, mate.


I'm sorry that your biopsy results weren't as good as you had hoped for.


As regards your query of whether Gleason scores can be downgraded. Research shows that after prostate surgery Gleason scores are often upgraded and downgraded. On average about 25-30% are upgraded, 10-15% are downgraded.


Best of luck with your operation. 👍


Please keep us updated.

Edited by member 01 Oct 2025 at 07:51  | Reason: Typo

User
Posted 01 Oct 2025 at 08:01

Sorry to hear of the shock. Did they classify it as 2.x or 3.x?


My Gleason was downgraded BTW. From 3 5 to 3 4


All the best Rob

User
Posted 01 Oct 2025 at 09:27

Hi Rob, 


Great to hear from you again. 


By  2.x and 3.x.  Do you mean, if Chema's cancer is stage 2 and stage 3?


So,  your Gleason was downgraded 8 (3+5) to 7 (3+4). Mine went the other way, upgraded from 8 (3+5) to 9 (4+5)


I hope that your post op PSA results are still good.

Edited by member 01 Oct 2025 at 09:39  | Reason: Typo

User
Posted 01 Oct 2025 at 09:43

Hi Adrian, thanks. I've got my 6 monthly in a few weeks.


 


Saw all your results are good. Catch you soon.


Rob

User
Posted 01 Oct 2025 at 10:37

Hi Chema


My post-surgery pathology downgraded me from 4+4 to 4+3 and down-staged me from 3a to 2c. 


Hope the operation goes well


Best wishes


Kevin


 

User
Posted 01 Oct 2025 at 15:43

Thanks all for your answers.


Originally Posted by: Online Community Member


Sorry to hear of the shock. Did they classify it as 2.x or 3.x?


My Gleason was downgraded BTW. From 3 5 to 3 4


All the best Rob



I don't know the T classification. I only have the pathology report about positive cores.

User
Posted 02 Oct 2025 at 19:54

Originally Posted by: Online Community Member


Hello, mate.


I'm sorry that your biopsy results weren't as good as you had hoped for.


As regards your query of whether Gleason scores can be downgraded. Research shows that after prostate surgery Gleason scores are often upgraded and downgraded. On average about 25-30% are upgraded, 10-15% are downgraded.


Best of luck with your operation. 👍


Please keep us updated.



Thank you. I hope the surgery will take place (I need a PET and hope there are no surprises), and if the surgery takes place, I hope the results will not show a worse diagnosis.


I keep you posted.

 
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