I'm interested in conversations about and I want to talk about
Know exactly what you want?
Show search

Notification

Error

PSA stable but lesion progressing

User
Posted 11 Oct 2025 at 08:07

Hi All,

My history so far is:

Transperineal biopsy (24 core) found 23 clear and 1 core with 5% PCa (G4) in targeted suspicious area found on MRI scan. G4 well contained, wide margins, within prostrate. Result G3 + 4 = 7.  

Lesion appears to be growing at a rate of 1 mm per year based on 2 yearly MRI scans (last one a few weeks ago).

Still a wide margin from the edge of the capsule.

Currently on AS since being diagnosed in 2022 with 3 monthly PSA testing. (PSA is stable averaging around 6.20).

Prostate quite large at 71cc.

TRUS  in past has not found PCa within the Lesion area but did find a small amount elsewhere (G 3+4) from the 24 core samples.

Urology are requesting a further TRUS biopsy within the next few months.

My question is, if the forthcoming TRUS finds a significant amount of PCa within the lesion area then intervention will probably be needed but if the TRUS finds nothing within the lesion area where do I go from here ? 

It appears that AS might no longer be an option. 

I'm just trying to get prepared for what could be coming. 

Edited by member 11 Oct 2025 at 17:59  | Reason: Not specified

User
Posted 11 Oct 2025 at 09:17

Hello BRD,

Your PSA is relatively low. You've got an enlarged prostate and have had prostatitis, which could account for some of the elevated PSA level.

Your active surveillance monitoring appears to be very good. Unless your new biopsy finds disease progression, I can't see why you'd need further treatment.

Good luck, mate.👍

User
Posted 12 Oct 2025 at 12:16

Thanks Adrian.

I suppose I will have to wait and see what the next TRUS finds / doesn't find and take it from there.

The dilemma will be if the lesion is still progressing and no significant PCa is found by the TRUS. It will then be a case of what to believe : the MRI or TRUS.

 

 

 
Forum Jump  
©2025 Prostate Cancer UK