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PSA test range

User
Posted 25 Oct 2025 at 12:33

I posted on another forum that my PSA came back at less than 0.1 8 weeks after prostatectomy which surgeon and others are saying is great news as it is basically undetectable, on the flip side I have also been advised that to get a more accurate reading I would need a ultra sensitive  PSA test as the test I had done at the doctors doesn’t read lower than 0.1

I have seen many times discussions on here where people mention there PSA results are in the 0.01/2/3 etc range so my question is where do you get these tests that read to 0.0 level as from what I can see not many places offer this ultra sensitive test ?

Any thoughts appreciated

thanks

Nick

 

 

User
Posted 25 Oct 2025 at 16:27

In my view, everywhere which deals with prostatectomy patients should be measuring down to 0.03 at least, and 0.01 would be nice.

Anywhere which only has a resolution of 0.1 can't meet the requirement to identify 3 consecutive rises between 0.1 and 0.2, and also you ideally want to be no more than 0.03 after a prostatectomy. Some hospitals now are initiating salvage treatment on consecutive rises below 0.1, which are obviously not detectable if 0.1 is the lowest measured.

My treatment hospital only measured down to 0.1, so my consultant preferred me to get tested at my local hospital which went down to 0.01 at the time, but now only goes down to 0.03. In a review of my treatment hospital which was going on while I was being treated, they were told 0.1 wasn't good enough, and they now have to send PSA tests off to another hospital lab which can measure lower.

A minimum of 0.1 is generally fine for patients who still have a prostate (but not salvage radiotherapy patients who don't).

User
Posted 25 Oct 2025 at 21:09

I think most NHS hospitals go below 0.1, but there are certainly some which don't.

The charity testing done by Graham Fulford (and all the charities which use him such as support groups, Lions, etc) test down to 0.01, so that might be another way to get a more sensitive test, but please pay the full cost (around £29) and don't let these organisations subsidise you, as the funds they raise to subsidise this testing are for testing men who haven't been tested or diagnosed with prostate cancer, in the hope of licking up more cancers early, which is not relevant to you.

You should get tests done by the same labs each time. Using different labs for comparative values particularly at low levels will give misleading results.

User
Posted 25 Oct 2025 at 21:16
I don't think the fact the lowest measurement they report is 0.1 means their resolution is 0.1. I think it means they think there is too much "noise" in their measurements to allow interpretation of values less than 0.1.

Certainly my hospital used a figure of 0.05 as their lowest measurable level, but once my PSA rose from <0.05 to 0.05 I was given measurements to the second decimal place. Their criterion for salvage RT was PSA rising above 0.2, so it was something that I saw coming bit by bit, although the consultant said he had known patients whose initial rise to a level under 0.2 then stabilised.

User
Posted 26 Oct 2025 at 12:50

Hi, my health authority also only measures to one decimal place which did worry me at first as I couldn't track any gradual rise after a prostatectomy. I looked for a private test locally but they all only gave results to one decimal place as well and it was suggested that they use the same labs as the hospital. My health authority won't take any further action ie PSMA PET scan etc until its reached 0.2 at a minimum anyway.  I'm meeting the consultant again next week so will ask the question again about more detailed testing.

User
Posted 26 Oct 2025 at 17:20

Nick , it may be worth contacting a Genisis Care centre, they may require a referral from a doctor. My hospital used to test down to 0.03 a couple of years ago the bought a new machine that tests down to O.025. Following my surgery my PSA was 0.03, having that extra detail meant I knew that my PSA was creeping up. Had my hospital only tested to 0.1 at two years post op I would suddenly have been told, " we have a problem". 

Thanks Chris 

User
Posted 27 Oct 2025 at 07:27

We had a discussion about this a couple of months ago at our support group when one of the nurses was present. The hospital measures down to 0.001 etc. There is another local hospital which only gives results as <0.1. There are a number of guys understandably who fret if their PSA goes from <0.001 to say 0.002 or 0.003. As the nurse said that is minuscule and can be due to natural fluctuations. The other hospital by reporting at <0.1 avoids that anxiety. But does it then come as a surprise if all of a sudden it pops above 0.1 as there is no way of measuring increases? The conclusion was there’s no right or wrong way as everyone reacts differently. My view is I prefer the more accurate readings as it may show a trend but don’t hung up about it. In my case so far so good as other than a small variation  my psa has stayed <0.001. 

User
Posted 27 Oct 2025 at 09:52

Ask for a copy of the blood report mate. the surgery receive this from the lab. My GP was reporting mine as being <0.01. when the actual number was <0.006. my lab happened to use one of the most sensitive tests available but I saw the logic in my GP‘s reporting method because this reading at this ultra level of sensitivity could kick about a bit 0.007/0.008 (which made me anxious) then normally stabilise back to <0.006. they’ve since changed to using the Abbott method I think which reports down to <0.035. I’m happy with that to be honest as I don’t need to see noise in data which can be caused by all sorts of things like machine calibration or just microscopic amounts of PSA that are naturally in the body emitted from other glands.

I wouldn’t be too concerned but additional visibility is always useful to a point.

User
Posted 27 Oct 2025 at 11:57

Confusion surrounding PSA test results occurs because consultants don't really explain some simple facts: Generally any PSA above 0.1 or 0.2 (depending on the consultant) means that treatment is necessary. It is important to measure your PSA at the same laboratory so that you can follow the trend - so long as it remains stable and below the critical level (0.1/0.2) all is well, as far as anyone can tell. Anyone who tells you that your PSA is 0.0 is scientifically incorrect. The accuracy depends entirely on the instruments used; you can't measure 0.0 PSA. 

For the first 5 years after my prostatectomy my PSA was <0.003 (measure my my 'private' hospital). However after we moved my GP's measured value came out at 0.06 (without the < sign). So I went back to the consultant, he ordered another test which came out at <0.003!

Changing laboratories only confuses the issue.

 'Physics is like sex: sure, it may give some practical results, but that’s not why we do it.'                    Richard Feynman (1918-1988) Nobel Prize laureate

 

 

User
Posted 27 Oct 2025 at 12:13

My GP forgot the < a couple of times. Processes have been updated ðŸĪŠðŸ‘€ One reason I usually request a copy of my blood report ‘for my private consultant’ 😛

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User
Posted 25 Oct 2025 at 16:27

In my view, everywhere which deals with prostatectomy patients should be measuring down to 0.03 at least, and 0.01 would be nice.

Anywhere which only has a resolution of 0.1 can't meet the requirement to identify 3 consecutive rises between 0.1 and 0.2, and also you ideally want to be no more than 0.03 after a prostatectomy. Some hospitals now are initiating salvage treatment on consecutive rises below 0.1, which are obviously not detectable if 0.1 is the lowest measured.

My treatment hospital only measured down to 0.1, so my consultant preferred me to get tested at my local hospital which went down to 0.01 at the time, but now only goes down to 0.03. In a review of my treatment hospital which was going on while I was being treated, they were told 0.1 wasn't good enough, and they now have to send PSA tests off to another hospital lab which can measure lower.

A minimum of 0.1 is generally fine for patients who still have a prostate (but not salvage radiotherapy patients who don't).

User
Posted 25 Oct 2025 at 17:56

This is what surprised me and the doctors didn’t even understand what I was trying to ask them, they had never heard of ultra sensitive PSA testing, I am presuming then that only hospitals or maybe private can do this test, the amount of people I see who mention the much lower scales must be getting it done ok 

thanks for the reply mate

Nick

User
Posted 25 Oct 2025 at 21:09

I think most NHS hospitals go below 0.1, but there are certainly some which don't.

The charity testing done by Graham Fulford (and all the charities which use him such as support groups, Lions, etc) test down to 0.01, so that might be another way to get a more sensitive test, but please pay the full cost (around £29) and don't let these organisations subsidise you, as the funds they raise to subsidise this testing are for testing men who haven't been tested or diagnosed with prostate cancer, in the hope of licking up more cancers early, which is not relevant to you.

You should get tests done by the same labs each time. Using different labs for comparative values particularly at low levels will give misleading results.

User
Posted 25 Oct 2025 at 21:16
I don't think the fact the lowest measurement they report is 0.1 means their resolution is 0.1. I think it means they think there is too much "noise" in their measurements to allow interpretation of values less than 0.1.

Certainly my hospital used a figure of 0.05 as their lowest measurable level, but once my PSA rose from <0.05 to 0.05 I was given measurements to the second decimal place. Their criterion for salvage RT was PSA rising above 0.2, so it was something that I saw coming bit by bit, although the consultant said he had known patients whose initial rise to a level under 0.2 then stabilised.

User
Posted 26 Oct 2025 at 12:50

Hi, my health authority also only measures to one decimal place which did worry me at first as I couldn't track any gradual rise after a prostatectomy. I looked for a private test locally but they all only gave results to one decimal place as well and it was suggested that they use the same labs as the hospital. My health authority won't take any further action ie PSMA PET scan etc until its reached 0.2 at a minimum anyway.  I'm meeting the consultant again next week so will ask the question again about more detailed testing.

User
Posted 26 Oct 2025 at 17:20

Nick , it may be worth contacting a Genisis Care centre, they may require a referral from a doctor. My hospital used to test down to 0.03 a couple of years ago the bought a new machine that tests down to O.025. Following my surgery my PSA was 0.03, having that extra detail meant I knew that my PSA was creeping up. Had my hospital only tested to 0.1 at two years post op I would suddenly have been told, " we have a problem". 

Thanks Chris 

User
Posted 27 Oct 2025 at 07:27

We had a discussion about this a couple of months ago at our support group when one of the nurses was present. The hospital measures down to 0.001 etc. There is another local hospital which only gives results as <0.1. There are a number of guys understandably who fret if their PSA goes from <0.001 to say 0.002 or 0.003. As the nurse said that is minuscule and can be due to natural fluctuations. The other hospital by reporting at <0.1 avoids that anxiety. But does it then come as a surprise if all of a sudden it pops above 0.1 as there is no way of measuring increases? The conclusion was there’s no right or wrong way as everyone reacts differently. My view is I prefer the more accurate readings as it may show a trend but don’t hung up about it. In my case so far so good as other than a small variation  my psa has stayed <0.001. 

User
Posted 27 Oct 2025 at 09:52

Ask for a copy of the blood report mate. the surgery receive this from the lab. My GP was reporting mine as being <0.01. when the actual number was <0.006. my lab happened to use one of the most sensitive tests available but I saw the logic in my GP‘s reporting method because this reading at this ultra level of sensitivity could kick about a bit 0.007/0.008 (which made me anxious) then normally stabilise back to <0.006. they’ve since changed to using the Abbott method I think which reports down to <0.035. I’m happy with that to be honest as I don’t need to see noise in data which can be caused by all sorts of things like machine calibration or just microscopic amounts of PSA that are naturally in the body emitted from other glands.

I wouldn’t be too concerned but additional visibility is always useful to a point.

User
Posted 27 Oct 2025 at 11:05

Thanks Chris and yes will look into it, funny enough I used Genesis in Oxford for. MPMRI scan 

User
Posted 27 Oct 2025 at 11:57

Confusion surrounding PSA test results occurs because consultants don't really explain some simple facts: Generally any PSA above 0.1 or 0.2 (depending on the consultant) means that treatment is necessary. It is important to measure your PSA at the same laboratory so that you can follow the trend - so long as it remains stable and below the critical level (0.1/0.2) all is well, as far as anyone can tell. Anyone who tells you that your PSA is 0.0 is scientifically incorrect. The accuracy depends entirely on the instruments used; you can't measure 0.0 PSA. 

For the first 5 years after my prostatectomy my PSA was <0.003 (measure my my 'private' hospital). However after we moved my GP's measured value came out at 0.06 (without the < sign). So I went back to the consultant, he ordered another test which came out at <0.003!

Changing laboratories only confuses the issue.

 'Physics is like sex: sure, it may give some practical results, but that’s not why we do it.'                    Richard Feynman (1918-1988) Nobel Prize laureate

 

 

User
Posted 27 Oct 2025 at 12:13

My GP forgot the < a couple of times. Processes have been updated ðŸĪŠðŸ‘€ One reason I usually request a copy of my blood report ‘for my private consultant’ 😛

 
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