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Blood in semen plus alarming PI-RADS score

User
Posted 10 Dec 2025 at 14:47

Hello, first post on the site. I'm white, mid 50s, in (what I thought) was good health - am not overweight, eat healthy food etc.

However...for five years I have been experiencing blood in my semen. I have had numerous digital examinations and blood tests - have been told my prostate feels normal (smooth) - plus my PSA score has been very low (under 2 each time, have had three blood tests, most recent this year). However the symptoms have continued and I pushed for an MRI. This has come back with the great news that I've got a lesion in my prostate and that my PI RADS score is 4. I appreciate 4 isn't as grim as getting a 5 but it's not overly reassuring either.

I'm seeing a consultant next week.

My first question would be, does a PI RADS score of 4 mean I'll definitely be offered a biopsy? As far as I'm aware that (score of 4) puts me at significant risk.

Also if anyone has any advice of what sort of questions I should be asking, issues I can raise, and what I can reasonably expect? I appreciate that they can't tell me a lot until a biopsy has happened.

Any advice appreciated - thanks v much.

 

 

Edited by member 10 Dec 2025 at 15:09  | Reason: typo

User
Posted 11 Dec 2025 at 11:02

Hi, Kralin.

I'm sorry that you're having possible prostate problems, but welcome to the forum, mate. 

The blood in your semen could be an indication of PCa, but it is far more likely to be caused by something else.

Your PSA is low, yet the Pi-rads 4 indicates a high chance of PCa. There have been many cases of Pi-rads 4 scans turning out to be caused by inflammation or other benign prostate conditions. On the other hand, there are cases of having low/ normal PSA not detecting PCa, false negatives.

I dont know if they'll deem your scan results worthy of a biopsy. If I were you I'd probably ask for one just to put my mind at rest.

Good luck, mate.👍

User
Posted 12 Dec 2025 at 10:05
Thanks for getting back, and for the welcome.

Yes I will ask. Another factor is that one of my parents passed away from pancreatic cancer, and I believe that the boffins think there is some correlation between that and prostate cancer.

Plus my MRI has classified that there's a tumour there.

User
Posted 12 Dec 2025 at 12:26

Hi,

My psa was borderline to prompt and mri scan. That identified two lesions scored at 4.

That triggered a biopsy which came back with no trace of cancer in the samples taken. There was zero explanation of anything after the biopsy which left me feeling pretty unsure. I had to push to get repeat psa tests to monitor what's going on. 

I had no symptoms except night time urgency so the whole thing was a shock to me. 

I was 59 when it started and a year on I still feel that I have no clue as the what was happening with my prostate and if things are bound to get worse in time.

My older brother has just been diagnosed with terminal PCa and bone mets, so I'm not at all confident the NHS is as proactive as it claims to be.

I hope you get a biopsy (for me not a difficult or painful procedure) and find out what is going on down there. 

Best regards Mick 

User
Posted 12 Dec 2025 at 13:40

Thanks for getting in touch Mick. I am sorry about your brother.

Your situation sounds unsettling, to say the least, like you're in some sort of NHS grey area. Given the situation with your brother hopefully they will (at the very least) repeat the PSA testing, not just annually either. I've no idea if it's possible to get them repeated every six months.

I should have added above that I've had a few digital examinations and all have said the prostate is smooth. But obviously a digital examination cannot see what's inside.

My experience with the NHS has been ok - I've clearly been very low priority given the PSAs and digital checks - but up until the MRI they've been fairly non-plussed, and in reassurance mode and were even asking things like whether I'd indulged in risky sex, etc.

I will be pushing very hard for a biopsy. Thanks for the reassurance re the pain of it all, it seems a grit your teeth and lie back and think of something pleasant situation.

Edited by member 12 Dec 2025 at 13:41  | Reason: typo

User
Posted 13 Dec 2025 at 07:56

I had a transrectal biopsy, where the samples are taken inside. There's a higher risk of infection but they give you a dose of antibiotics before hand to try and lessen that risk.

It really wasn't painful and only mildly embarrassing, but its a medical procedure after all. 

The transperineal version still has an ultra sound probe inside but the needles go in from outside. 

Whichever you have you will still get blood in your pee and semen, which can look quite scary till it clears, but you already know that.

They didn't do any form of DRE on me before the MRI scan as they said it was pretty unreliable and more or less redundant as a diagnostic tool. 

I hope you get a biopsy, you do have to push and advocate for these things. I think there is a reluctance to carry out procedures that on paper seem unnecessary but that to the worried patient would mean a lot of reassurance. My brother was denied an MRI in the early stages as they said it wouldn't add to what they knew. 5 months later he is waiting fir an MRI as something is going on they didn't expect. Woukd it have been better to have done an MRI back when they really should have? I think so, but they would never admit to that. 

The NHS are good, but they are under pressure from government etc to keep costs down, so you do have to know what you want and press for it.

My own GP has set up psa testing for me every six months,  despite the hospital saying it should only be repeated if I had any further concerns about my prostate.  The thing is I didn't have any symptoms or concerns until the random psa test. I really got the impression I was thought of as being a time waster by the MDT as they were very dismissive when my results were clear. 

Let us know how things pan out. 

Mick 

 
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