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ADT - Sleep Issues

User
Posted 28 Dec 2025 at 10:25

I am one month into ADT (Relugolix / Orgovyx). I can cope with the hot flashes OK as the are short-lived, just a few minutes maybe. I have learned to dress in layers which helps quick removal of clothing if necessary. What is causing me the most annoyance however is insomnia.  

A bit of background first. I am a 61 year old Irish man. Gleason 8 (4+4). Staging T2. SpaceOAR and gold fiducials insertion in two weeks time. EBRT in 4 weeks tine. I am currently waking every hour during the night, it is not always with a need to urinate, but this is much more frequent than before starting ADT, it can be caused by a hot flash.

I often lie awake for two hours before getting back to sleep. I am obviously not getting any REM sleep and am exhausted during the day.

I have tried liquid magnesium glycinate and valerian drops for the past week. Slight improvement but only slight.

I have heard of melatonin tablets but these require a prescription in Ireland, I could travel to Northern Ireland where they are available over the counter I believe. I dont drink coffee or tea after 5pm. I dread to think what another 5 months of this will be like.

Has anyone else experienced this? Any suggestions? 

User
Posted 28 Dec 2025 at 17:58

Liam, I found I was struggling to sleep with apalutamide, I swapped from taking them at night too taking them in the morning. That did help a bit, now I get up in the morning ,go for a walk, come back and fall asleep. 

Thanks Chris 

User
Posted 29 Dec 2025 at 08:59

Thanks for that Chris. I am taking my Relugolix at lunchtime, so I don't think it is the timing. 

Liam

 
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