Receiving Lutetium 177 Treatment

User

Posted 31 Dec 2025 at 13:36

Hi All

I started Lutetium 177 Treatment back in September. Just thought I would post to try to help with an understanding.

I have received both Docetaxel and Cabazitaxel and neither brought any positive results. Please read my profile for more understanding on the progression.

Luckily I have private Health Insurance through my employer, so this made the treatment available.

14/08/2025 - PET Scan completed to understand if the body will accept the treatment.

18/08/2025 - PET scans positive so treatment to be arranged.

Six cycles to be administered every six weeks.

23/09/2025 - Cycle 1 - PSA 5.18, ALP 304

The treatment takes 2 hours to complete. The treatment is administered and then you receive a scan before leaving to ensure the treatment has been administered throughout the body.

Felt a little nausea during the first week after the treatment. A little off my appetite, by apart from that all was ok.

04/11/2025 - Cycle 2 - PSA 0.5, ALP 224

No side effects after cycle 2

16/12/2025 - Cycle 3 - PSA 0.43, ALP 216

Again no side effects after treatment, consultant encouraged by the results from bloods taken.

User

Posted 31 Dec 2025 at 13:36

Hi All

I started Lutetium 177 Treatment back in September. Just thought I would post to try to help with an understanding.

I have received both Docetaxel and Cabazitaxel and neither brought any positive results. Please read my profile for more understanding on the progression.

Luckily I have private Health Insurance through my employer, so this made the treatment available.

14/08/2025 - PET Scan completed to understand if the body will accept the treatment.

18/08/2025 - PET scans positive so treatment to be arranged.

Six cycles to be administered every six weeks.

23/09/2025 - Cycle 1 - PSA 5.18, ALP 304

The treatment takes 2 hours to complete. The treatment is administered and then you receive a scan before leaving to ensure the treatment has been administered throughout the body.

Felt a little nausea during the first week after the treatment. A little off my appetite, by apart from that all was ok.

04/11/2025 - Cycle 2 - PSA 0.5, ALP 224

No side effects after cycle 2

16/12/2025 - Cycle 3 - PSA 0.43, ALP 216

Again no side effects after treatment, consultant encouraged by the results from bloods taken.

User

Posted 01 Jan 2026 at 15:46

Hello Parkie

I have had 177Lu treatment ... two doses - first one 7.6 GBq, second one was 5,5 GBq - can you tell us how strong a dose you were given. Also do you have a PET scan to visualise what is going on. In my case I have been at psa <0.01 ng/ml for the last six months and the latest PET scan was clear. Do you have any signs of 'dry mouth'?

Keep us informed and good luck with this.

Crispin

Edited by member 01 Jan 2026 at 15:50 | Reason: Not specified

User

Posted 31 Mar 2026 at 20:22

Hi All

Just a quick update on the treatment.

23/09/2025 - Cycle 1 - PSA 5.18, ALP 304

Felt a little nausea during the first week after the treatment. A little off my appetite, by apart from that all was ok.

04/11/2025 - Cycle 2 - PSA 0.5, ALP 224

No side effects after cycle 2

16/12/2025 - Cycle 3 - PSA 0.43, ALP 216

No side effects after cycle 3

27/01/2026 - Cycle 4 - PSA 0.36, ALP192

No side effects after cycle 4

10/03/2026 - Cycle 5 - PSA 0.37, ALP 183

Felt a slight nausea on the first week, after cycle 5 but nothing too bad

The blood results seem to be positive. Although my White cell count was 2.33 and my Neutrophil 1.43 on the blood test previous to the last treatment.

Unlike chemotherapy this does low count does not stop the treatment.

I have felt ok throughout the treatment and luckily have not suffered from the low count and managed so far to stay away from any viruses.

I did ask the consultant on foreign travel and he was happy for me to travel, so hopefully we may get away at some point soon.

User

Posted 31 Mar 2026 at 21:02

Hello Neil

This looks all positive

You have one more cycle? Do you know the dosage of 177Lu that they administer each time (usually some number of GBq) .. You said originally that you will have a PSMA PET scan at the end ...

Good luck - Keep us informed please

best

Crispin

User

Posted 03 Apr 2026 at 09:21

Thanks for the update on what seems to be a new treatment plan for the men on this forum.

Good luck mate, keep fighting!

User

Posted 03 Apr 2026 at 10:27

Hi Parkie

Seems like you've coped well with treatment,hoping this has knocked the cancer back for the foreseeable future.

Keep us updated with your progress and wishing you all the best.

Phil

User

Posted 03 Apr 2026 at 12:47

Really glad to see the positive effects of the Lu-177 for you. I hope you very much enjoy some travel.

User

Posted 03 Apr 2026 at 15:55

Hello Niel

Just a quick note re travel - I live in France - but have 177Lu treatment in Germany - German law states that I have to stay in the clinic for two nights after treatment ... I am issued with a letter just in case I set off any radiation alarms. If I had treatment in Austria - I could arrive in the morning - get the 177Lu treatment and then fly off home in the afternoon.

There is a radiation monitor at my place of work - I triggered this for 4 weeks after my first dose of 177Lu .. shorter time after the 2nd dose. (I had to show the letter that stated I was not a danger to anyone)

Enjoy your travels!

best regards Crispin

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User

Posted 31 Dec 2025 at 13:51

Parkie, thanks for the update,info on the lesser used treatments is always useful. I was considered for lut177, but unfortunately a kidney issue meant it wasn't recommended.

Results and tolerance to it look good.Hope it continues to be if benefit going forward.

Thanks Chris

User

Posted 31 Dec 2025 at 16:50

Hi Parkie,

Thanks for posting this. Very helpful for many of us. So glad to see that the side effects are minimal and 10-fold drop in PSA. Hope the benefits continue, and especially that you can enjoy this holiday season.

User

Posted 01 Jan 2026 at 09:11

Yes i also thankyou for posting and please keep us updated.

Wishing you all the best 👍

User

Posted 01 Jan 2026 at 15:46

Hello Parkie

Keep us informed and good luck with this.

Crispin

Edited by member 01 Jan 2026 at 15:50 | Reason: Not specified

User

Posted 05 Jan 2026 at 17:42

Hi Chris, sorry to hear the kidney condition prevented you receiving this treatment.

Hi Crispin, I haven't been advised the dosage that I received. I will enquire on that on my next treatment. As with chemotherapy I assumed it was administered due to size and weight.

Sounds like you have responded well to the treatment, have you just received two cycles and paused?

I will not receive a final PET Scan until after the last (6th) cycle. The consultant is going by the blood results currently and how I feel overall.

I have not had any problems with dry mouth or ulcers.

My next treatment is 27th January, will keep you updated guys.

Cheers Neil

User

Posted 05 Jan 2026 at 18:01

Hello Neil

To answer your questions: I had a PET scan before each dose of 177Lu-PSMA to see what was going on. The treating Professor thought I would be back for a 3rd dose ... but since my psa has been < 0.01 ng/ml and a PSMA-PET scan in November was clear -therefore I have had no 3rd dose. However I have advised to contact the professor if my psa rises...

I am also taking enzalutamide - this may be responsible for the psa value going down - but this medication also makes the tumours more avid for PSMA (and this is just what is needed for 177Lu-PSMA treatment).

Anyway Good luck keep us informed.

Crispin

User

Posted 31 Mar 2026 at 20:22

Hi All

Just a quick update on the treatment.

23/09/2025 - Cycle 1 - PSA 5.18, ALP 304

Felt a little nausea during the first week after the treatment. A little off my appetite, by apart from that all was ok.

04/11/2025 - Cycle 2 - PSA 0.5, ALP 224

No side effects after cycle 2

16/12/2025 - Cycle 3 - PSA 0.43, ALP 216

No side effects after cycle 3

27/01/2026 - Cycle 4 - PSA 0.36, ALP192

No side effects after cycle 4

10/03/2026 - Cycle 5 - PSA 0.37, ALP 183

Felt a slight nausea on the first week, after cycle 5 but nothing too bad

The blood results seem to be positive. Although my White cell count was 2.33 and my Neutrophil 1.43 on the blood test previous to the last treatment.

Unlike chemotherapy this does low count does not stop the treatment.

I have felt ok throughout the treatment and luckily have not suffered from the low count and managed so far to stay away from any viruses.

I did ask the consultant on foreign travel and he was happy for me to travel, so hopefully we may get away at some point soon.

User

Posted 31 Mar 2026 at 21:02

Hello Neil

This looks all positive

You have one more cycle? Do you know the dosage of 177Lu that they administer each time (usually some number of GBq) .. You said originally that you will have a PSMA PET scan at the end ...

Good luck - Keep us informed please

best

Crispin

User

Posted 03 Apr 2026 at 09:21

Thanks for the update on what seems to be a new treatment plan for the men on this forum.

Good luck mate, keep fighting!

User

Posted 03 Apr 2026 at 10:27

Hi Parkie

Seems like you've coped well with treatment,hoping this has knocked the cancer back for the foreseeable future.

Keep us updated with your progress and wishing you all the best.

Phil

User

Posted 03 Apr 2026 at 12:47

Really glad to see the positive effects of the Lu-177 for you. I hope you very much enjoy some travel.

User

Posted 03 Apr 2026 at 15:55

Hello Niel

Enjoy your travels!

best regards Crispin

User

Posted 07 Apr 2026 at 09:48

Hi Crispin,

Thanks for the advice there. Thanks for the good wishes guys.

I hope this information helps.

Apologies Crispin, I did mean to ask the dosage level on my last treatment and got sidetracked on another subject. I do know it is a constant for every dose.

I am due in for my last treatment on the 21st April and will enquire.

No travel as yet as I have ended up with a busy April, also I am hoping my white blood cells and neutrophils will bounce back a bit on the blood test this month.

Cheers

Neil

User

Posted 13 Apr 2026 at 13:54

Hi Crispin

I receive 7.4GBq 177Lu PSMA per visit.

Six visits in total.

Cheers

Neil

User

Posted 13 Apr 2026 at 14:10

Dear Neil

7.4 GBq is close to the maximum that they use - so you have had a fairly heavy dose ... I guess that they are using your psa readings to understand what is going on - hopefully it will remain at this lowish value for some time to come.

best regards

Crispin

User

Posted 13 Apr 2026 at 16:13

Thank you for the advice Crispin.

Cheers

Neil

User

Posted 18 Aug 2026 at 08:41

Hi All

Here is an update on the Lutetium treatment now that the course of treatment has been completed.

23/09/2025 - Cycle 1 - PSA 5.18, ALP 304

Felt a little nausea during the first week after the treatment. A little off my appetite, by apart from that all was ok.

04/11/2025 - Cycle 2 - PSA 0.5, ALP 224

No side effects after cycle 2

16/12/2025 - Cycle 3 - PSA 0.43, ALP 216

No side effects after cycle 3

27/01/2026 - Cycle 4 - PSA 0.36, ALP192

No side effects after cycle 4

10/03/2026 - Cycle 5 - PSA 0.37, ALP 183

Felt a slight nausea on the first week, after cycle 5 but nothing too bad

21/04/2026 - Cycle 6 - PSA 0.47, ALP 153

No side effects after cycle 6

03/06/2026 PSMA Scan Before and after scan results, which were really positive. Unfortunately I cannot paste the images.

17/06/2026 - I visited Spire for a consultation with one of the consultants. The advice was to have further blood tests every two months to monitor the situation, with the possibility of receiving Radium-223 treatment if and when there are signs of change.

Further blood tests:

09/06/2026 - PSA 0.7 ALP 172

28/07/2026 - PSA 2.0 ALP 194

Back under NHS and CT and Bone Scan taken on 16/08/2026 - Nothing to report

Edited by member 18 Aug 2026 at 08:45 | Reason: Not specified

User

Posted 18 Aug 2026 at 09:44

Hello Niel

Thanks for all the info ...

Good luck with this treatment....

ciao Crispin

User

Posted 18 Aug 2026 at 10:31

Parkie, does the rise to 2.0 indicate that the treatment has not been successful. I recall my PSA shooting up after my last treatment to a cancerous lymph node and a PSMA scan.

Best wishes for the future.

Thanks Chris.

User

Posted 22 Aug 2026 at 10:13

Hi Chris

The treatment was successful suppressing the cancer, but the PSA is always going to start rising again I guess. It is not a cure.

User

Posted 22 Aug 2026 at 10:46

Hi Parkie

The positive thing was the ALP coming down that indicates that the bone metastases were being treated ... but the psa reached a nadir after 4 cycles. pity that you can not paste the PSMA images but I would guess that this showed big reduction ...

Further treatments using Lu-PSMA require the metastasis to be PSMA avid ... so these PSMA-PET scans are very important. Maybe the Radium-223 treatment is a better option?

Good luck with treatment.

ciao Crispin

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