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Advice about Castrate Resistance from an Old Timer

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User
Posted 14 Jan 2026 at 18:26

Bump

Edited by member 30 Mar 2026 at 16:59  | Reason: Not specified

User
Posted 15 Jan 2026 at 02:53

This does sound like the right moment for a PET scan and depending on the results, you could well be able to have some form of focal therapy. 

I get slightly nervous when I see older men being recommended for HT, with the suspicion that it might "last them out".

As Andy says, what's changed and could you give us some more details please?

Jules

User
Posted 15 Jan 2026 at 14:01
Single lymph nodes? If so that could be treated again with RT if it's outside the previous treatment area...
User
Posted 15 Jan 2026 at 19:05

From what you've said it does look as though you could be a candidate for further treatment and as you said earlier in this thread, it's quite possible to become castrate resistant after a period of time. For you, at age 70, your life expectancy could well be beyond the period of time for which HT would keep working.

Take a look at Old Barry's profile here. He's now well into his eighties and has been relentless in searching out successful follow up treatment for recurrence after having had early radiotherapy. 

Jules

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User
Posted 14 Jan 2026 at 18:47

You have already bust the 2 to 3 years by a long margin as you have had several HT sessions in the past.

Time to castrate varies from weeks to never however so you might be lucky and never go castrate resistance.

I would be pushing for a PET scan to see where the cancer is.

Edited by member 14 Jan 2026 at 18:49  | Reason: Not specified

User
Posted 14 Jan 2026 at 19:44

 

It's true I have had some intermittent HT over the years which only makes me wonder if that will reduce my time when I go full time! 😁

Do my PC cells run a taxi meter on me?

I've had a recent PET Scan which led to my change to full time HT

Only wondering about rules of thumb and peoples experiences on this

Edited by member 14 Jan 2026 at 19:49  | Reason: Terrible spelling!

User
Posted 14 Jan 2026 at 20:27

I looked in your profile, but I can't work out a timeline with PSA levels and starting/stopping HT.

What's changed which makes your oncologist want you on permanent hormone therapy?

User
Posted 15 Jan 2026 at 02:53

This does sound like the right moment for a PET scan and depending on the results, you could well be able to have some form of focal therapy. 

I get slightly nervous when I see older men being recommended for HT, with the suspicion that it might "last them out".

As Andy says, what's changed and could you give us some more details please?

Jules

User
Posted 15 Jan 2026 at 10:51

Thanks all for your replies!

I had a PET 2 weeks ago after rise in PSA to 1.4 the scan showed cancer in a single lymph node.

The Oncologist believes my "Hormone Holiday" is over hence he intends to put me on HT permanently hence my question about what's everyone's experience and thoughts of how long HT lasts before castrate resistance? 

However I realise my Profile is confusing so I'll re-jig it and come back online in a while with the question.

Thanks again all!

User
Posted 15 Jan 2026 at 14:01
Single lymph nodes? If so that could be treated again with RT if it's outside the previous treatment area...
User
Posted 15 Jan 2026 at 19:05

From what you've said it does look as though you could be a candidate for further treatment and as you said earlier in this thread, it's quite possible to become castrate resistant after a period of time. For you, at age 70, your life expectancy could well be beyond the period of time for which HT would keep working.

Take a look at Old Barry's profile here. He's now well into his eighties and has been relentless in searching out successful follow up treatment for recurrence after having had early radiotherapy. 

Jules

 
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