Notification

Error

Hubby Starting Darolutamide

User
Posted 19 Jan 2026 at 09:02

Re Previous post we thought it would be Enzalutamide but now seen consultant medical oncologist and Darolutamide seems to be the best option.

Hubby Starting them today

Anyone have any experience or advice with taking Darolutamide. 

Always find personal experience very helpful.

Thanks again everyone 

User
Posted 19 Jan 2026 at 13:54

Hello, my 68 year old stage 4 T3bN1M1 husband has been on Decapeptyl and Darolutamide for the last 6 months after his initial diagnosis. He has had no noticeable side effects other than losing most of his post-puberty body hair. The loss of his bushy ear hair has made him very happy! He feels a bit weaker and more tired but nothing that really that interferes with his QoL. He hasn't had any hot flushes etc and he has his first bone density scan tomorrow. As is often stated, each person is different so hopefully your husband will have an equally non-evenful Darolutamide journey.

User
Posted 23 Jan 2026 at 21:27

Hello Julie,

I'm on triplet therapy and have been on Prostap and Darolutamide since mid 2024 (also had chemo at the time). I've not experienced any significant side effects at all - only the occasional hot flush and a little more tired generally but nothing significant. Best news is my PSA remains undetectable.

Show Most Thanked Posts
User
Posted 19 Jan 2026 at 13:54

Hello, my 68 year old stage 4 T3bN1M1 husband has been on Decapeptyl and Darolutamide for the last 6 months after his initial diagnosis. He has had no noticeable side effects other than losing most of his post-puberty body hair. The loss of his bushy ear hair has made him very happy! He feels a bit weaker and more tired but nothing that really that interferes with his QoL. He hasn't had any hot flushes etc and he has his first bone density scan tomorrow. As is often stated, each person is different so hopefully your husband will have an equally non-evenful Darolutamide journey.

User
Posted 23 Jan 2026 at 21:27

Hello Julie,

I'm on triplet therapy and have been on Prostap and Darolutamide since mid 2024 (also had chemo at the time). I've not experienced any significant side effects at all - only the occasional hot flush and a little more tired generally but nothing significant. Best news is my PSA remains undetectable.

User
Posted 23 Jan 2026 at 21:35
Thank you so much

Great news re your PSA.

User
Posted 25 May 2026 at 17:03

Things seem to be going ok with Darolutamide. PSA coming down 🤞it will be undectable soon. 

Hubby was very tired at first but settling now.

Hb has dropped and gets a bit short of breath.

Life goes on and we keep busy. 

Edited by member 25 May 2026 at 17:03  | Reason: Not specified

User
Posted 25 May 2026 at 18:05

Hi

I have ben on darolutamide since the beginning of February, having already started on Zoladex implants - so two HTs...Also had chemo, just finished 3 days ago!!

Difficult to put a finger on what has caused what but in terms of HT I have stopped growing a beard (almost) and am hanging on to my moustache - which I have had since I was about 16.  I am certainly putting weight on but that I am sure is the steroids that go along with the chemo. What little hair I had has now gone due to chemo - but not an issue.

Emotionally I have found a big change - I can get quite upset about stuff especially if it is sad news.  I have had wobbles when awake in the middle of the night - and wondered what on earth I am doing to myself.  I try not to get too upset in company but do occasionally let myself go when alone.

Manboobs are a real thing!  I exercise (weights/resistance bands) to make sure that I have chest muscle to compensate.

I do get hot flushes but these wax and wane, and can be so dependant on where I am in the treatment phase, whether I have had hot food/drink ... I just let them wash over and then get on with stuff.  At night I have a handy fan by the bed which is USB rechargeable (John Lewis I think) and this does help.  Bed coverings are on and off, and I sometimes potter off to the spare room to prevent my other half from getting disturbed.

Killing off the testosterone has its effects  - which are well documented -and these have impacted me.

BUT - life goes on, the weather is great and I can get to see the grandkids soon and have a break.

Plenty of exercise and healthy eating fights the fatigue, and I do not drink alcohol or have caffeine. Keeping well hydrated is the key  - try and stick to the recommended 2litres per day (but stop early enough in the evening to minimise trips in the night).

CeePee

 

Best wishes - stay positive

CeePee

User
Posted 25 May 2026 at 18:20

It is a battle at times & you are right keeping active it is the best thing to do.

My hubby is on antidepressants and these really help him with depression it is a known side effect of the hormone treatment,  but also normal to have a wobble. 

Don't be shy in mentioning depression and getting treatment the difference of being on antidepressants in my husband is like living with a different person,  he used to get very quiet and reflective and I wondered what I had done wrong. 

Grandkids are great aren't they ❤️

Thank you for your honest open reply wishing you all the best with your treatment. 

 

 
Forum Jump  
©2026 Prostate Cancer UK