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User
Posted 23 Jan 2026 at 17:18

Hi. First diagnosed about 13 years ago. Went on the Stampede trial and had radiotherapy. Been on Prostap 3 monthly injections since then. PSA  very low until about 18 months ago when started to rise to 5 , 10 and 15 over a year. Was on bicalutamide but bone scan 2 weeks ago shows further progression of the cancer. Consultant now suggest switching to Enzalutamide.  Waiting for approval and to start. I’m aware of the possible side effects but don’t have much choice. So wish me luck 

I’m 81 years old and lost my wife 6 years ago in March to breast cancer. Not sure if my family are aware that I was diagnosed that long ago. I haven’t told them that my PSA has increased and to go on stronger medication. But need to find the right time to let them know. 

I know not a terminal diagnosis and I’m aware some men have been on enzalutamide for a number of years with good results. 

User
Posted 23 Jan 2026 at 17:18

Hi. First diagnosed about 13 years ago. Went on the Stampede trial and had radiotherapy. Been on Prostap 3 monthly injections since then. PSA  very low until about 18 months ago when started to rise to 5 , 10 and 15 over a year. Was on bicalutamide but bone scan 2 weeks ago shows further progression of the cancer. Consultant now suggest switching to Enzalutamide.  Waiting for approval and to start. I’m aware of the possible side effects but don’t have much choice. So wish me luck 

I’m 81 years old and lost my wife 6 years ago in March to breast cancer. Not sure if my family are aware that I was diagnosed that long ago. I haven’t told them that my PSA has increased and to go on stronger medication. But need to find the right time to let them know. 

I know not a terminal diagnosis and I’m aware some men have been on enzalutamide for a number of years with good results. 

User
Posted 23 Jan 2026 at 22:30
Hi Alan,

Loads of fellas here have done and are doing very well on enzalutimide. I hope it's the same story for you.

My husband, Allan, had Abiraterone, the alternative to enzalutimide, but with abiraterone you have to take a steroid as well so I think enzalutimide seems better in terms of side effects. Am sure one of our lovely fellas on enzalutimide will be posting on your thread soon.

Sorry to hear your wife passed a few years ago, my Allan died just over a year ago so I can understand.

Also please know there are several treatments still left for you and more coming along all the time.

Good luck x

Mrs MAS

User
Posted 24 Jan 2026 at 11:17

Hi 

I got 18 months out of Enzalutamide with very little side affects some guys get years some guys get months everybody has different journeys i wish you well on yours.

Regards Phil 

User
Posted 24 Jan 2026 at 20:00

I've been on Enzalutamide for 3+ years. So far it's doing the job for me.  Main long term side effects are fatigue, loss of sex drive and ringing in ears. There were more to begin with but they wore off over time.  As Phil says, everyone's different so wishing you all the best with your treatment.

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User
Posted 23 Jan 2026 at 19:38

Hi, Alan.

Thanks for posting, mate.

I'm very sorry to hear about your wife's passing.

I'm afraid I know nothing about Enzalutamide, but there are blokes on here on it, and I'm sure they'll help you.

Good luck.👍

User
Posted 23 Jan 2026 at 22:30
Hi Alan,

Loads of fellas here have done and are doing very well on enzalutimide. I hope it's the same story for you.

My husband, Allan, had Abiraterone, the alternative to enzalutimide, but with abiraterone you have to take a steroid as well so I think enzalutimide seems better in terms of side effects. Am sure one of our lovely fellas on enzalutimide will be posting on your thread soon.

Sorry to hear your wife passed a few years ago, my Allan died just over a year ago so I can understand.

Also please know there are several treatments still left for you and more coming along all the time.

Good luck x

Mrs MAS

User
Posted 23 Jan 2026 at 22:37

Thanks for your message. Sorry for your loss. 

User
Posted 24 Jan 2026 at 11:17

Hi 

I got 18 months out of Enzalutamide with very little side affects some guys get years some guys get months everybody has different journeys i wish you well on yours.

Regards Phil 

User
Posted 24 Jan 2026 at 12:02

Phil

Thanks for your reply. I’ll have to wait and see how it goes. 

cheers 

Alan 

User
Posted 24 Jan 2026 at 20:00

I've been on Enzalutamide for 3+ years. So far it's doing the job for me.  Main long term side effects are fatigue, loss of sex drive and ringing in ears. There were more to begin with but they wore off over time.  As Phil says, everyone's different so wishing you all the best with your treatment.

User
Posted 24 Jan 2026 at 21:30

Thanks for the information. Good to hear you’re still taking it after 3 years. I’m told fatigue is one of the main side effects. I already have tinnitus in my years. Sex drive was gone years ago with the Prostap injections. Appreciate you responding. 

User
Posted 18 Mar 2026 at 22:14
Hi ,Ive been on ADT and Enzalutimide for 6 years now and my PSA has been undetectable all that time,, within one month of starting the medication my PSA was <0.01 .Everyone is different my cancer was very hormone sensitive and I am an ultra super responder to Enzalutimide.Thete are side effects but i manage them ok .

.

User
Posted 18 Mar 2026 at 22:46

Many thanks for your message. Only 6 weeks on enzalutamide so hope I go 6 years like yourself. Some side effects at the moment and think I’m managing them at the moment. Thanks again. Stay well 

User
Posted 20 Mar 2026 at 10:43

Originally Posted by: Online Community Member
Hi ,Ive been on ADT and Enzalutimide for 6 years now and my PSA has been undetectable all that time,, within one month of starting the medication my PSA was <0.01 .Everyone is different my cancer was very hormone sensitive and I am an ultra super responder to Enzalutimide.Thete are side effects but i manage them ok .
.

 

Is ultra super responder an industry term mate? I hope so, as I hope to achieve that with enzalutamide!

 
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