Male, 64 years old.
DaVinci Radical Prostatectomy in 2021, October.
No radiation done after radical prostatectomy.
Recovery after radical prostatectomy has been relatively smooth.
PSA has progressed ever since.
Date PSA ng/mL
24.11.2021 0.009
17.03.2022 0.027
31.05.2022 0.032
02.10.2022 0.038
13.02.2023 0.046
26.05.2023 0.056
02.11.2023 0.06
29.06.2024 0.09
13.03.2025 0.144
14.08.2025 0.206
Whole-body and pelvis 68 Ga-PSMA-11 PET/MR Performed: 2025-09-23" shows no detections.
19.10.2025 0.214
16.01.2026 0.226
What is best course of action now?
Cyberknife SBRT cannot be performed if no spots found.
Was offered IMRT radiation.
Questions:
1) In this case, what makes more sense, to do IMRT or wait and do repeated PSMA-PET to detect spots?
2) If one were to do IMRT, then what to pay attention to? How modern is device, centers of excellence in Europe, etc?
3) What are side effects of doing IMRT now? What problems could arise?
4) ADT or not?
5) Whom else to consult with regarding this?
Any other input would be much appreciated.
Anyone with similar experience, please share your story.
________________________ 59M, Gleason 4+3, PSA7.8, T2C. DaVinci Surgery in 2021. PSA rising after surgery. What to do next? |
User
User
Hi , some similar stats to my own. I was refused a PSMA scan, but that was back in 2017. So I had the educated guess salvage RT. I started my SRT at just over 0.2, there was something in the prostate bed because the PSA went down. There was also something outside the prostate bed because the PSA didn't go down as much as expected and soon started to rise again.
Years later following more PSA rises, PSMA scans showed activity in a pelvic lymph node,but didn't show any thing in the prostate bed.
Salvage RT did do some damage to my bladder but my level of damage is rare and there were numerous excursions into my bladder for other reasons.
If you wait for the PSA to rise it means the cancer is growing. You may not have any cancer in the prostate bed. I had SABR treatment to two separate pelvic lymph nodes on two separate occasions. Further scans showed extensive spread and I started HT last year.
Thanks Chris
User
I was automatically referred to an Oncologist when my PSA reached 0.2, 9 months after my RARP. He immediately put me onto hormone treatment and 20 fractions of radiotherapy. PSA is back to less than 0.1 but won’t know how successful everything has been until I stop the hormone treatment.
My Oncologist told me that any problem cells would be too small to show up on a PET scan but that the treatment path should be successful.
User
I had my RALP in November 2021. After 2 years my PSA rose to 0.2. My onco said that a PSMA scan may not show any spread at that level and so, starting September 2024, I had 33 sessions of EBRT to my prostate bed and pelvic lymph nodes followed by 12 month HT ( Decapeptyl). A broad brush approach to the most likely places. My first very recent PSA test came out as undetectable but whilst that is a great result, I realise it is too early to be sure of success.
Peter
User
Did EBRT come with any sides?
Originally Posted by: Online Community MemberI had my RALP in November 2021. After 2 years my PSA rose to 0.2. My onco said that a PSMA scan may not show any spread at that level and so, starting September 2024, I had 33 sessions of EBRT to my prostate bed and pelvic lymph nodes followed by 12 month HT ( Decapeptyl). A broad brush approach to the most likely places. My first very recent PSA test came out as undetectable but whilst that is a great result, I realise it is too early to be sure of success.
Peter
________________________ 59M, Gleason 4+3, PSA7.8, T2C. DaVinci Surgery in 2021. PSA rising after surgery. What to do next? |
User
Yes. For me, fatigue set in after a couple of weeks. Also, prior to EBRT I was continent to the extent that I didn't need to wear a pad when at home. Now, I wear one all the time. Just Tena level zero mostly, or level 1 if I am doing heavy physical activity. I don't know if it will improve again but it is fair to point out that I have had a TURP in 2017, RALP in 2021 and EBRT in 2024 so, quite a lot of interference down there!
Peter
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PSA rising 4 years after DaVinci radictal prostatectomy, PSMA/PET shows nothing, what to do?