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Brachytherapy outcome

User
Posted 03 Feb 2026 at 06:50

Hi guys, new to this place and looking for some advice on treatment options for my 3+4 (details provided against profile) and particularly brachytherapy which seems promising compared to other curative treatments in terms of cancer control and QoL factors. SBRT is also in the mix including MD-Linac but been warned off that by an RT guy who favours brachy (more cancer control due to higher dose delivered direct to prostate, etc). Not keen on surgery due to QoL risks and recovery time. Are there many of you who have faced a similar selection dilemma and who plumped for the RT option, and specifically brachytherapy?

User
Posted 10 Feb 2026 at 09:05

Hi Ade,

My Dad was about your age when he was diagnosed - treated with LDR BT and SBRT in combination. The SBRT was only because there was a risk of it having breached the capsule. He didn't experience bounce, just a straight line down to undetectable which he's still at today, over 20 years later!

I didn't consider HDR BT - it wasn't even proposed as an option by anyone I spoke to (and I spoke to more than most). I believe the most appropriate (non RP) treatment for you and I with our staging will always be LDR BT.

I know SBRT/EBRT has come on a lot in recent years but in my non medical opinion, it cannot possibly deliver as accurate a dose of radiation to such a small area as LDR BT. When they plan the LDR BT procedure, they use really cool software to work out the dose/number of seeds and where exactly to insert them in the prostate. They up the dose where they know the cancer definitely is and then saturate the rest of the prostate. The aim is to deliver an ultra focused high dose of radiation to just the prostate (and a couple of mm outside it). That way, the risk of radiation damage to anything else is minimal, but comprehensively delivered to the prostate.

Like I say, for me that's absolutely the most accurate way to deliver the radiation. The oncologist who performed my procedure does SBRT but for cancer contained within the prostate, he said he would always advise LDR BT for this reason.

I had mine done privately at Guys. It was actually a two man team who perfomed the procedure - my Urologist who is an absolute BT (and RARP) legend(!) and the oncologist who for want of a better way of describing it has seemingly learnt his trade from the urologist over the years. When I had my procedure done, they had done more than 2000 BT procedures over 20 years and in that time, had seen failure in only 20 cases - that's a failure rate of just 1% !! I also spoke to another very experienced BT specialist at the Christie in Manchester - I got exactly the same reasoning, explanation and similar (marginally worse) failure rates. I decided to go with the guys in London as I'd been under my Urologist's care there for several years since my first 'high' PSA reading (but negative biopsy originally)

I believe the seeds are always stranded. One of mine migrated to a seminal vesicle - I would never have known, it didn't and doesn't cause any problems, was told it wouldn't go anywhere else and that it was rare for them to migrate. The oncologist actually wryly commented when he saw it that 'and they claim we can't treat seminal vesicles with BT' 🤣

Yes, I discussed salvage options at length with both the urologist and oncologist. My primary advice to you however would be to absolutely not focus on the potential for failure (and the requirement therefore for salvage) as it's extremely unlikely given your staging that your treatment would fail. However, I understand it's natural and like you probably, initially the prospect of wanting to keep all options open caused me some consternation.

The urologist said that salvage RP is something that is absolutely possible after BT. More difficult yes but 100% possible - he has done salvage RP in some of the few cases where BT failed. I doubt the chances of normal sexual function afterwards would be great but normal urinary function stands a much better chance.

The oncologists comments re salvage had some of the greatest effect on me at focusing my mind as to what was the right primary treatment rather than what might be best from a salvage perspective. He said that whilst salvage RP might not be great, neither is salvage radiation treatment after failed RP. He said he does a lot of salvage RT after RP (remember about 30% of people who have RP will require salvage RT) and delivering salvage RT is difficult and often leads to more problems (urinary/sexual function) because it's not as focused and the prostate isn't there to protect other critical organs/body parts from the RT. So damage to the bladder/rectum etc is more likely.

Finally re salvage, when my PSA started to increase after the procedure, after a year of increases, I was just about to have another biopsy (consultant anxiety!!) and the consultants were talking about being able to do further LDR BT if necessary and the biopsy picked up where any residual cancer was. I'm not sure I remembered that being discussed as a salvage option pre-treatment but it turns out that it can be an effective option 2nd time round in the event of failure. Days before I was due to have the biopsy though, my PSA started to fall and we aborted it and continued to watch it fall over the next 12 months - my next PSA test is in a couple of months and I hope it's continued that trend! Certainly the oncologist signed me off back to the urologist's care for future monitoring, convinced I had/am experiencing nothing more than bounce.

No, I don't and have never felt the seeds inside me - there's absolutely no difference in sensation 'down there'. The procedure is so straightforward it's ridiculous really - I was in and out of hospital in a couple of hours. I stayed in London the rest of that 1st day but then travelled back up North on a train the next day and walked round a golf course with my son who was playing in a competition that day - no problems, no side effects. The urinary urgency did increase a bit over time as the radiation built up in the prostate but nothing serious, just occasionally a bit annoying to be going back and forth to the loo more than usual. That probably peaked at 3-4 months I guess (hard to remember now) but I would say by 10ish months, everything was back to completely normal. Sexual function was normal from day 1 (if you ignore the fact that you only have dry orgasms afterwards!). I was and still am prescribed Tadalafil which I take intermittently, not because I really need it but because actually, it makes me feel like a teenager again 😉🤣. Orgasms initially have a slightly different sensation (I presume because of the radiation damage and the fact there's no 'product'!) but over time, the sensation returns 100% to normal again.

Finally, as above, no HDR brachy was not proposed and I don't believe it would be appropriate or offered in your situation.

Cheers!
Paul

Edited by member 10 Feb 2026 at 09:11  | Reason: Not specified

User
Posted 06 Feb 2026 at 12:43

Hi Ade,

If you have a look at my profile and posts you can see my history and LDR Brachytherapy experience. Rather than put everything here I'll just say: Brachytherapy mid Sept 2025, a day in hospital, one follow up scan and PSA blood tests via GP.  Feel free to throw out questions as well.

I wish you and yours well, all the best.

Show Most Thanked Posts
User
Posted 03 Feb 2026 at 09:36

Hi Ade,

I had HDR Brachytherapy along with 15 sessions of radiotherapy, originally the plan was 20 sessions of EBRT but they suggested a last minute change (two days before) to 15 with brachy tacked on the end.

Having both does increase your chances of ED long term and there was mention of urinary strictures. It's worth asking if you can take a look in advance (if they don't offer it to you) at the form you need to sign before making a final decision. It lists all the side effects and chances of them occurring.

So far so good for me, but then its only been just over a year for me (EBRT Nov/Dec, Brachy end of December). Any bowel issues I had from the EBRT have cleared up too. 

The actual brachy procedure was a breeze, partly as it was done under general anesthetic! It was a day procedure, I went in at 7am for 8am op and was home just after lunch after proving I could wee and it ran clear of blood.

Are they suggesting any hormone therapy as well for you? That has cause the most side effects that have bothered me (on it for two years, six months to go. hopefully once I finish that I'll slooooowly return to normal.

My alternative was none nerve sparing surgery with a high likely hood of savage RT required, didn't fancy that!

All the best, choosing is very draining and worrying, but once done I felt a lot happier

User
Posted 03 Feb 2026 at 09:54

Hi Ade,

Welcome to the forum, mate. I was on active surveillance, for about two years. I had disease progression and eventually RARP.

This is an excellent video on treatment options, including brachytherapy, and the possible side effects of each.

https://youtu.be/zYTU94-8pTc?si=1Z29_l8rbTwF6DHl

Another excellent source is

https://prostatematters.co.uk/treatments-for-in-capsule-diagnoses-t1-t2/prostate-cancer-treatment-brachytherapy/

There are a few lads on here who've had brachytherapy. There have been numerous threads on this treatment, which without a functioning search facility, are now more difficult to find. Most seem very happy with it as a treatment option.

Please keep us updated.

Good luck, mate.👍

Edited by member 03 Feb 2026 at 10:14  | Reason: Add link

User
Posted 03 Feb 2026 at 11:12

I had the same treatment as John1975. That was nearly 8 years ago and all seems OK. I do have ED but blue pills sort that out.

Dave

User
Posted 03 Feb 2026 at 11:50

Thanks guys, appreciate the responses. I am told I don’t need any ADT as they don’t think the disease is progressed enough to need it which sounds good. It’s a real minefield with unconscious bias from the different experts with their preferred modalities. I did like the sound of HD brachy as a monotherapy (temporary seeds, good salvage options if needed) but does not seem to be available even privately in the UK unless in combination with EBRT which I am told I don’t need.

User
Posted 03 Feb 2026 at 14:21

Hi Ade

I had ADT, EBRT, and LDR Brachytherapy. I had no major issues with any one of those treatments (although ADT was annoying). Hopefully it's all worked for me, but only time will tell.

I wish you all the best in your decision and treatment.

 

 

User
Posted 03 Feb 2026 at 15:04

Hi Ade,

I had HDR Brachy and 20x EBRT. I liked the idea of the brachy as something that would properly nuke my PCa and all whilst I was asleep. I was kept in hospital overnight for it. The best thing about it for me was the sleep I got whilst anaesthetised, it was heaven, bliss 😁, so much so that I didn't want to wake up!

I wrote up my experience in my profile, but it is a long read. I did have a few impacts afterwards but these quickly cleared up. Strangely, the brachy was the only treatment that I was given a choice on. For me it was slotted in amongst Chemo, HT and EBRT.

Good luck with your choice.

Spongebob  

User
Posted 04 Feb 2026 at 17:51

Did you have any bad side effects from the permanent seeds? Burning and so on? I find it weird to have seeds giving off radiation inside you for 6 months or so but maybe you just forget about it after a while? Did your PSA fall as expected?

User
Posted 04 Feb 2026 at 17:54

Originally Posted by: Online Community Member

Hi Ade

I had ADT, EBRT, and LDR Brachytherapy. I had no major issues with any one of those treatments (although ADT was annoying). Hopefully it's all worked for me, but only time will tell.

I wish you all the best in your decision and treatment.

 

Gooose, Did you have any bad side effects from the permanent seeds? Burning and so on? I find it weird to have seeds giving off radiation inside you for 6 months or so but maybe you just forget about it after a while? Is your PSA falling as expected?

User
Posted 04 Feb 2026 at 18:24

Hi Ade,

Mine was HDR Brachy, so the radio for this was a temporary one-off concentrated nuke of the PCa. It’s different to LDR which I believe is the one that plants seeds to blast from within over a 6 month period.

Mine was ok, minor issues quickly restored.

Good luck with your choices.

User
Posted 05 Feb 2026 at 13:50
Quote:
Quote:

Gooose, Did you have any bad side effects from the permanent seeds? Burning and so on? I find it weird to have seeds giving off radiation inside you for 6 months or so but maybe you just forget about it after a while? Is your PSA falling as expected?

No "bad" side effects. There was post-treatment bladder/bowel irritation & fatigue as expected, but this was very temporary. I'm 20 months after that treatment now and everything is just fine.

I had 52 seeds permanently inserted with a 1/2 life of 60 days, but I think there was some small amounts of radiation being given off even after a year. Yes the concept of seeds giving off radiation inside me was a bit weird, but I soon got my head around it. Strangely, I'm going through airport security several times a week and never once did the seeds set off the detectors. I carry an NHS card with me to show security staff, but never needed to do so.

Just a note: the LDR (Low Dose Rate) is actually a higher total dose than the HDR (High Dose Rate) brachytherapy. Sounds counterintuitive I know, but true. Both variations of the treatment equally successful I believe. 

User
Posted 05 Feb 2026 at 22:08

Hi Ade

I Had HDR  Op in Feb 23, after i had 15 External Beam Raid plus 2 years on hormones. My cancer was stage 3 Gleason score of 9. All went very well treatment was done in one day, first class NHS treatment.

Edited by member 05 Feb 2026 at 22:12  | Reason: Not specified

User
Posted 06 Feb 2026 at 12:43

Hi Ade,

If you have a look at my profile and posts you can see my history and LDR Brachytherapy experience. Rather than put everything here I'll just say: Brachytherapy mid Sept 2025, a day in hospital, one follow up scan and PSA blood tests via GP.  Feel free to throw out questions as well.

I wish you and yours well, all the best.

User
Posted 08 Feb 2026 at 14:39
Hi Ade,

I had LDR BT nearly 3 years ago. Like you (and most others I suspect), I also struggled with making a treatment choice when given options.

My procedure and recovery were basically as expected/textbook. All very, very straightforward except for a little urinary urgency for 6 or so months but nothing that stopped me leading a normal life. I have no side effects at this point.

Unlike most BT'ers however, I appear to have had a couple of years of PSA Bounce where the PSA goes up initially instead of down! That can a bit anxiety inducing but I think most people's journeys are anyway to be honest.

Theres a lot more info about my journey in a couple of posts I've made on here which are linked in my bio.

Any questions, shout!

Good luck!

Paul

User
Posted 10 Feb 2026 at 05:48

Originally Posted by: Online Community Member
Hi Ade,

I had LDR BT nearly 3 years ago. Like you (and most others I suspect), I also struggled with making a treatment choice when given options.

My procedure and recovery were basically as expected/textbook. All very, very straightforward except for a little urinary urgency for 6 or so months but nothing that stopped me leading a normal life. I have no side effects at this point.

Unlike most BT'ers however, I appear to have had a couple of years of PSA Bounce where the PSA goes up initially instead of down! That can a bit anxiety inducing but I think most people's journeys are anyway to be honest.

Theres a lot more info about my journey in a couple of posts I've made on here which are linked in my bio.

Any questions, shout!

Good luck!
Paul

Thanks Paul for your response and very interesting journey with BT which I read with some alarm! I am nearly 61 so hopefully “bounce” is less of a thing for me than you as a younger guy! A few questions if I may:

- did you consider non-seed RT as I am currently agonising over SBRT vs LDR but worried about the lack of long term cancer control track record for the former? It was only until I met an older brachy oncologist that BT was even mentioned as an option to me, plus the American guy at PCRI is always talking it up

 - did you go to a high volume centre for BT. (PM me if you would rather not say publicly. I can’t PM yet as a new poster)

 - have you had any seeds which have “gone walkabouts” or do you not know? Were they “stranded” in your case?

 - did they ever talk to you pre-treatment about salvage options as that seems not to be BT’s strongest suit?

 - do you ”feel” the seeds inside you other than a bit of urinary bother initially?

 - was HDR brachy ever proposed to you? they tell me that they don’t run such program for intermediate disease like mine

Thanks again for sharing your journey which is enormously helpful.

Edited by member 10 Feb 2026 at 05:50  | Reason: Not specified

User
Posted 10 Feb 2026 at 09:05

Hi Ade,

My Dad was about your age when he was diagnosed - treated with LDR BT and SBRT in combination. The SBRT was only because there was a risk of it having breached the capsule. He didn't experience bounce, just a straight line down to undetectable which he's still at today, over 20 years later!

I didn't consider HDR BT - it wasn't even proposed as an option by anyone I spoke to (and I spoke to more than most). I believe the most appropriate (non RP) treatment for you and I with our staging will always be LDR BT.

I know SBRT/EBRT has come on a lot in recent years but in my non medical opinion, it cannot possibly deliver as accurate a dose of radiation to such a small area as LDR BT. When they plan the LDR BT procedure, they use really cool software to work out the dose/number of seeds and where exactly to insert them in the prostate. They up the dose where they know the cancer definitely is and then saturate the rest of the prostate. The aim is to deliver an ultra focused high dose of radiation to just the prostate (and a couple of mm outside it). That way, the risk of radiation damage to anything else is minimal, but comprehensively delivered to the prostate.

Like I say, for me that's absolutely the most accurate way to deliver the radiation. The oncologist who performed my procedure does SBRT but for cancer contained within the prostate, he said he would always advise LDR BT for this reason.

I had mine done privately at Guys. It was actually a two man team who perfomed the procedure - my Urologist who is an absolute BT (and RARP) legend(!) and the oncologist who for want of a better way of describing it has seemingly learnt his trade from the urologist over the years. When I had my procedure done, they had done more than 2000 BT procedures over 20 years and in that time, had seen failure in only 20 cases - that's a failure rate of just 1% !! I also spoke to another very experienced BT specialist at the Christie in Manchester - I got exactly the same reasoning, explanation and similar (marginally worse) failure rates. I decided to go with the guys in London as I'd been under my Urologist's care there for several years since my first 'high' PSA reading (but negative biopsy originally)

I believe the seeds are always stranded. One of mine migrated to a seminal vesicle - I would never have known, it didn't and doesn't cause any problems, was told it wouldn't go anywhere else and that it was rare for them to migrate. The oncologist actually wryly commented when he saw it that 'and they claim we can't treat seminal vesicles with BT' 🤣

Yes, I discussed salvage options at length with both the urologist and oncologist. My primary advice to you however would be to absolutely not focus on the potential for failure (and the requirement therefore for salvage) as it's extremely unlikely given your staging that your treatment would fail. However, I understand it's natural and like you probably, initially the prospect of wanting to keep all options open caused me some consternation.

The urologist said that salvage RP is something that is absolutely possible after BT. More difficult yes but 100% possible - he has done salvage RP in some of the few cases where BT failed. I doubt the chances of normal sexual function afterwards would be great but normal urinary function stands a much better chance.

The oncologists comments re salvage had some of the greatest effect on me at focusing my mind as to what was the right primary treatment rather than what might be best from a salvage perspective. He said that whilst salvage RP might not be great, neither is salvage radiation treatment after failed RP. He said he does a lot of salvage RT after RP (remember about 30% of people who have RP will require salvage RT) and delivering salvage RT is difficult and often leads to more problems (urinary/sexual function) because it's not as focused and the prostate isn't there to protect other critical organs/body parts from the RT. So damage to the bladder/rectum etc is more likely.

Finally re salvage, when my PSA started to increase after the procedure, after a year of increases, I was just about to have another biopsy (consultant anxiety!!) and the consultants were talking about being able to do further LDR BT if necessary and the biopsy picked up where any residual cancer was. I'm not sure I remembered that being discussed as a salvage option pre-treatment but it turns out that it can be an effective option 2nd time round in the event of failure. Days before I was due to have the biopsy though, my PSA started to fall and we aborted it and continued to watch it fall over the next 12 months - my next PSA test is in a couple of months and I hope it's continued that trend! Certainly the oncologist signed me off back to the urologist's care for future monitoring, convinced I had/am experiencing nothing more than bounce.

No, I don't and have never felt the seeds inside me - there's absolutely no difference in sensation 'down there'. The procedure is so straightforward it's ridiculous really - I was in and out of hospital in a couple of hours. I stayed in London the rest of that 1st day but then travelled back up North on a train the next day and walked round a golf course with my son who was playing in a competition that day - no problems, no side effects. The urinary urgency did increase a bit over time as the radiation built up in the prostate but nothing serious, just occasionally a bit annoying to be going back and forth to the loo more than usual. That probably peaked at 3-4 months I guess (hard to remember now) but I would say by 10ish months, everything was back to completely normal. Sexual function was normal from day 1 (if you ignore the fact that you only have dry orgasms afterwards!). I was and still am prescribed Tadalafil which I take intermittently, not because I really need it but because actually, it makes me feel like a teenager again 😉🤣. Orgasms initially have a slightly different sensation (I presume because of the radiation damage and the fact there's no 'product'!) but over time, the sensation returns 100% to normal again.

Finally, as above, no HDR brachy was not proposed and I don't believe it would be appropriate or offered in your situation.

Cheers!
Paul

Edited by member 10 Feb 2026 at 09:11  | Reason: Not specified

User
Posted 10 Feb 2026 at 12:11

Paul, thanks enormously for your comprehensive response which helps a lot.

I probably saw the same experienced BT guy as you at Christie’s recently. Interesting about Guys, as the London surgeon I met in Dec after my biopsy referred to their fantastic BT team in a YouTube video which he could salvage after, so I was thinking of them even if I am Cheshire-based. My urologist was based in London when I was dreaming of focal therapy a year or so ago so keen to stay within his team as he is very well-known and well-connected.

If you could PM me with the name of the BT guy at Guys as I will reach out to him!

User
Posted 10 Feb 2026 at 16:51

No problem Ade - it's a small world, I'm also in Cheshire! DM sent.

User
Posted 10 Feb 2026 at 18:16

Thanks Paul for the PM although I still can’t respond privately! I am based in Crewe so not far away from your neck of the woods, and easy to get to London. I will look up the guy you mentioned as he is likely to be the guy my would-be Guys surgeon mentioned in a video. Not sure how many posts I need to make before I can PM.

User
Posted 10 Feb 2026 at 18:18

The Christies guy I saw was not the same as the one you saw but of a similar “vintage” and works in same team no doubt. I did like him also.

User
Posted 10 Feb 2026 at 20:10
Nice, London is only a hop skip and a jump from Crewe! Although the Christie is an absolutely top class centre that we're lucky to have.

Think it's 10 posts before DM's are allowed but someone with better knowledge might chip in!

User
Posted 11 Feb 2026 at 05:26

Paul, referring to your PM, do you know whether the rectal spacer is done as standard at Guys with BT as that does not seem to be the case at most other places nowadays? I do like the sound of that additional protection. 

User
Posted 11 Feb 2026 at 07:26
Hi

Husband is having RT in June at the Churchill, Oxford. I asked about a rectal spacer when we saw the oncologist who deals with RT. He said they'd decided not to do it, as could be more of a hindrance than a benefit as made targeting more difficult.

I was impressed with this chap so had confidence in what he said. I can't recall exactly how he phrased it tbh

User
Posted 11 Feb 2026 at 07:50

Originally Posted by: Online Community Member

Paul, referring to your PM, do you know whether the rectal spacer is done as standard at Guys with BT as that does not seem to be the case at most other places nowadays? I do like the sound of that additional protection. 

Yes, it was standard procedure with my consultants 3 years ago. I presume it still is.

I can understand why it might be different for EBRT in terms of affecting targeting but for BT, I can't see a downside (although if I remember, they didn't use it at another centre I visited. Perhaps because it was inserted by a surgeon rather than an oncologist who may not have the specific surgical skill to do so -  I don't know, just guessing!)

Edited by member 11 Feb 2026 at 08:33  | Reason: Removed reference to a specific centre of excellence

User
Posted 11 Feb 2026 at 08:01
This wasn't anything to do with the oncologists skill. He said it was a decision as a team they'd taken . This was in January 2026 so very recent.

I'm not keen on celebrating any particular surgeon or hospital as it may make others feel less confident, but I d hope the Oxford University hospital is quite up to date.

User
Posted 11 Feb 2026 at 08:31
Apologies, I wasn't questioning anyone's skill or trying to big up/put anyone down. I was simply musing as to whether insertion of a rectal spacer required a surgical skill set not commonly held by oncologists because mine was inserted by a urologist whose only job during the procedure was the insertion of the spacer. 🤷‍♂️

I also said I could see why use of a spacer might not be as desirable for treatment with SBRT/EBRT as the radiation has to be delivered/targeted into the prostate but with BT it's already there so the spacer is just protecting from the radiation the seeds are already giving off.

I also never generally mention individual centres or people but if asked directly, I'm happy to share my own experience on the basis that it's just that - my experience, not the only experience.

Once again apologies if I seemed to be biased in my musings about one centre of excellence over another - it was not my intention and I'll remove reference to them in my earlier posts.

User
Posted 11 Feb 2026 at 09:28
No that's fine, I didn't mean it to sound that critical. I will ask him again. Or chat with husband about it. We all just want the very best outcome don't we. Please don't delete anything.
User
Posted 16 Feb 2026 at 17:41

Hi Ade.

I'm just shy of a year since I had my bracratherapy, my PSA is now down to 1.9 from a high of 8.6, 

You'll see from my threads how Paul and the lads helped me along the way with everything.

Bryan

User
Posted 27 Mar 2026 at 14:36

Hi guys

 Just an update after my LD brachy procedure two days ago. Procedure went well with good dosimetry from 70 seeds covering the whole gland, with an extra coating for the tumours whilst sparing the urethra as much as possible. I also had the SpaceOar rectal spacer inserted and had a catheter inserted to ensure the bladder was clear of seeds, all whilst under GA for around 90 minutes. After a couple of voids, I was free to leave mid-afternoon after arriving at 7.30am. I have felt a bit tired today, and a bit sore down below, but not much worse than after a biopsy and not surprising after the 29 needles they inserted through the perineum. Urination was a bit hesitant on day 1 but has been fine ever since, virtually normal I would say.

 I have a scan in 2-3 weeks time to check on the seeds’ placement.

 Thanks everyone for your replies on this thread.

 
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