Notification

Error

Decapeptyl plus Apalutamide or similar

Email this conversation Print this conversation
User
Posted 15 Mar 2026 at 11:48

Husband has been on Decapeptyl for four months. He is coping well with side effects etc and we're just getting on with life. After a few delays. Monitoring BP, waiting for appointments etc, he is supposed to be adding Apalutamide. He had a good reduction in his PSA after 3 weeks, from 7.1 to 1.7 . I'm just wondering how severe the side effects might be from adding the Apalutamide and what difference to what he's experiencing already 

User
Posted 15 Mar 2026 at 16:15
Thank you Chris. So far husband, to me, has had negligible side effects. He has sweat on his forehead at times, but sleeps the same. He does all the same things. I'm afraid we're night owls and got to bed about 12 midnight most nights. He walks several miles a day. Hes been to the allotment today and is cooking dinner and getting ready to take a neighboyrs inexhaustible dog on a ling walk, despite the rain. He has now got ED but Sildenafil 50mg is still working fine.. He has taken to using the vacuum pump after a shower, and commented how well it was going today. He's definitely not shrinking at present. He does have high BP, as do I , I think the result of 40+ years teaching and caring for a son with a " severe enduring mental illness". He very non emotional, which is why we work so well. Because I'm high emotion. I just hope we can cope with any extra changes.
User
Posted 15 Mar 2026 at 16:16

Ps well done on PSA result. It sounds very good. Long may it continue x

Show Most Thanked Posts
User
Posted 15 Mar 2026 at 12:15
I declined the early Apalutamide and it’s left in the bag for me. I’ve been on Decapeptyl for exactly 5 yrs with very tolerable side effects but it’s just beginning to fail. It’s your choice but hearing from others , taking the 2 together vastly affects your QOL. I’ve put that first all the way. Good luck
User
Posted 15 Mar 2026 at 12:20
Thank you. The plan is to go on it before radiotherapy so we can chat with oncologist about this
User
Posted 15 Mar 2026 at 12:24
Ps I think he wants to take it as it will increase the chances of recurrence. The PC is confined but there was a trace in one node. He's been told the plan is to cure and to be on HT for 2 years. We know it's something not a given and QOL is a big issue, he's 74 and very fit and active, but he also wants the best chance of getting rid of the PC so he will take it
User
Posted 15 Mar 2026 at 16:01

Antoinette, we are probably all affected in different ways. I am 74 and not fit. I have been on decapeptyl and apalutamide for just under a year. For me it was not good , mainly hot flushes and fatigue, add in mood swings and a bit of depression. The blood pressure went up. I had to stop the apalutamide for a while to get the blood pressure under control. I restarted the apalutamide 3 weeks ago  on  half dosage (120mg) ,no hot flushes, no fatigue and far better mentally. I am on them both for life or until they stop working. PSA a few days ago was 0.03.

Thanks Chris.

User
Posted 15 Mar 2026 at 16:15
Thank you Chris. So far husband, to me, has had negligible side effects. He has sweat on his forehead at times, but sleeps the same. He does all the same things. I'm afraid we're night owls and got to bed about 12 midnight most nights. He walks several miles a day. Hes been to the allotment today and is cooking dinner and getting ready to take a neighboyrs inexhaustible dog on a ling walk, despite the rain. He has now got ED but Sildenafil 50mg is still working fine.. He has taken to using the vacuum pump after a shower, and commented how well it was going today. He's definitely not shrinking at present. He does have high BP, as do I , I think the result of 40+ years teaching and caring for a son with a " severe enduring mental illness". He very non emotional, which is why we work so well. Because I'm high emotion. I just hope we can cope with any extra changes.
User
Posted 15 Mar 2026 at 16:16

Ps well done on PSA result. It sounds very good. Long may it continue x

 
Forum Jump  
Email this conversation Print this conversation

Join the online community now.

Click through to become a member and gain access to support, information and real time replies.




MenuTop ▲
©2026 Prostate Cancer UK