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Relugolix plus Abiraterone & Steroid anyone?

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User
Posted 29 Apr 2026 at 21:43

Hi


we had our first oncology meeting today - great news is that Pet scan showed no spread, so we were told it’s 3 years Relugolix and in a months time they are adding Abiraterone and a steroid.


We have another consultation for that, but wondered if anyone has experienced this combination (along with blood thinners, BP & Cholesterol medication for Atrial Fibrillation and stents.) 


What side effects can we expect to encounter? Radiotherapy planned for 6 months time 20 sessions. John is Gleason 4-4, but only found in 2 of 18 samples at biopsy. He’s 69 (tomorrow !) and generally fit and keeps himself active with cardio exercises. Resistance workouts, walking and golf - plus we have reduced our alcohol consumption since diagnosis and I cook very healthy food. 
Any recommendations to keep him as fit and healthy as we can during treatment?


Tracey


 

User
Posted 30 Apr 2026 at 18:56
I wasnt on same treatment but I had 3 years Zoladex and 32 sessions of RT to treat Gleason 8 (upped to 9 after TURP) PSA 21 slight spread to seminal vesicles. Included in my treat was 2 years on trial with abiraterone, enzalutimide, prednisolone (steroid). The steroid is included to combat some of side effects of abiraterone I believe.
I did suffer many of the expected side effects but accepted them really and they did go a while after treatment finished. It is tempting to get on couch and stay on it as treatment does really cause fatigue but it is really good to get out and about.
I started treatment in 2015 aged 59 and all good up to now.
People are affected differently some worse than others but generally fatigue, muscle loss, libido I think are most common.
Peter
User
Posted 01 May 2026 at 03:58

Hi again, Tracey.


Great news that John's scan was clear. I'm very pleased for both of you.


I've got a 62 year old mate who's on Relugolix and just finished 35 sessions of radiotherapy salvage treatment, to treat a recurrence following his prostatectomy.


He drinks like a fish, smokes like a chimney, lives on chips and curries and his only exercise is walking to the pub or takeaway.  He felt fatigued during his treatment, but he's recovered now and returned to work a month ago. If he coped okay with the treatment I'm sure John will be fine. 🙂


Good luck. 👍 

Edited by member 01 May 2026 at 04:04  | Reason: Typo

User
Posted 01 May 2026 at 07:55

Thanks Adrian, yes the relief at no spread was immense, the best birthday present we could have wished for! Well John is definitely a lot healthier than your mate so I’m sure we’ll cope just fine - after all, we don’t have a choice if we want him cured. 😁xxx

User
Posted 01 May 2026 at 15:11
Giving up alcohol and eating "healthy"? Makes me slightly concerned about his quality of life!
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User
Posted 30 Apr 2026 at 18:56
I wasnt on same treatment but I had 3 years Zoladex and 32 sessions of RT to treat Gleason 8 (upped to 9 after TURP) PSA 21 slight spread to seminal vesicles. Included in my treat was 2 years on trial with abiraterone, enzalutimide, prednisolone (steroid). The steroid is included to combat some of side effects of abiraterone I believe.
I did suffer many of the expected side effects but accepted them really and they did go a while after treatment finished. It is tempting to get on couch and stay on it as treatment does really cause fatigue but it is really good to get out and about.
I started treatment in 2015 aged 59 and all good up to now.
People are affected differently some worse than others but generally fatigue, muscle loss, libido I think are most common.
Peter
User
Posted 01 May 2026 at 03:58

Hi again, Tracey.


Great news that John's scan was clear. I'm very pleased for both of you.


I've got a 62 year old mate who's on Relugolix and just finished 35 sessions of radiotherapy salvage treatment, to treat a recurrence following his prostatectomy.


He drinks like a fish, smokes like a chimney, lives on chips and curries and his only exercise is walking to the pub or takeaway.  He felt fatigued during his treatment, but he's recovered now and returned to work a month ago. If he coped okay with the treatment I'm sure John will be fine. 🙂


Good luck. 👍 

Edited by member 01 May 2026 at 04:04  | Reason: Typo

User
Posted 01 May 2026 at 07:55

Thanks Adrian, yes the relief at no spread was immense, the best birthday present we could have wished for! Well John is definitely a lot healthier than your mate so I’m sure we’ll cope just fine - after all, we don’t have a choice if we want him cured. 😁xxx

User
Posted 01 May 2026 at 15:11
Giving up alcohol and eating "healthy"? Makes me slightly concerned about his quality of life!
 
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