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Visceral Mets treatment

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User
Posted 01 May 2026 at 17:48

Hi All,

Looking for someone who's had experience with advanced cancer that's moved to the liver and lungs. Things are not looking great, but want to see if anyone has had successful chemotherapy. Due to start on 11th May with 1 of 6 rounds of Paclitaxel and Carboplatin. Trouble is, husband is very slim due to massive weight loss, already has significant fatigue, and gastric issues. Just hoping someone has a positive story to share. 

Thanks 

User
Posted 01 May 2026 at 21:29

Nothing to add on medial advice but my heart goes out to you and your hubby and really hope you are doing okay yourself. Hope he gets the best treatment available in his situation.

Never give in, never, never,never.

 

User
Posted 07 May 2026 at 01:24

Hello again Rachel,

                                 Well that adds a bit more complexity, but I think you will find that histotripsy would still be in the Oncology thinking along of course with addressing the Colon Ca issue, which is most likley close to the liver. Also be mindful that the Liver can regenerate following resection/abaltion. Of course your husband's general state of heath will also be very salient in the Oncology team's considerations.

                                Rachel when you are having the Histo consult ask about the effective treatment tumour depth. The early machines in the US had a limit of 14mm at the time. I understand the newer machines can go a tad deeper.

Edited by member 07 May 2026 at 01:57  | Reason: Not specified

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User
Posted 01 May 2026 at 21:29

Nothing to add on medial advice but my heart goes out to you and your hubby and really hope you are doing okay yourself. Hope he gets the best treatment available in his situation.

Never give in, never, never,never.

 

User
Posted 02 May 2026 at 02:28

Hello Missus,

                       You may care to also lookup Histotripsy. Basically high intensity ultrasound able to eliminate both primary and met tumours. Relatively new in Australia. Expensive. Side effects minimal. Efficacy, satisfactory for current malignancies. Recurrence is of course the mitigating consideration. John Hopkins Hospital in the US has some good info on their website. Availability in UK? I have no idea.

User
Posted 02 May 2026 at 02:41

Thank you for that. I'll look into it. Always hoping something can be done. 

Best wishes to you 

User
Posted 02 May 2026 at 02:52

Wow. That's definitely something that I will discuss with the oncologist. It's available at our hospital!! Long waiting list but it looks like he might be eligible. Thank you so much for your information. Some hope for him🙏

User
Posted 02 May 2026 at 05:58

Well that is a surprise that it is already available in the UK, and even more so at your local hospital. Do let us know your husband's eligibility and treatment timeframe. I think there may be a few others on here who would also be most interested.

User
Posted 02 May 2026 at 07:44

There are several NHS hospitals offering it but we certainly haven't been told about it.

https://ammf.org.uk/wp-content/uploads/2025/12/Histotripsy-FAQ-CUH-October-2025-V1.pdf

He might not meet the eligibility criteria due to the extent and size of his mets, but I'll still discuss. Our oncologist was very shocked about the liver and lung involvement. These were not taken particularly seriously when seen on the PSMA PET scans as they weren't avid lesions, so thought to be benign lung nodules (despite rapid growth) and liver cysts. They were only spotted on a CT scan by a different medical team. 

Anyway, that's not relevant to your information. So thanks again. 

Rachel 

 

Edited by member 02 May 2026 at 07:45  | Reason: Not specified

User
Posted 03 May 2026 at 09:49

Hello again Rachel,

                                 Interesting patient information pdf, particularly noting the tumour size range 1.5 to 0.6 mm limit. Given the technology is new I think your NHS is hedging their bets a bit. Studies I have read thus far indicate an upper tumour size limit of 3cm, plus proximal to adjacent structures is not a mitigating clinical issue. The other issue being life span, currently estimated greater than 3 months. So we are talking end stage therapy, with thus far, satisfactory results (12 to 24 months) depending upon ablation efficacy. And the therapy can be repeated at future intervals. Do let us know the outcome of your discussions.

Edited by member 03 May 2026 at 09:55  | Reason: Not specified

User
Posted 06 May 2026 at 17:58

Hi Jft,

Just to let you know, turns out that the liver mets is not from prostate cancer and is in fact a separate colorectal cancer. Difficult to get our heads round. Seeing the new onco team next week and will find out about potential treatments and possibility of Histotripsy. Btw, our hospital is the first one in Europe to offer this and the consultant today saw this as a potential pathway. 

https://www.cuh.nhs.uk/news/addenbrookes-begins-innovative-liver-cancer-treatment-for-first-nhs-patients-in-europe/

 

User
Posted 07 May 2026 at 01:24

Hello again Rachel,

                                 Well that adds a bit more complexity, but I think you will find that histotripsy would still be in the Oncology thinking along of course with addressing the Colon Ca issue, which is most likley close to the liver. Also be mindful that the Liver can regenerate following resection/abaltion. Of course your husband's general state of heath will also be very salient in the Oncology team's considerations.

                                Rachel when you are having the Histo consult ask about the effective treatment tumour depth. The early machines in the US had a limit of 14mm at the time. I understand the newer machines can go a tad deeper.

Edited by member 07 May 2026 at 01:57  | Reason: Not specified

User
Posted 08 May 2026 at 19:25

Hello again Jfd. 

No go on the Histotripsy. I didn't get to discuss it in any detail to be of benefit to others here. The colorectal oncologist said it will not be an option for my husband unfortunately, and is very limited at present to a very small number of eligible candidates. Thanks again and best of luck with your personal journey..

 
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