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German Clinics request for people''s experiences

User
Posted 24 May 2026 at 13:18

Hello everybody, my partner has recently been diagnosed with metastatic cancer and we are getting our heads round all the different options and what to do.  I have found this site extremely helpful in reading about all the different experiences and options, although it has also been a lot to go through and understand.  I am just beyond the point of googling the abbreviations : ) It has spread to the lymph nodes and 2 ribs and is more complicated because he has a big prostate due to BPH.  

Would anybody who has been to the clinics in Germany mind sharing their experiences and what they had done?  Some treatments we have read about the people over there seem to have more experience and we would like to explore everything.  My partner has a very large prostate which doesn't make things easier - we were hoping that if something was found it would just be removed but this was before we knew it wasn't localised.

We have amazing support and care in the hospitals in this country and I am well aware of this and we will probably stay local but we are in the gathering information phase and would like to know everything that is available.

Thank you for your time and what a wonderful community this is, I am hoping my partner will join but at the moment he is feeling a bit overwhelmed as I am sure you will appreciate.

User
Posted 24 May 2026 at 18:32

Hello SunnyLouLou

I live in France - and have been treated in Germany (near Frankfurt) with first immunotherapy and then with 177Lu therapy

#1  German clinics are not so cheap.  I used all my savings for these treatments.

For the immunotherapy - I had my prostate removed with electrochemotherapy for prostate cancer (ECT).  This was coupled to doses of Keytruda in an effort to make my immune system act on the antigenes produced by the ECT.  It certainly removed the prostate without too much problem - and my PSA dropped from 19 to ~ 3 ng/ml  but then it started to rise again -  so I had a PSMA PET scan and found that this treatment had not affected the cancer in the bones.

So I then what to do.  I decided on 177Lu-PSMA treatment.  The problem that this treatment is not really available unless it is the last chance .. ie you have tried all other treatments and have ended up with castration resistant prostate cancer running wild ...  and I was not in this position.  However I found a clinic near Frankfurt - (different from the immunotherapy) who were able to treat me on compassionate grounds.  A visit there involved a PET scan - treatment with the 177LU - then a SPECT scan ... and you had to spend two days in the clinic due to German law.  I was also taking enzolutamide.  Two doses of 177Lu resulted with PSA < 0.01 ng/ml and a clear PET scan 6 months later.   

This is still the situation and I am not fully sure which part of the treatment did the most to help - but 177Lu seems to be good (for me) especially if used early in the treatment cycle.

Good luck

Crispin

User
Posted 24 May 2026 at 23:42

Thank you Crispin, this is very helpful and it sounds like you have had some similarities with us.  

Did you have all your scans and biopsy in Germany before treatment or send them that information first.  I have researched that they do the biopsy under MRI there so it is a slightly different approach. 

We spoke to the oncologist here about using 177Lu-PSMA treatment and were told exactly that.  It was only available for last chance treatment and we were told it wasn't effective early on but it sounds like you have had a different experience.  So this isn't something they use early in Germany either?  If you don't mind me asking - why did you go for this as an early option?  

Were your lymph nodes also affected?  

Well done, it sounds like you had a very good result for your efforts.  Thank you so much for sharing your experience, I am very grateful.

We will gather the information we can and discuss with specialists before making any decisions. 

Kind regards

Loulou

User
Posted 25 May 2026 at 07:01

Hello Loulou

I had a rising psa and an urologist following this in France.  I had an MRI in France that found a tumour (PIRADS of 5) but the following biopsy missed the cancer - so the urologist sent me home saying there was no cancer.  However the PSA kept rising and I had a second MRI a year later ... I was meant to have a second biopsy but somehow this was lost in paperwork ..  so I payed for a PSMA-PET scan in Geneva.  This showed the metastatic cancer - however although it was in my pelvic bone, spine etc there was no lymph node involvement.

I went to the Gustav Rossy hospital in Paris - and the suggested treatment was radiation treatment plus hormone treatment.  Personally I do not fell confident with radiation treatment since it can damage things that should not be damaged (this is my opinion).  I also had prostate cancer in my prostate -  so I wanted this removed (since it is the source of the cancer) but I wanted to use these cancer cells to train my immune system  to attack the cancer cells - hence the ECT + immunotherapy.  I am not sure if it had any effect on my immune system - but maybe it did (who knows).  I had a biopsy during the ECT that only showed up in a 700 micron area of a 15 mm core as Glesson 4+4 (4 cores taken)   My PSA dropped very quickly but then started to rise again...  so I had another PET scan in Geneva.  This showed that the prostate had been successfully treated but not the bone metastasis.

I asked for advice from the German clinic - they suggested more immunotherapy or 177Lu treatment.   Gustav Rossy in Paris said I could join their trial in Paris but I need to take hormone medication for 4 months -  and then I would have a 50:50 chance of being treated with 177Lu - or of being part of the untreated group.   This I did not find attractive -  so I started a search for 177Lu treatment where I could have it before I was castration resistant, etc.  And with the help of the immunotherapy clinic I found somewhere willing to treat me...   and here I am about a year onwards from the last 177Lu treatment.  I have now found a French oncologist to follow me within the french health system since the medication is so expensive; she sees me every 3 months.

In France and Switzerland:  they give you a CD of the scan directly after the scan : MRI and PET scan : that I sent to the German (and other) clinics when i was seeking advice.

i am not sure of my status at present - certainly deep remission but whether 'cured' is too early to say.  The 177Lu people say that they have ~ 3% cure rate (i.e. psa of 0 after 10 years ).

This activated PSMA treatments was initially performed with Actinium (an alpha emitter) that used to wipe out the saliva glands - so this was only used as the last chance (although it was impressive in its efficacy).  Thus there was this worry about 177Lu (a beta emitter) : however for some reason (I have my theories on this) the saliva glands appear to survive.  There are now trials with using 177Lu-PSMA at an early stage [Maybe the FDA has approved this treatment at an early stage in the US] so I do not think your oncologist is completely correct.

Good luck with your search for treatment -  everyone is different so it is not clear the response of your partner would follow the same path as mine - I think it is great that this forum exists where people can talk.  Please keep us informed.

Crispin

Edited by member 29 May 2026 at 07:43  | Reason: changed oncologist to urologist at start of post

User
Posted 25 May 2026 at 13:22

Thank you Cristin for taking the time to provide such a detailed and comprehensive reply.

We are still understanding the language related to all this so I will have to fully go through what you have shared and then get back to you.

This website is great for being able to share and understand better what is going on.

Thank you, you will hear from us again soon.

Kind regards

Loulou

 
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