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Darolutamide and Relugolix , feeling unwell

User
Posted 08 Jun 2026 at 09:10

Hi all,

I was just wondering if anyone out there has a similar experience, 
Last year I had 2 recurrences, first to my Spine , only one spot which was blasted with targeted RT , the second was to left hip , right 3rd rib and 80-20% skull .

I was placed on these drugs which had a amazing response, PSA dropped to 0.32 from over 13 within a month , I had a pet scan which showed cancer was reducing but still there , it was considered that the highlight on my skull could be inflammation and not cancer however only way to know was to have a biopsy which I didn’t want. I was feeling great .

Fast forward a few months , especially in the last 2 weeks , I feel unwell, pain in my shoulders and back , and generally feeling unwell . 
The question Im asking , is this an effect of the drugs , is the Cancer finding a way past the drugs , my mood seems to be dropping and feeling very down ATM ,

Thanks for your time .

User
Posted 08 Jun 2026 at 09:52

Good morning Sheep62

My own personal experience of hormone therapy (Zoladex and Darolutamide) is that it can "lower mood". I have found that it occurs intermittently for short periods - never more than half a day or so.  I "feel sad" at times.  The effect of the HT is to cut testosterone and that impacts significantly across many areas of the male body.

I take plenty of exercise - walking, weights, resistance bands, indoor bike - and this improves mood (once the exhaustion has been gotten over!!!) and fights fatigue.  This all contributes to feeling better overall.

However, all that said, a chat with your GP or Consultant is always a good idea if things are feeling "off". 

 

Best wishes

Best wishes - stay positive

CeePee

 
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