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HIFU/Nanoknife

User
Posted 01 Jul 2026 at 13:35

Hi everyone,

My diagnosis is as follows:

T3a N0 M0

Gleeson 7 (4+3) GG3

CPG4

Cribriform pattern present

2 tumours, 1 Capsular breach but EPE No

the NHS are unable to take out my prostate which I didn't want anyway, so i'm scheduled for hormone therapy and RT.

The NHS seems to only offer Hifu/Nanoknife for T1 & T2. But I have contacted a private clinic today who say that they can treat my stage 3, has anyone had similar diagnosis to me and had this treatment?

 

Many thanks 

 

User
Posted 02 Jul 2026 at 02:33

Sorry you join us due to your diagnosis. There are very few members who have posted that they had Focal Treatment and of these some like myself had it, (HIFU in my case), as a salvage treatment for failed Radiotherapy. So you may not get a great response. You are also in a bit of a grey area as regards how far immediately outside the Prostate Focal treatment will be given. I think this link is relevant. https://www.nature.com/articles/s41598-021-93340-3.

It is not clear whether you have had your MRI, Biopsy and histology considered by a specialist Focal Therapist to ascertain your suitability for one of the forms of treatment. If you are seriously considering this and you have not yet done so, I suggest you get a referral to UCLH in London who have the most experience in the UK. They may treat you within the NHS or provide a more informed view on treating privately.

I was originally graded Gleason 3+4=7 but after previous treatment RT, this was subsequently changed to 4+3=7. My staging was T3A. I had two applications of HIFU within a study on the NHS. (Two applications are sometimes required with HIFU). It is a very easy procedure. I am presently sub PSA 1 some 19 years after initial diagnosis with clear MRI this March.

Do let us know how you get on.

Edited by member 02 Jul 2026 at 02:35  | Reason: to highlight link

Barry
User
Posted 03 Jul 2026 at 13:51
Hi Barry,

Thank you for your reply, 19 years on, that's awesome!

Our consultant referred us to UCLH and they've accepted it so we're awaiting an appointment, HIFU doesn't look likely, (think our consultant wants the prostate out) but we have to push all the doors don't we.

People are telling me that the HIFU wont sort any microscopic spores that have gone walkabout and not picked up on an MRI, but i'm thinking couldn't they do HIFU followed by short course of hormone therapy and RT?

Thank you

Donna

User
Posted 03 Jul 2026 at 15:13

Originally Posted by: Online Community Member
Hi Barry,

People are telling me that the HIFU wont sort any microscopic spores that have gone walkabout and not picked up on an MRI, but i'm thinking couldn't they do HIFU followed by short course of hormone therapy and RT?

Thank you

Donna

The foregoing is true of Focal and Prostatectomy.  I was told they would not treat with  Focal Therapy other than if cancer was believed to be within the Prostate or immediately outside as described in the link I supplied earlier. UCLH were not going to give me a second HIFU because some Choline in a scan was showing in an Iliac node. However, the size and shape raised doubt and a subsequent PSMA scan I had didn't show cancer in the suspect node and I got my second HIFU.  I would think if cancer is suspected clear of the Prostate, they would want to treat all with RT.  But it all depends on what the experts see and believe because there are different ways to tackle it, some more suited to an individual than others.  Suggest you ask to be told all options and follow ups if an option does not effectively work.  

Barry
 
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