Next step ? Radium 223

User

Posted 11 Jul 2026 at 16:36

My husband has been referred for this as he has extensive active bony mets.

He was diagnosed in Jan 25 with stage 4, Gleason 9.

Apalutamide failed after 6 months and docetaxcel didnt work sadly.

He had a displaced subcapital fracture ( top of femur) due to the cancer and had surgery ( total hip replacement) on 17th June.

Has anyone experience of radium 223?

Thanks

User

Posted 11 Jul 2026 at 20:42

I had great hopes for Ra-223 but it was not to be for my OH. He had his first Ra-223 injection on 9 Sept 2025 with no side effects. Blood tests are needed before any infusion and that was all okay but PSA kept increasing from 61.3 to 98.5 by 3rd infusion so it wasn;'t working. He had 4 infusions and then they were stopped because of cancer progression. So don't worry about side effects because everyone is really on board with impact on blood profile. It has good reviews of helping but just didn't work in our case. Good luck!

User

Posted 11 Jul 2026 at 20:55

Thanks very much for the info.

Sorry it didnt help your OH

I think for my OH, it is hoping it will slow down the bony mets and therefore help with pain relief...the consultant has already said it wont do anything for PSA.

Take care.

User

Posted 11 Jul 2026 at 21:51

Just to add to focus on when Ra-223 is given and Abiraterone that there is a big risk of skeletal related effects. OH had both, not at the same time and is really suffering from bone fracture pain. He should have been given Zolendronic acid infusion to protect his bone minerality. Good luck and keep asking the questions.

User

Posted 12 Jul 2026 at 09:42

Thanks very much.

My husband is currently only on prostap every 3 months.

He has been on alendronic acid for over a year as he had an insuuficency fracture last year and bone density scan showed osteoporosis.

Due to pain in L5 where cancer is growing he is going to have some targeted radiotherapy which will hopefully help.

Thanks again and take care

User

Posted 12 Jul 2026 at 15:41

Dear Schubert, wishing you continued strength and sending a big hug.

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