Hello everyone,
I wanted to share a brief update on my journey in the hope it might help others looking into advanced staging and early theranostics.
A couple of years ago, I had a highly suspicious PI-RADS 5 lesion on an MRI, but a targeted biopsy came back completely negative. My local doctors told me not to worry, but my PSA kept rising. Trusting the data trend, I pushed for a private 18F-PSMA PET scan. It completely changed my staging, revealing a dominant metastasis in my pelvic bone before the cancer had breached the prostate capsule.
After doing extensive research as a scientist, I chose to look outside standard protocols. I traveled to a specialist theranostics clinic in Germany to receive Lutetium-177 PSMA radioligand therapy early, while my disease was still hormone-sensitive. We also ran a genomic liquid biopsy and found I carry a somatic FANCA mutation, which likely made the cancer highly sensitive to the radiation.
After just two cycles of Lutetium alongside an anti-androgen, my PSA became completely undetectable (<0.01) and my latest follow-up PSMA-PET scans show a complete molecular response—the bone metastasis has completely disappeared. I'm currently dealing with the standard intense fatigue from the hormone blockade, and my oncologist and I are discussing safely de-escalating treatment soon to get my quality of life back.
I'm currently co-authoring a formal medical case report on this protocol with my treating professor in Germany. If anyone is navigating a false-negative biopsy, dealing with hormone-sensitive metastatic disease, or considering traveling for early radioligand therapy, I’d be very glad to share what I've learned about the process.