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Sildenafil v Tadalafil

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User
Posted 18 Jul 2026 at 16:40

I had a unilateral prostatectomy in December last year, and was started on 100mg of Sildenafil 3 times a week in March. I have struggled with the side effects of the Sildenafil- headaches, sore eyes, blurred vision, blocked nose and generally feeling crap for about 24hrs after taking them. I was swapped onto 20mg Tadalafil a few weeks ago, and have been experiencing the same symptoms, albeit not as severely, but they seem to be longer lasting, so I’m not getting any respite from them. I’m also suffering from muscle aches. 

I also don’t feel the Tadalafil is working as effectively as the Sildenafil did for my ED rehab. 

Debating whether to just stick with the Tadalafil for a bit longer as it’s still early days, or to ask to go back onto the Sildenafil or to try something else. I’ve read conflicting info that the side effects should settle down after a few weeks, but also read they can be long term when taking it regularly. 

Has anyone else had this experience and what did you do, or what other medication did you go onto? 

Edited by member 19 Jul 2026 at 10:08  | Reason: Not specified

User
Posted 19 Jul 2026 at 10:49

Hi, Neil.

 I'm a lot older older than you mate, almost seventy.

Not long before my diagnosis I was having ED issues. I dont know if it was linked to my PCa or just an age thing. Anyway, after my diagnosis I was prescribed Sildenafil, I can't rememeber the dosage, but it seemed to help, put a little extra lead in the pencil.

About two years later I had non nerve sparing RARP. The drug then became totally ineffective. That's when the ED clinic put me on Invicorp. Here's a thread on it:

https://community.prostatecanceruk.org/posts/t29845-Hooray-for-Invicorp

I guess you may have already read it. 

All I'm saying mate, if all else fails, give the injections a go. 👍

Edited by member 19 Jul 2026 at 11:08  | Reason: Typo

User
Posted 19 Jul 2026 at 11:09

Hi Adrian thanks for your reply, the ED side of things aren’t my main concern at the moment, but more the side effects of the Tadalafil. I’ve woken up this morning in agony with muscle aches all down my neck, back, glutes and thighs. I know this can be a side effect of the Tadalafil but unsure if they are going to be short term whilst my body adjusts to the new medication, or it’s going to be long term in which case I’ll be asking to go back onto the Sildenafil. 

I’ll have a read of the link you’ve posted. It’s early days for me, was told it could be upto 2 years to see any significant improvement. I was happy with how things were going with the Sildenafil and pump, just noticed a drop off with the Tadalafil but perhaps that’s just an issue with my body needing to adapt to the new meds. 

I’ll admit the thought of injecting myself doesn’t appeal that much 😬😬 and I think I’m a long way off considering it 

 
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