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"Doctor, what happens if my PSA starts to rise after surgery? 😕

User
Posted 21 Jul 2026 at 10:52

I think this is an excellent video, which explains things simply and is worth sharing

https://youtu.be/XwIDxYRp9yE?si=agLYyo6G3UsB4R7M

I was amazed that the Pound study, which monitored 2000 men, who had prostatectomies, revealed that only 15% of them had biochemical recurrence. 

Edited by member 21 Jul 2026 at 13:45  | Reason: Add link

User
Posted 21 Jul 2026 at 10:52

I think this is an excellent video, which explains things simply and is worth sharing

https://youtu.be/XwIDxYRp9yE?si=agLYyo6G3UsB4R7M

I was amazed that the Pound study, which monitored 2000 men, who had prostatectomies, revealed that only 15% of them had biochemical recurrence. 

Edited by member 21 Jul 2026 at 13:45  | Reason: Add link

User
Posted 21 Jul 2026 at 13:17

Adrian

The 15% figure for recurrence among men in the sample sounds too good to be true, but is probably because the median follow-up was only 5 years. To get a more realistic view of the recurrence rate when you have a study with a wide range of follow-up periods, it is better to use an actuarial calculation (sometimes described as something like "Kaplan-Meier") rather than looking at the observed incidence in the sample.

I'm not sure that the long term actuarial rate of recurrence is quoted in the paper because it is mainly concerned with the likelihood of metastasis after recurrence. However, it does reveal that the overall rate of metastasis at 15 years for the whole sample was 18% so the recurrence rate will presumably have been much higher than that.

In general, of course, the recurrence rate observed in any study will depend not just on the follow-up period but also on the characteristics of the men in the sample - e.g. a higher percentage of grade group 1 will generally mean a lower recurrence rate.

Bets wishes

Kevin 

User
Posted 22 Jul 2026 at 18:22

Adrian, I listened to the video,the data was quite old, around 1990s.

Research data always seems to take so long too be published.

Thanks Chris 

 

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User
Posted 21 Jul 2026 at 12:20
Hi Adrian,

Could you provide a link to the Video please? It sounds interesting and I wonder for how long after Prostatectomies they considered because as we know men can have recurrence many years later. A poster on this forum recently confirmed this.

Barry
User
Posted 21 Jul 2026 at 13:17

Adrian

The 15% figure for recurrence among men in the sample sounds too good to be true, but is probably because the median follow-up was only 5 years. To get a more realistic view of the recurrence rate when you have a study with a wide range of follow-up periods, it is better to use an actuarial calculation (sometimes described as something like "Kaplan-Meier") rather than looking at the observed incidence in the sample.

I'm not sure that the long term actuarial rate of recurrence is quoted in the paper because it is mainly concerned with the likelihood of metastasis after recurrence. However, it does reveal that the overall rate of metastasis at 15 years for the whole sample was 18% so the recurrence rate will presumably have been much higher than that.

In general, of course, the recurrence rate observed in any study will depend not just on the follow-up period but also on the characteristics of the men in the sample - e.g. a higher percentage of grade group 1 will generally mean a lower recurrence rate.

Bets wishes

Kevin 

User
Posted 21 Jul 2026 at 14:51

Originally Posted by: Online Community Member

Could you provide a link to the Video please?

Whoops. Silly me. 😳 Link now added Barry.

Kevin, thanks for your clarification. 👍

My 'optimistic bubble' has been well and truly burst. 🙁

Edited by member 21 Jul 2026 at 15:12  | Reason: Additional text

User
Posted 22 Jul 2026 at 18:22

Adrian, I listened to the video,the data was quite old, around 1990s.

Research data always seems to take so long too be published.

Thanks Chris 

 

 
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