Thanks to you both for your replies. I have told him to get an earlier than normal appointment with his diabetic nurse. A big thanks to you Mo for taking the time to reply given your recent loss. I dont post very often but followed your husbands journey with great sympathy. It feels very much to me like series of tick boxes..decapeptyl tick, bicalutamide tick, chemo tick. All the time hoping that the treatment will last a time before failing and onto the next. How I hate this disease.