Ok latest 4 weekly catch up a bit disturbing. Suddenly PSA has jumped from 12 to 19.26. It is either the start of rejection of enzalutimide or an anomaly. Onco checking every avenue. He thinks that my clinical signs remain good so we continue for four weeks. But CT Scan to be done to check there is no disease progression in soft tissues. Also urology tomorrow to see how far the problems there might be interfering with PSA. Unsettling times. Felt a bit down last night but I keep going as always.