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Cabazitaxel Next

User
Posted 22 Mar 2018 at 07:06

AC, Valleyboy,

Keep going guys.

Unfortunately or fortunately (not sure which) I am still on the Doctetaxel bus. The one behind you,

Coming up to infusion 16 and another Chemo break next week.

PSA back down to a more respectable 5.8 and next to no side efffects so can't complain.

As far as canulas go my nurse has found a great spot on the back of my hand to use. Not sure if you you have tried that one.

Warm regards to you both

Dave

"Incurable cancer does not mean it is untreatable and does not mean it is terminal either"
User
Posted 11 Apr 2018 at 18:05

Just had cabazitaxel infusion five. PSA dropped a bit more to 6.1 during the fourth cycle, but that is still a bit above where it was before I started on this regime. CT scan due on 23rd, followed by MDT consideration, possibly before radiologist's report is available. I suppose it is mathematically possible to get close to zero PSA after ten cycles, as although progress is slow on this regime, it does seem to be speeding up. The scan will be revealing. May be followed by a liver biopsy if patch on liver appears to be growing still.

Side effects in fourth cycle much as previously, but because I have this tendency to nausea as a result of my inner ear problem and hiatus hernia, it is a bit difficult to apportion blame! Taste for wine and beer rather dulled by the drugs, which is the really serious side effect. On the other hand, boy, will I appreciate them when I've finished the ten cycles! Half way there now!

AC

User
Posted 11 Apr 2018 at 18:26

Well done A C

I look forward to your postings

 

Barry

User
Posted 11 Apr 2018 at 19:03
Thanks for update AC, you seem to be doing well. The scan will be important as you say.

Best wishes, Ian

Ido4

User
Posted 11 Apr 2018 at 20:04

AC, good news. As Barry I look forward to your updates. Good luck with those scans.

Ray

User
Posted 12 Apr 2018 at 19:01

Slow but sure AC. The nausea is very problematical. Have you asked for Akynzia? Worked wonders for me. One capsule taken an hour before the chemo lasts for 5 days afterwards. 

 

Best regards

User
Posted 13 Apr 2018 at 16:54

Yes, Norman Ingram, I asked my oncologist about this but he said he thought it couldn't be used with cabazitaxel as this chemo is too mild for this drug. NICE guidelines allegedly to blame. Will try again next cycle.

AC

User
Posted 13 Apr 2018 at 20:02

Very strange. Found this http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/003728/human_med_001862.jsp

and this   https://www.nice.org.uk/advice/esnm69/chapter/Key-points-from-the-evidence

 

Cannot see any specific exclusions. All I know it works great. Constipation is a problem but I got that with the standard anti sickness drug anyway. 

Best regards

User
Posted 14 Apr 2018 at 00:52

Fingers crossed for you AC - it is shocking that your beer and wine are being spoilt!

"Life can only be understood backwards; but it must be lived forwards." Soren Kierkegaard

User
Posted 14 Apr 2018 at 18:02

Normaningram, I think I found confirmation of my uncologist's viewpoint in the fine print of your references, for which many thanks. The distinction is between highly emetogenic chemo like cisplatin (which I had for bladder cancer years ago - and it was a hard course, but I was younger then!) and much milder chemo such as cabazitaxel. I'd say from my experience that docetaxel is between the two. So my bloke who plays things by the book has an argument on his side, but he can be persuaded at times and I can be persuasive, so I shall try again next time.

Now, Lyn, both Tigers and City having lost this afternoon, I am definitely going to drink to greater success next week and iit won't be with water.

Cheers

AC

User
Posted 30 Apr 2018 at 17:02

A last update on this thread. My oncologist has taken me off cabazitaxel after five cycles as the primary leasion about which he was concerned (in my liver) has shown significant growth since my last scan in December. So the drug, to coin a phrase "just ain't cutting it". Next step is an urgent biopsy, within days, to find out just what is going on in my liver. Seems unlikely to be prostate cancer. Could it be a recurrence of bladder cancer, last seen five or six years ago? Or something new? Meantime, no more three weekly visits for cabazitaxel but I stay on prednisolone, not that using that alone does anything about PCa, as my experience post-docetaxel showed. Oncologist not bothered about that as my PCa is not life limiting (his comforting words) but what is in my liver might be! I don't know my PSA from today's blood test yet, probably 5.something, but it doesn't matter in the grand scheme of things.

Onward and upward!

AC

User
Posted 30 Apr 2018 at 18:29
Sorry to hear this news AC. You will know more after the biopsy . Your positive attitude as you meet these challenges is inspirational.

Best wishes to you, Ian.

Ido4

User
Posted 30 Apr 2018 at 19:37

One step forward, two back. Best of luck with the biopsy and please carry on being an inspiration to us all.

David

User
Posted 30 Apr 2018 at 21:22

AC, not the news you wanted to hear. Keep being positive though.

Good luck

Ray

User
Posted 30 Apr 2018 at 21:30
AC, great that you are keeping positive at the commencement of the next part of your journey

Regards

Dave

"Incurable cancer does not mean it is untreatable and does not mean it is terminal either"
User
Posted 30 Apr 2018 at 23:09

Oh AC, I am so sorry to see your update. I hope the biopsy is done soon and the results are with you swiftly

"Life can only be understood backwards; but it must be lived forwards." Soren Kierkegaard

 
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