Bose, I cannot console you. With PCa, the only rule is that there are no rules. It is an unpredictable disease. We take medication on the probability that it will work. Sometimes it doesn't. We hope that chemo will prevent the spread of the disease but sometimes it does not. None of us can predict success, merely hope for it. We take the best advice our physicians have to offer. I hope for the best with your Dad's treatment, but as you know, his is an advanced case and you must be ready for setbacks as well as succsses. I hope there will be plenty of the latter.