I'm interested in conversations about and I want to talk about
Know exactly what you want?
Show search

Notification

Error

56 yo recommend treatment complete removal

User
Posted 15 Apr 2024 at 11:46

My cancer hasn't spread beyond the prostate, I have Gleason of 6&7

Hospital recommend complete removal, is there another treatment for me ?

2 reasons, 1 I like to shoot my load. 2. I already suffer with ED following an accident in 2016 the hospital said I'll probably be in the 20% of inactive 

How do you deal with this ?

I'd like to think I have another 20 years to live

User
Posted 15 Apr 2024 at 20:24

Here is my take. The specialists have recommended a course of treatment with curative intent. Many posts on here involve questions about which treatment to have since the specialists often don't recommend one over the other since they result in similar outcomes and life expectancy. Except in my case, like yourself, I was given a good nudge towards surgery because the consultants thought that would provide the best long term outcome. However I am surprised that they have not offered you the chance to talk to the oncologist about RT so you can properly weigh up your options.

User
Posted 03 May 2024 at 10:16

My father and neighbour have prostate cancer as well so I made a list of what I could find online.

-----------------------------------------
Alternative treatments
-----------------------------------------

    Altogether, our results indicate that the activation of the
    TRPV1/LKB1/AMPK pathway by capsaicin results in a significant
    decrease in cell proliferation, suggesting that TRPV1-targeted
    pharmaceutical interventions may be exploited to suppress the
    growth of prostate tumors.

The Natural Chemotherapeutic Capsaicin Activates AMPK through
LKB1 Kinase and TRPV1 Receptors in Prostate Cancer Cells - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880011/

A 15 Year Evolution of Dichloroacetate-Based Metabolic Cancer
Therapy: A Review with Case Reports | Medical Research Archives
https://esmed.org/MRA/mra/article/view/4118

Inhibitors of the PI3K/Akt/mTOR Pathway in Prostate Cancer
Chemoprevention and Intervention - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400324/

What is cryotherapy for prostate cancer?
https://urologysingapore.com/what-is-cryotherapy-for-prostate-cancer/

Treatment with abiraterone significantly improves survival in advanced prostate cancer - Harvard Health
https://www.health.harvard.edu/blog/treatment-with-abiraterone-significantly-improves-survival-in-advanced-prostate-cancer-202201282678

Antiproliferative effect on human prostate cancer cells by a stinging nettle root (Urtica dioica) extract - PubMed
https://pubmed.ncbi.nlm.nih.gov/10705733/

Stinging nettles: A new approach to cancer
https://www.medicalnewstoday.com/articles/320573

What exactly are saw palmetto and stinging nettle? - Chiropractic Economics
https://www.chiroeco.com/saw-palmetto-for-prostate-cancer/

Cancer targeted with reusable 'stinging nettle' treatment -- ScienceDaily
https://www.sciencedaily.com/releases/2018/01/180109112429.htm

Frontiers | Hydrogen Gas in Cancer Treatment | Oncology
https://www.frontiersin.org/articles/10.3389/fonc.2019.00696/full

The Yin Yang Role of Nitric Oxide in Prostate Cancer - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008561/

Arginine deprivation: a potential therapeutic for cancer cell metastasis? A review | Cancer Cell International | Full Text
https://cancerci.biomedcentral.com/articles/10.1186/s12935-020-01232-9

A patient's story: Why one man opted for lifestyle changes instead of treatment - Harvard Health
https://www.health.harvard.edu/blog/a-patients-story-why-one-man-opted-for-lifestyle-changes-instead-of-treatment-2009111012

Science Talk - "My treatment has given me a new lease of life" - Rob's prostate cancer story - The Institute of Cancer Research, London
https://www.icr.ac.uk/blogs/science-talk/page-details/my-treatment-has-given-me-a-new-lease-of-life-rob-s-prostate-cancer-story

Androgen Deprivation Therapy for Recurrent Prostate Cancer - National Cancer Institute
https://www.cancer.gov/news-events/cancer-currents-blog/2017/androgen-deprivation-therapy-prostate

Nettle - Western New York Urology Associates, LLC
https://www.wnyurology.com/content.aspx?chunkiid=21815

A Possible Association between Melanoma and Prostate Cancer. Results from a Case-Control-Study - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491677/

prostate cancer | Health Topics | NutritionFacts.org
https://nutritionfacts.org/topics/prostate-cancer/

Treating Advanced Prostate Cancer with Diet: Part 1 | NutritionFacts.org
https://nutritionfacts.org/video/treating-advanced-prostate-cancer-with-diet-part-1/

Treating Advanced Prostate Cancer with Diet: Part 2 | NutritionFacts.org
https://nutritionfacts.org/video/treating-advanced-prostate-cancer-with-diet-part-2/

Natural Prostate Cancer Treatment
https://www.earthclinic.com/cures/prostate-cancer.html

(PDF) High dietary acid load is associated with prostate cancer
risk: an epidemiological study
https://www.researchgate.net/publication/356579292_High_dietary_acid_load_is_associated_with_prostate_cancer_risk_an_epidemiological_study

    Consumption of a net acid-producing diet can produce “acid
    stress” detrimental to human health [1,2]. Progressive acid
    accumulation subsequent to a high intake of acid precursors and
    impaired buffer mechanisms can alter the systemic acid–base
    balance [3,4]. Chronic low-grade acid accumulation has been
    associated with cardiometabolic diseases [5,6,7], renal disorders
    [8,9,10], and various cancer types [11,12,13,14].

How Well Do Low-PRAL Diets Fare in Comparison to the 2020–2025
Dietary Guidelines for Americans? - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9859335/


    Vitamin D exhibits diverse antineoplastic activity through
    various pathways. It binds to the vitamin D receptor and induces
    differentiation and apoptosis; it also inhibits cancer stem
    cells, proliferation, angiogenesis, and metastatic potential
    [332].

    DSF [Disulfiram] may be beneficial in treating breast, lung, pancreatic,
    prostate, liver, and ovarian cancer, as well as acute myeloid
    leukemia, glioblastoma, and melanoma, with a particular role
    in glioblastoma patients [124,454]. The recommended dosing
    for DSF is generally 80 mg three times a day or 500 mg once
    daily, and copper should be added at a dose of 2 mg three
    times a day [128,129].

Cancer Metabolism as a Therapeutic Target and Review of
Interventions - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10574675/


    Magnesium is an essential cofactor for vitamin D synthesis, and
    activated vitamin D, in turn, can increase intestinal absorption
    of magnesium and, therefore, can form a feed-forward loop to
    maintain its homeostasis.
     
Role of Magnesium in Vitamin D Activation and Function
https://www.degruyter.com/document/doi/10.7556/jaoa.2018.037/html?lang=en

Vitamin D and Magnesium - Life Extension
https://www.lifeextension.com/magazine/2021/7/vitamin-d-magnesium-connection

Calcium, Phosphorus, and Magnesium Metabolism | Obgyn Key
https://obgynkey.com/calcium-phosphorus-and-magnesium-metabolism/

    When prostate cancer cells in culture are treated with vitamin
    K2, both those sensitive to male hormones (androgens) and those
    resistant to male hormones are unable to reproduce, and
    eventually die.47 Vitamin K2 has been associated with a 63% lower
    risk of advanced prostate cancer in men with the highest intake
    of the nutrient.7 Similarly, a higher ratio of vitamin
    K-activated osteocalcin versus inactive osteocalcin correlates
    closely with reduced prostate cancer risk, demonstrating the
    molecular connection.48

Does Vitamin K Help You Slow The Aging? - Life Extension
https://www.lifeextension.com/magazine/2014/9/the-surprising-longevity-benefits-of-vitamin-k


    Chi et al. [67] found a relationship between increased
    concentrations of ketosis-related compounds and prostate specific
    antigen (PSA) double time, indicating that cancer growth was
    reduced in a ketosis-intensified diet (CAPS2 diet trial).
    Because current evidence supports a plant-based diet as part of a
    healthy lifestyle associated with reduced cancer risk [68], how
    do we reconcile a plant-based with ketogenic diet when it
    concerns cancer prevention and/or management? Perhaps it will
    take a randomized trial comparing a plant-based vs. fat-based
    diet to prove which is better for patients with prostate and
    other cancers.
    It is of interest that several natural compounds produced during
    ketosis, such as beta-hydroxybutyrate, a short-chain fatty acid
    with documented antioxidant and anti-inflammatory effects, may
    affect the microbiome in a favorable manner and provide
    salubrious as well as anti-cancer effects.
    For example, Cheng et al. [69] reported that both fasting and a
    high-fat diet improve the function of intestinal stem cells. They
    published that any kind of diet in which carbohydrate intake is
    limited stimulates ketogenesis and promotes the growth of
    intestinal stem cells.
    What remains unclear is that if fasting or a ketogenic diet
    enables healing and proliferation of intestinal NSCs, would it
    paradoxically empower CSCs, too? Perhaps, ketogenesis and fasting
    are good for prevention of cancer, but not so good when a patient
    already has active, if not fulminant, cancer.

    ...

    If we hypothesize that cancer is a metabolic disease and
    glucose is central to cancer metabolism, then we give DCA and
    2DG and we take aspartame and ketogenic diet. We have learned
    and will discover that what is effective in treating cancer
    cells in the laboratories may be futile and could even be
    harmful to patients in the clinics [34].
    If we hypothesize that cancer is a stem-cell rather than
    genetic or metabolic disease, then we need to consider
    genetic content and metabolic activity in the proper cellular
    context. We need to account for glycolysis and OXOPHOS, as
    well as glucose, glutamine, arginine, and other metabolic
    substrates and cancer metabolites in the right metabolic
    perspective and narrative (Table 2). We need to treat both
    CSCs, non-CSCs, and the onco-niche.

Cancers | Free Full-Text | Stem Cell Theory of Cancer: Clinical
Implications for Cellular Metabolism and Anti-Cancer Metabolomics
https://www.mdpi.com/2072-6694/16/3/624


    In conclusion, two processes are important for cancer initiation
    and subsequent development: mutations in nuclear DNA induced by
    free radical oxidative damage and inflammation. Given the
    antioxidant and anti-inflammatory action of CoQ10, the latter
    would be expected to protect against cancer initiation. There is
    support for this scenario where reduced levels of CoQ10 have been
    identified as a risk factor for the development of several types
    of cancer, as noted above.

Oxygen | Free Full-Text | Energy Metabolism as a Therapeutic
Target in Cancer: The Role of Coenzyme Q10
https://www.mdpi.com/2673-9801/4/2/8


-----------------------------------------
Gut bacteria
-----------------------------------------

Microbiomes of Urine and the Prostate Are Linked to Human
Prostate Cancer Risk Groups - ScienceDirect
https://www.sciencedirect.com/science/article/abs/pii/S2588931122000566

Bacilac Femina Capsules 30st kopen bij De Online Drogist
https://www.deonlinedrogist.nl/drogist/bacilac-femina-capsules-30st.htm

Effects of potential synbiotic interaction between Lactobacillus
rhamnosus GG and salicylic acid on human colon and prostate
cancer cells - PubMed
https://pubmed.ncbi.nlm.nih.gov/33620523/

An Update on the Effectiveness of Probiotics in the Prevention
and Treatment of Cancer - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779143/

Potential role of gastrointestinal microbiota composition in
prostate cancer risk - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826836/

Compositional differences in gastrointestinal microbiota in
prostate cancer patients treated with androgen axis-targeted
therapies - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283851/

What’s New in Inflammation and Prostate Cancer | Prostate Cancer
Foundation
https://www.pcf.org/c/whats-new-in-inflammation-and-prostate-cancer/


    Better known as a nasty gastrointestinal bug, E. coli causes
    inflammation in the urinary tract and is a known cause of
    bacterial prostatitis.
    As the scientists discovered, colibactin, a genotoxin produced by
    some strains of E. coli, can also instigate a series of
    unfortunate events in the prostate. Bacterial infection leads to
    acute and chronic inflammation, which can lead to the development
    of a lesion in the prostate called proliferative inflammatory
    atrophy (PIA), first described by De Marzo, William (Bill)
    Nelson, M.D., Ph.D., and other Brady scientists; it can also
    cause DNA damage. The presence of colibactin is even more
    ominous, because it can directly lead to double-stranded DNA
    breakage.

    Sfanos suspects that this combination leads, in turn, to another
    development: fusion of two genes, TMPRSS2 and ERG, that normally
    should remain separate, but in this case get abnormally spliced
    together. This TMPRSS2/ERG fusion – found in as many as half of
    all prostate cancers – is thought to be an early event leading to
    the development of prostate cancer.

Infection, Inflammation, and Prostate Cancer: “Smoking Gun”
Evidence! | Johns Hopkins Medicine
https://www.hopkinsmedicine.org/news/articles/2020/11/infection-inflammation-and-prostate-cancer-smoking-gun-evidence


    Continuous proliferation of the aforementioned pathogenic
    bacteria might eventually change or outcompete natural
    microbiome of the prostatic tissue. This may lead to chronic
    inflammation and immune imbalance. When stimulated by
    bacterial components, phagocytes (mainly macrophages) release
    reactive oxygen species and reactive nitrogen species. These
    factors may directly damage DNA and cause genetic instability
    [11]. Thus, induced oxidative stress and the consequent
    cellular damage can stimulate proliferation of atrophic
    luminal epithelial cells, creating regions known as
    proliferative inflammatory atrophy (PIA), i.e., precursors of
    prostate malignancies [25].

The Role of Microbial Factors in Prostate Cancer Development—An
Up-to-Date Review - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538262/


Case report: Successful treatment of recurrent E. coli infection
with bacteriophage therapy for patient suffering from chronic
bacterial prostatitis - PubMed
https://pubmed.ncbi.nlm.nih.gov/37790805/


-----------------------------------------
Bill Munro - Hydrogen peroxide inhalation
-----------------------------------------

How to inhale Hydrogen Peroxide for Good Health This is a video
of 83 Year Old Bill Munro demonstrating how he inhales Hydrogen
Peroxide. For legal protection against lawsuits, etc. he also
recommends that...
https://www.youtube.com/watch?v=aT1_Rkl0B1M


A Natural Cure for Viral Infections and Cancer –
SetantaHypnotherapyClinic
https://setantahypnotherapy.com/a-natural-cure-for-viral-infections-and-cancer/

Hydrogen_Peroxide
https://web.archive.org/web/20040612084159/http://landrights.com/Hydrogen_Peroxide.htm

A Natural Cure for Viral Infections and Cancer - SetantaHypnotherapyClinic
https://setantahypnotherapy.com/a-natural-cure-for-viral-infections-and-cancer

Prostate Cancer
https://pcri.org/royal-1/2017/9/19/j8qay87k0sft1qoz7p1cc0m9otstru-fwwzb

Hydrogen peroxide fuels aging, inflammation, cancer metabolism and metastasis - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180186/

Oxidants Are Not All Created Equal | Could Hydrogen Peroxide Actually Be Good for Our Lungs? | American Journal of Respiratory and Critical Care Medicine
https://www.atsjournals.org/doi/full/10.1164/rccm.200902-0224ED

33% hydrogen peroxide as a Neoadjuvant treatment in the surgical excision of non-melanoma skin cancers: a case series | Journal of Otolaryngology - Head & Neck Surgery | Full Text
https://journalotohns.biomedcentral.com/articles/10.1186/s40463-020-00433-6

Hydrogen peroxide cancer treatment: Warnings, claims, and research
https://www.medicalnewstoday.com/articles/323591#takeaway

Hydrogen Peroxide Inhalation Method
http://arizonaenergy.org/News_10/News_Aug10/Hydrogen%20Peroxide%20Inhalation%20Method.htm

Alternatives in Cancer Therapy - Hydrogen Peroxide
http://educate-yourself.org/cn/hydrogenperoxidecancertherapybookexcerpt.shtml

Hydrogen Peroxide v. Prostate Cancer
http://educate-yourself.org/cn/hydrogenperoxideandprostatecancer14oct05.shtml

    Research has explored how high doses of vitamin C can produce
    hydrogen peroxide, a substance that can kill cancer cells. Unlike
    cancer cells, normal cells have the ability to break down
    hydrogen peroxide and prevent it from causing damage. This
    selective toxicity makes high-dose vitamin C an intriguing
    complementary approach in cancer care.

High Dose Vitamin C IV Drip London
https://integratedmedicine.co/complementary-cancer-care/iv-drips/iv-infusions-menu/high-dose-vitamin-c-iv-drip/

    Additionally, in all the cases high dose IV vitamin C also
    prolonged the lives of these cancer patients. Using this
    rationale, we also treated our patient with high dose IV vitamin
    C for prostate cancer and had a positive outcome.
    ...
    At normal physiologic concentrations, vitamin C acts as an
    antioxidant that inactivates reactive oxygen species. However at
    high pharmacologic concentrations vitamin C acts a pro-oxidant by
    generating oxidative species such extracellular hydrogen peroxide
    [13,14]. This hydrogen peroxide generated is delivered to tissues
    but not found in the blood [9]. Several in vitro studies have
    shown that the extracellular vitamin C, that generates hydrogen
    peroxide, kills away the cancer cells selectively but does not
    harm the normal cells [13]. This vitamin C mediated cancer cell
    death, is only obtained when vitamin C is administered
    intravenously.

    The mechanism of action of vitamin C is intricate, yet deadly to
    the cancer cells. Extracellular hydrogen peroxide from high doses
    of vitamin C diffuses into the cancer cells and causes toxicity
    in these cells by ATP depletion which eventually leads to cell
    death [16]. Additionally, hydrogen peroxide toxicity compromises
    membrane glucose metabolism and DNA integrity in the cancer cells
    [16]. In the normal cells hydrogen peroxide is readily
    neutralized by antioxidant enzymes such as catalase, glutathione
    peroxidase and superoxide dismutase. The level of these enzymes
    in cancer cells is low which causes the toxicity and cancer cell
    death [15].

    Additionally, the patient also took the Salerno Abe Factors
    which contains Green Tea Leaf extract, L-Carnosine,
    Quercetin, Alpha Lipoic Acid, Resveratrol and Benfotiamine,
    the highest available concentrations in the world. All the
    nutrients mentioned here have powerful antioxidant
    capabilities. Additionally, studies have shown that Quercetin
    exerts a direct, pro-apoptotic effect in tumor cells and
    blocks the growth of several human cell lines at different
    phases of the cell cycle [17].

    Emerging evidence now shows that concentrations of vitamin C at a
    concentration of 1000e5000 mmol/L are selectively toxic to cancer
    cells [9]. This concentration is achieved only through
    intravenous administration of vitamin C. In the case report
    presented above, using high dose IV vitamin C, we were able to
    show that the vascular area in the prostate gland disappeared
    after about 10 months of treatment. These data confer some
    validation that vitamin C can offer anti-tumor effects and
    further studies are warranted to learn its complete role.

High dose IV vitamin C for treatment of prostate adenocarcinoma - ScienceDirect
https://www.sciencedirect.com/science/article/abs/pii/S2186495013000023

60 Minutes New Zealand, Alan Smith Cured by Intravenous Vitamin C
https://www.bitchute.com/video/FFaBJrNT5Nqk/

Amazon.com: LivOn Laboratories Lypo–Spheric Vitamin C – 30
Packets – 1,000 mg Vitamin C & 1,000 mg Essential Phospholipids
Per Packet – Liposome Encapsulated for Improved Absorption – 100%
Non–GMO : Health & Household
https://www.amazon.com/Lypo-Spheric-Vitamin-Bioavailability-Professionally-Phospholipids/dp/B000CD9XGC?th=1

Can too much Vitamin C and D be a bad thing? - Urologist Singapore | Urohealth Medical Clinic
https://us14.proxysite.com/process.php?d=86yiZy5n5prZA4kUnOE67OUowm7BokJefZCqmBD6ZIrerj2zMu0XudeJyc7v6LLlNe0CNpg5sNqXMNk7ouAc4IatAIll&b=1



--------------------------------------------------------------------------------
Faith
--------------------------------------------------------------------------------

Mark Manson healed from prostate cancer - Riverlife
https://riverlifechurch.org.au/story/mark/


Bernard | Suffering from prostate cancer, I choose to let Jesus
heal me | MyStory.me
https://mystory-me.translate.goog/story/btuch/?_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=en-US&_x_tr_pto=wapp


My Journey with Prostate Cancer and what I believe to be God
incidents. - Personal stories - Prostate Cancer UK Online
Community
https://community.prostatecanceruk.org/posts/t10819-My-Journey-with-Prostate-Cancer-and-what-I-believe-to-be-God-incidents

 

Edited by member 03 May 2024 at 10:36  | Reason: Not specified

User
Posted 15 Apr 2024 at 12:24
Either way, I think "Load shooting" will be a thing of the past will be the reality I'm afraid.

Better than the alternative - Eh?

User
Posted 04 May 2024 at 14:41
We know that treatments of various kinds have improved greatly over the last ten years or so for men that have PCa but how much better it would be if it could be definitely established through trials that the incidence of PCa could be reduced in the first place, ideally by natural choice, injection or supplements. Unfortunately, there is no incentive for big Pharma who fund research for their expensive drugs to do so for anything that could potentially obviate or reduce the need for such high cost medication.

I remember when I was first diagnosed with PCa back in 2007 I did a lot of research on potential treatments and in doing do came upon somebody in the USA who treated his patients with high doses of injected Vitamin 'C', with good results but he was prosecuted to the point that he was forced to stop. (I believe one of the references alludes to intravenous injection of high doses of vitamin 'C'. I have not read the link but assume this equates with what I read). But essentially this was a form of treatment rather than something to stop PCa developing in the first place. The only way I can see of making progress in halting the development of PCa is for Government to fund trials. It took Government pressure to introduce measures to reduce cigarette smoking and thereby reduce the incidence of Lung Cancer and other medical issues, notwithstanding the loss of revenue generated on sales of tobacco. This was done against a background of obfuscation and delaying tactics by the tobacco industry.

Barry
Show Most Thanked Posts
User
Posted 15 Apr 2024 at 12:24
Either way, I think "Load shooting" will be a thing of the past will be the reality I'm afraid.

Better than the alternative - Eh?

User
Posted 15 Apr 2024 at 13:26

That aside, is there other treatments ?

If not how have people dealt with being inactive?

User
Posted 15 Apr 2024 at 13:41

Have they discussed radiation ?

either way there will be nothing to shoot but with radiation you still get a orgasmic feeling and can still get it up. The question is if its contained and they remove it will you mentally be happy that its unlikely to cause you problems later or do you want to take a chance and still have some sexual function?

 

User
Posted 15 Apr 2024 at 14:19

Don't (or DIDN'T WE) we all. 😁

But as my parents used to tell me as a kid, "He who wants never gets"

I'm mystified why you have two Gleason scores?

 

 

User
Posted 15 Apr 2024 at 14:26
I have 3+4 one side and 4+3 the other so I suppose he could have 3+3 and a 3+4 ?
User
Posted 15 Apr 2024 at 15:21

Exactly 

I have 3 cores with 3+4

And

2 cores with 3+3

 

Edited by member 15 Apr 2024 at 15:23  | Reason: Not specified

User
Posted 15 Apr 2024 at 15:32

Originally Posted by: Online Community Member

Have they discussed radiation ?

either way there will be nothing to shoot but with radiation you still get a orgasmic feeling and can still get it up. The question is if its contained and they remove it will you mentally be happy that its unlikely to cause you problems later or do you want to take a chance and still have some sexual function?

 

RT is the best option, by far in most cases - there will always be risks - but with death as the big option, you must face it.

User
Posted 15 Apr 2024 at 16:21

You could ask about focal therapies. They treat just the cancer and not the whole prostate. It depends if your cancer is focal and where it is as to how suitable you might be. You need to be referred to a focal therapy centre to find out if you're suitable.

Pros:
Generally fewer side effects. Depending where the cancer is, you might preserve erectile function, continence, and even some semen.

Cons:
Might not treat all the cancer (usually only one or two main lesions are treated), leaving you on active surveillance for what's left.
More likely to recur. Prostate cancer often isn't focal, springing up in many places in the prostate eventually. Can sometimes be treated with focal again, but also radiotherapy or prostatectomy are likely to be salvage options too. You might end up worse off after either of these salvage treatments than if you'd had them in the first place though.
There might be a slightly higher possibility of it recurring and eventually going metastatic than if you have a whole-prostate treatment at the outset.
Not many centres do focal therapies, and they're mostly in the South-East, so it might involve some travel.

A pre-existing reduction in erectile function doesn't help with outcomes of erectile function - it's not going to improve and often gets at least a little worse. Have you have that investigated and is the cause known?

EDIT: Just to add, preserving some semen is not the same as remaining fertile, if that's the reason for concern. Semen contains lots of different components, and although you might still ejaculate something, which if you're lucky still looks like semen, it doesn't mean all the components will still be present, so it is much less likely to be viable for fertility even so.

Edited by member 15 Apr 2024 at 16:27  | Reason: Not specified

User
Posted 15 Apr 2024 at 20:24

Here is my take. The specialists have recommended a course of treatment with curative intent. Many posts on here involve questions about which treatment to have since the specialists often don't recommend one over the other since they result in similar outcomes and life expectancy. Except in my case, like yourself, I was given a good nudge towards surgery because the consultants thought that would provide the best long term outcome. However I am surprised that they have not offered you the chance to talk to the oncologist about RT so you can properly weigh up your options.

User
Posted 03 May 2024 at 10:16

My father and neighbour have prostate cancer as well so I made a list of what I could find online.

-----------------------------------------
Alternative treatments
-----------------------------------------

    Altogether, our results indicate that the activation of the
    TRPV1/LKB1/AMPK pathway by capsaicin results in a significant
    decrease in cell proliferation, suggesting that TRPV1-targeted
    pharmaceutical interventions may be exploited to suppress the
    growth of prostate tumors.

The Natural Chemotherapeutic Capsaicin Activates AMPK through
LKB1 Kinase and TRPV1 Receptors in Prostate Cancer Cells - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880011/

A 15 Year Evolution of Dichloroacetate-Based Metabolic Cancer
Therapy: A Review with Case Reports | Medical Research Archives
https://esmed.org/MRA/mra/article/view/4118

Inhibitors of the PI3K/Akt/mTOR Pathway in Prostate Cancer
Chemoprevention and Intervention - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400324/

What is cryotherapy for prostate cancer?
https://urologysingapore.com/what-is-cryotherapy-for-prostate-cancer/

Treatment with abiraterone significantly improves survival in advanced prostate cancer - Harvard Health
https://www.health.harvard.edu/blog/treatment-with-abiraterone-significantly-improves-survival-in-advanced-prostate-cancer-202201282678

Antiproliferative effect on human prostate cancer cells by a stinging nettle root (Urtica dioica) extract - PubMed
https://pubmed.ncbi.nlm.nih.gov/10705733/

Stinging nettles: A new approach to cancer
https://www.medicalnewstoday.com/articles/320573

What exactly are saw palmetto and stinging nettle? - Chiropractic Economics
https://www.chiroeco.com/saw-palmetto-for-prostate-cancer/

Cancer targeted with reusable 'stinging nettle' treatment -- ScienceDaily
https://www.sciencedaily.com/releases/2018/01/180109112429.htm

Frontiers | Hydrogen Gas in Cancer Treatment | Oncology
https://www.frontiersin.org/articles/10.3389/fonc.2019.00696/full

The Yin Yang Role of Nitric Oxide in Prostate Cancer - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008561/

Arginine deprivation: a potential therapeutic for cancer cell metastasis? A review | Cancer Cell International | Full Text
https://cancerci.biomedcentral.com/articles/10.1186/s12935-020-01232-9

A patient's story: Why one man opted for lifestyle changes instead of treatment - Harvard Health
https://www.health.harvard.edu/blog/a-patients-story-why-one-man-opted-for-lifestyle-changes-instead-of-treatment-2009111012

Science Talk - "My treatment has given me a new lease of life" - Rob's prostate cancer story - The Institute of Cancer Research, London
https://www.icr.ac.uk/blogs/science-talk/page-details/my-treatment-has-given-me-a-new-lease-of-life-rob-s-prostate-cancer-story

Androgen Deprivation Therapy for Recurrent Prostate Cancer - National Cancer Institute
https://www.cancer.gov/news-events/cancer-currents-blog/2017/androgen-deprivation-therapy-prostate

Nettle - Western New York Urology Associates, LLC
https://www.wnyurology.com/content.aspx?chunkiid=21815

A Possible Association between Melanoma and Prostate Cancer. Results from a Case-Control-Study - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491677/

prostate cancer | Health Topics | NutritionFacts.org
https://nutritionfacts.org/topics/prostate-cancer/

Treating Advanced Prostate Cancer with Diet: Part 1 | NutritionFacts.org
https://nutritionfacts.org/video/treating-advanced-prostate-cancer-with-diet-part-1/

Treating Advanced Prostate Cancer with Diet: Part 2 | NutritionFacts.org
https://nutritionfacts.org/video/treating-advanced-prostate-cancer-with-diet-part-2/

Natural Prostate Cancer Treatment
https://www.earthclinic.com/cures/prostate-cancer.html

(PDF) High dietary acid load is associated with prostate cancer
risk: an epidemiological study
https://www.researchgate.net/publication/356579292_High_dietary_acid_load_is_associated_with_prostate_cancer_risk_an_epidemiological_study

    Consumption of a net acid-producing diet can produce “acid
    stress” detrimental to human health [1,2]. Progressive acid
    accumulation subsequent to a high intake of acid precursors and
    impaired buffer mechanisms can alter the systemic acid–base
    balance [3,4]. Chronic low-grade acid accumulation has been
    associated with cardiometabolic diseases [5,6,7], renal disorders
    [8,9,10], and various cancer types [11,12,13,14].

How Well Do Low-PRAL Diets Fare in Comparison to the 2020–2025
Dietary Guidelines for Americans? - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9859335/


    Vitamin D exhibits diverse antineoplastic activity through
    various pathways. It binds to the vitamin D receptor and induces
    differentiation and apoptosis; it also inhibits cancer stem
    cells, proliferation, angiogenesis, and metastatic potential
    [332].

    DSF [Disulfiram] may be beneficial in treating breast, lung, pancreatic,
    prostate, liver, and ovarian cancer, as well as acute myeloid
    leukemia, glioblastoma, and melanoma, with a particular role
    in glioblastoma patients [124,454]. The recommended dosing
    for DSF is generally 80 mg three times a day or 500 mg once
    daily, and copper should be added at a dose of 2 mg three
    times a day [128,129].

Cancer Metabolism as a Therapeutic Target and Review of
Interventions - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10574675/


    Magnesium is an essential cofactor for vitamin D synthesis, and
    activated vitamin D, in turn, can increase intestinal absorption
    of magnesium and, therefore, can form a feed-forward loop to
    maintain its homeostasis.
     
Role of Magnesium in Vitamin D Activation and Function
https://www.degruyter.com/document/doi/10.7556/jaoa.2018.037/html?lang=en

Vitamin D and Magnesium - Life Extension
https://www.lifeextension.com/magazine/2021/7/vitamin-d-magnesium-connection

Calcium, Phosphorus, and Magnesium Metabolism | Obgyn Key
https://obgynkey.com/calcium-phosphorus-and-magnesium-metabolism/

    When prostate cancer cells in culture are treated with vitamin
    K2, both those sensitive to male hormones (androgens) and those
    resistant to male hormones are unable to reproduce, and
    eventually die.47 Vitamin K2 has been associated with a 63% lower
    risk of advanced prostate cancer in men with the highest intake
    of the nutrient.7 Similarly, a higher ratio of vitamin
    K-activated osteocalcin versus inactive osteocalcin correlates
    closely with reduced prostate cancer risk, demonstrating the
    molecular connection.48

Does Vitamin K Help You Slow The Aging? - Life Extension
https://www.lifeextension.com/magazine/2014/9/the-surprising-longevity-benefits-of-vitamin-k


    Chi et al. [67] found a relationship between increased
    concentrations of ketosis-related compounds and prostate specific
    antigen (PSA) double time, indicating that cancer growth was
    reduced in a ketosis-intensified diet (CAPS2 diet trial).
    Because current evidence supports a plant-based diet as part of a
    healthy lifestyle associated with reduced cancer risk [68], how
    do we reconcile a plant-based with ketogenic diet when it
    concerns cancer prevention and/or management? Perhaps it will
    take a randomized trial comparing a plant-based vs. fat-based
    diet to prove which is better for patients with prostate and
    other cancers.
    It is of interest that several natural compounds produced during
    ketosis, such as beta-hydroxybutyrate, a short-chain fatty acid
    with documented antioxidant and anti-inflammatory effects, may
    affect the microbiome in a favorable manner and provide
    salubrious as well as anti-cancer effects.
    For example, Cheng et al. [69] reported that both fasting and a
    high-fat diet improve the function of intestinal stem cells. They
    published that any kind of diet in which carbohydrate intake is
    limited stimulates ketogenesis and promotes the growth of
    intestinal stem cells.
    What remains unclear is that if fasting or a ketogenic diet
    enables healing and proliferation of intestinal NSCs, would it
    paradoxically empower CSCs, too? Perhaps, ketogenesis and fasting
    are good for prevention of cancer, but not so good when a patient
    already has active, if not fulminant, cancer.

    ...

    If we hypothesize that cancer is a metabolic disease and
    glucose is central to cancer metabolism, then we give DCA and
    2DG and we take aspartame and ketogenic diet. We have learned
    and will discover that what is effective in treating cancer
    cells in the laboratories may be futile and could even be
    harmful to patients in the clinics [34].
    If we hypothesize that cancer is a stem-cell rather than
    genetic or metabolic disease, then we need to consider
    genetic content and metabolic activity in the proper cellular
    context. We need to account for glycolysis and OXOPHOS, as
    well as glucose, glutamine, arginine, and other metabolic
    substrates and cancer metabolites in the right metabolic
    perspective and narrative (Table 2). We need to treat both
    CSCs, non-CSCs, and the onco-niche.

Cancers | Free Full-Text | Stem Cell Theory of Cancer: Clinical
Implications for Cellular Metabolism and Anti-Cancer Metabolomics
https://www.mdpi.com/2072-6694/16/3/624


    In conclusion, two processes are important for cancer initiation
    and subsequent development: mutations in nuclear DNA induced by
    free radical oxidative damage and inflammation. Given the
    antioxidant and anti-inflammatory action of CoQ10, the latter
    would be expected to protect against cancer initiation. There is
    support for this scenario where reduced levels of CoQ10 have been
    identified as a risk factor for the development of several types
    of cancer, as noted above.

Oxygen | Free Full-Text | Energy Metabolism as a Therapeutic
Target in Cancer: The Role of Coenzyme Q10
https://www.mdpi.com/2673-9801/4/2/8


-----------------------------------------
Gut bacteria
-----------------------------------------

Microbiomes of Urine and the Prostate Are Linked to Human
Prostate Cancer Risk Groups - ScienceDirect
https://www.sciencedirect.com/science/article/abs/pii/S2588931122000566

Bacilac Femina Capsules 30st kopen bij De Online Drogist
https://www.deonlinedrogist.nl/drogist/bacilac-femina-capsules-30st.htm

Effects of potential synbiotic interaction between Lactobacillus
rhamnosus GG and salicylic acid on human colon and prostate
cancer cells - PubMed
https://pubmed.ncbi.nlm.nih.gov/33620523/

An Update on the Effectiveness of Probiotics in the Prevention
and Treatment of Cancer - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779143/

Potential role of gastrointestinal microbiota composition in
prostate cancer risk - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826836/

Compositional differences in gastrointestinal microbiota in
prostate cancer patients treated with androgen axis-targeted
therapies - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283851/

What’s New in Inflammation and Prostate Cancer | Prostate Cancer
Foundation
https://www.pcf.org/c/whats-new-in-inflammation-and-prostate-cancer/


    Better known as a nasty gastrointestinal bug, E. coli causes
    inflammation in the urinary tract and is a known cause of
    bacterial prostatitis.
    As the scientists discovered, colibactin, a genotoxin produced by
    some strains of E. coli, can also instigate a series of
    unfortunate events in the prostate. Bacterial infection leads to
    acute and chronic inflammation, which can lead to the development
    of a lesion in the prostate called proliferative inflammatory
    atrophy (PIA), first described by De Marzo, William (Bill)
    Nelson, M.D., Ph.D., and other Brady scientists; it can also
    cause DNA damage. The presence of colibactin is even more
    ominous, because it can directly lead to double-stranded DNA
    breakage.

    Sfanos suspects that this combination leads, in turn, to another
    development: fusion of two genes, TMPRSS2 and ERG, that normally
    should remain separate, but in this case get abnormally spliced
    together. This TMPRSS2/ERG fusion – found in as many as half of
    all prostate cancers – is thought to be an early event leading to
    the development of prostate cancer.

Infection, Inflammation, and Prostate Cancer: “Smoking Gun”
Evidence! | Johns Hopkins Medicine
https://www.hopkinsmedicine.org/news/articles/2020/11/infection-inflammation-and-prostate-cancer-smoking-gun-evidence


    Continuous proliferation of the aforementioned pathogenic
    bacteria might eventually change or outcompete natural
    microbiome of the prostatic tissue. This may lead to chronic
    inflammation and immune imbalance. When stimulated by
    bacterial components, phagocytes (mainly macrophages) release
    reactive oxygen species and reactive nitrogen species. These
    factors may directly damage DNA and cause genetic instability
    [11]. Thus, induced oxidative stress and the consequent
    cellular damage can stimulate proliferation of atrophic
    luminal epithelial cells, creating regions known as
    proliferative inflammatory atrophy (PIA), i.e., precursors of
    prostate malignancies [25].

The Role of Microbial Factors in Prostate Cancer Development—An
Up-to-Date Review - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538262/


Case report: Successful treatment of recurrent E. coli infection
with bacteriophage therapy for patient suffering from chronic
bacterial prostatitis - PubMed
https://pubmed.ncbi.nlm.nih.gov/37790805/


-----------------------------------------
Bill Munro - Hydrogen peroxide inhalation
-----------------------------------------

How to inhale Hydrogen Peroxide for Good Health This is a video
of 83 Year Old Bill Munro demonstrating how he inhales Hydrogen
Peroxide. For legal protection against lawsuits, etc. he also
recommends that...
https://www.youtube.com/watch?v=aT1_Rkl0B1M


A Natural Cure for Viral Infections and Cancer –
SetantaHypnotherapyClinic
https://setantahypnotherapy.com/a-natural-cure-for-viral-infections-and-cancer/

Hydrogen_Peroxide
https://web.archive.org/web/20040612084159/http://landrights.com/Hydrogen_Peroxide.htm

A Natural Cure for Viral Infections and Cancer - SetantaHypnotherapyClinic
https://setantahypnotherapy.com/a-natural-cure-for-viral-infections-and-cancer

Prostate Cancer
https://pcri.org/royal-1/2017/9/19/j8qay87k0sft1qoz7p1cc0m9otstru-fwwzb

Hydrogen peroxide fuels aging, inflammation, cancer metabolism and metastasis - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180186/

Oxidants Are Not All Created Equal | Could Hydrogen Peroxide Actually Be Good for Our Lungs? | American Journal of Respiratory and Critical Care Medicine
https://www.atsjournals.org/doi/full/10.1164/rccm.200902-0224ED

33% hydrogen peroxide as a Neoadjuvant treatment in the surgical excision of non-melanoma skin cancers: a case series | Journal of Otolaryngology - Head & Neck Surgery | Full Text
https://journalotohns.biomedcentral.com/articles/10.1186/s40463-020-00433-6

Hydrogen peroxide cancer treatment: Warnings, claims, and research
https://www.medicalnewstoday.com/articles/323591#takeaway

Hydrogen Peroxide Inhalation Method
http://arizonaenergy.org/News_10/News_Aug10/Hydrogen%20Peroxide%20Inhalation%20Method.htm

Alternatives in Cancer Therapy - Hydrogen Peroxide
http://educate-yourself.org/cn/hydrogenperoxidecancertherapybookexcerpt.shtml

Hydrogen Peroxide v. Prostate Cancer
http://educate-yourself.org/cn/hydrogenperoxideandprostatecancer14oct05.shtml

    Research has explored how high doses of vitamin C can produce
    hydrogen peroxide, a substance that can kill cancer cells. Unlike
    cancer cells, normal cells have the ability to break down
    hydrogen peroxide and prevent it from causing damage. This
    selective toxicity makes high-dose vitamin C an intriguing
    complementary approach in cancer care.

High Dose Vitamin C IV Drip London
https://integratedmedicine.co/complementary-cancer-care/iv-drips/iv-infusions-menu/high-dose-vitamin-c-iv-drip/

    Additionally, in all the cases high dose IV vitamin C also
    prolonged the lives of these cancer patients. Using this
    rationale, we also treated our patient with high dose IV vitamin
    C for prostate cancer and had a positive outcome.
    ...
    At normal physiologic concentrations, vitamin C acts as an
    antioxidant that inactivates reactive oxygen species. However at
    high pharmacologic concentrations vitamin C acts a pro-oxidant by
    generating oxidative species such extracellular hydrogen peroxide
    [13,14]. This hydrogen peroxide generated is delivered to tissues
    but not found in the blood [9]. Several in vitro studies have
    shown that the extracellular vitamin C, that generates hydrogen
    peroxide, kills away the cancer cells selectively but does not
    harm the normal cells [13]. This vitamin C mediated cancer cell
    death, is only obtained when vitamin C is administered
    intravenously.

    The mechanism of action of vitamin C is intricate, yet deadly to
    the cancer cells. Extracellular hydrogen peroxide from high doses
    of vitamin C diffuses into the cancer cells and causes toxicity
    in these cells by ATP depletion which eventually leads to cell
    death [16]. Additionally, hydrogen peroxide toxicity compromises
    membrane glucose metabolism and DNA integrity in the cancer cells
    [16]. In the normal cells hydrogen peroxide is readily
    neutralized by antioxidant enzymes such as catalase, glutathione
    peroxidase and superoxide dismutase. The level of these enzymes
    in cancer cells is low which causes the toxicity and cancer cell
    death [15].

    Additionally, the patient also took the Salerno Abe Factors
    which contains Green Tea Leaf extract, L-Carnosine,
    Quercetin, Alpha Lipoic Acid, Resveratrol and Benfotiamine,
    the highest available concentrations in the world. All the
    nutrients mentioned here have powerful antioxidant
    capabilities. Additionally, studies have shown that Quercetin
    exerts a direct, pro-apoptotic effect in tumor cells and
    blocks the growth of several human cell lines at different
    phases of the cell cycle [17].

    Emerging evidence now shows that concentrations of vitamin C at a
    concentration of 1000e5000 mmol/L are selectively toxic to cancer
    cells [9]. This concentration is achieved only through
    intravenous administration of vitamin C. In the case report
    presented above, using high dose IV vitamin C, we were able to
    show that the vascular area in the prostate gland disappeared
    after about 10 months of treatment. These data confer some
    validation that vitamin C can offer anti-tumor effects and
    further studies are warranted to learn its complete role.

High dose IV vitamin C for treatment of prostate adenocarcinoma - ScienceDirect
https://www.sciencedirect.com/science/article/abs/pii/S2186495013000023

60 Minutes New Zealand, Alan Smith Cured by Intravenous Vitamin C
https://www.bitchute.com/video/FFaBJrNT5Nqk/

Amazon.com: LivOn Laboratories Lypo–Spheric Vitamin C – 30
Packets – 1,000 mg Vitamin C & 1,000 mg Essential Phospholipids
Per Packet – Liposome Encapsulated for Improved Absorption – 100%
Non–GMO : Health & Household
https://www.amazon.com/Lypo-Spheric-Vitamin-Bioavailability-Professionally-Phospholipids/dp/B000CD9XGC?th=1

Can too much Vitamin C and D be a bad thing? - Urologist Singapore | Urohealth Medical Clinic
https://us14.proxysite.com/process.php?d=86yiZy5n5prZA4kUnOE67OUowm7BokJefZCqmBD6ZIrerj2zMu0XudeJyc7v6LLlNe0CNpg5sNqXMNk7ouAc4IatAIll&b=1



--------------------------------------------------------------------------------
Faith
--------------------------------------------------------------------------------

Mark Manson healed from prostate cancer - Riverlife
https://riverlifechurch.org.au/story/mark/


Bernard | Suffering from prostate cancer, I choose to let Jesus
heal me | MyStory.me
https://mystory-me.translate.goog/story/btuch/?_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=en-US&_x_tr_pto=wapp


My Journey with Prostate Cancer and what I believe to be God
incidents. - Personal stories - Prostate Cancer UK Online
Community
https://community.prostatecanceruk.org/posts/t10819-My-Journey-with-Prostate-Cancer-and-what-I-believe-to-be-God-incidents

 

Edited by member 03 May 2024 at 10:36  | Reason: Not specified

User
Posted 03 May 2024 at 20:49
JVDM you quote an impressive long list of articles there, and I have not done more than look at the titles and (where you provide it) summaries.

However it isn't clear that any of those articles includes a proper clinical trial, one where a large number of patients with equivalent diagnoses are divided randomly into two groups for either one of these alternative treatments or the treatment that would be normally proposed for that diagnosis, to discover whether the proposed treatment is actually better.

I think Andy would prefer a treatment that has been proven to work than one which sounds good but has never been properly tested. Even if it has fewer side effects in the short term, as Bob says the side effect you want to avoid is death.

User
Posted 03 May 2024 at 23:17

HI JVMD

My goodness the list is impressive but to be really useful has anyone carried out any meta-analysis of some of these therapies and claims? Until there is a proper scientific analysis based on double-blind trials etc I personally would not have any confidence in any of these therapies. 

 'Physics is like sex: sure, it may give some practical results, but that’s not why we do it.'                    Richard Feynman (1918-1988) Nobel Prize laureate

 

 

User
Posted 04 May 2024 at 10:17

Hi J-B and Pratap,

Thank you for your responses. I agree it's a lot to sift through and inconclusive, but maybe it will help Andy or someone else, with initial or adjuvant therapy options.

More than half of clinical trials fail to prove efficacy, even if they do, fewer than half report findings that are reproducible. But that's not why we do them...

Standard care has side effects, n=1 trials can be difficult to navigate.

The primary source of trial failure has been and remains an inability to demonstrate efficacy. Hwang et al. [58] assessed 640 phase 3 trials with novel therapeutics and found that 54% failed in clinical development, with 57% of those failing due to inadequate efficacy. 
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092479/

Randomized controlled trials (RCTs) are considered the ‘gold standard’ in research methodology, but fewer than half report findings that are reproducible.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599633/

The n-of-1 clinical trial: the ultimate strategy for
individualizing medicine? - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118090/

---

    Currently, men with prostate cancer that hasn’t spread outside
    the gland have several treatment choices. Because most men with
    prostate cancer are expected to live a long time, weighing the
    long-term side effects of different treatments is important. Side
    effects can include bladder and bowel problems, and difficulty
    with sexual functioning.

    Men with prostate cancer at low risk of spreading may undergo
    surgery to remove the whole prostate or radiation therapy.
    Some may instead choose active surveillance: observing the
    cancer over time with imaging and tissue biopsies, and only
    starting treatment if it grows. Men with cancer at higher
    risk of spreading may have surgery, or radiation plus therapy
    to suppress hormones that fuel prostate cancer growth.

Comparing side effects after prostate cancer treatment | National
Institutes of Health (NIH)
https://www.nih.gov/news-events/nih-research-matters/comparing-side-effects-after-prostate-cancer-treatment


    A large number of patients undergo radiation therapy (RT) as a
    standard care of treatment; however, RT causes erectile
    dysfunction (radiation-induced erectile dysfunction; RiED)
    because of late side effects after RT that significantly affects
    quality of life of prostate cancer patients. Within 5 years of
    RT, approximately 50% of patients could develop RiED. Based on
    the past and current research findings and number of
    publications from our group, the precise mechanism of RiED is
    under exploration in detail. Recent investigations have shown
    prostate RT induces significant morphologic arterial damage with
    aberrant alterations in internal pudendal arterial tone.
    Prostatic RT also reduces motor function in the cavernous nerve
    which may attribute to axonal degeneration may contributing to
    RiED. 

Radiation-induced erectile dysfunction: Recent advances and
future directions - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514009/

 

User
Posted 04 May 2024 at 14:41
We know that treatments of various kinds have improved greatly over the last ten years or so for men that have PCa but how much better it would be if it could be definitely established through trials that the incidence of PCa could be reduced in the first place, ideally by natural choice, injection or supplements. Unfortunately, there is no incentive for big Pharma who fund research for their expensive drugs to do so for anything that could potentially obviate or reduce the need for such high cost medication.

I remember when I was first diagnosed with PCa back in 2007 I did a lot of research on potential treatments and in doing do came upon somebody in the USA who treated his patients with high doses of injected Vitamin 'C', with good results but he was prosecuted to the point that he was forced to stop. (I believe one of the references alludes to intravenous injection of high doses of vitamin 'C'. I have not read the link but assume this equates with what I read). But essentially this was a form of treatment rather than something to stop PCa developing in the first place. The only way I can see of making progress in halting the development of PCa is for Government to fund trials. It took Government pressure to introduce measures to reduce cigarette smoking and thereby reduce the incidence of Lung Cancer and other medical issues, notwithstanding the loss of revenue generated on sales of tobacco. This was done against a background of obfuscation and delaying tactics by the tobacco industry.

Barry
 
Forum Jump  
©2024 Prostate Cancer UK