Originally Posted by: Online Community MemberI appreciate that much research suggests the aggressiveness of tumours rarely change although a few may do so. However some men for instance on biopsy are said to be Gleason 3:4 yet following surgery are told their Gleason score is 4:4. What happened in these circs.?
Hi IDK2
My Gleason pre op was 8 (3+5) and upgraded to 9 (4+5) post op. This was put down to two possible reasons.
1. Inaccuracies of previous biopsy sampling.
2. I had been on Bical for a couple of months prior to surgery and this can apparently change the look of cancer cells.
This is an interesting article
https://www.explorationpub.com/Journals/etat/Article/1002259
The thing that has most perturbed me about the diagnosis procedures are possible biopsy inaccuracies.
I hope that in future advances in technology improve their accuracy and that AI is used to read the histology thereby eliminating human interpretation of the samples.
Edited by member 03 Apr 2025 at 09:57
| Reason: Typo