I'm interested in conversations about and I want to talk about
Know exactly what you want?
Show search

Notification

Error

Choice advice

User
Posted 01 Apr 2025 at 19:52

Hello,

Having been on active surveillance for about 2 years I had a further biopsy and now need to have treatment-Gleason has changed to 4+3. Think I got lost in the system for a few months but now need to choose between surgery and RT+HT (did initially get offered nano knife as part of a trial but seems this is now not available). I have read all the leaflets etc re side effects and spoken to a Prostate UK nurse who says long term results for either are pretty similar. I know everyone's circs are different but still don't really know what's the most favourable route.

Any advice on how to choose gratefully received.

 

User
User
Posted 02 Apr 2025 at 01:53

If you have not yet done so, I suggest you have a meeting with a Urologist and an Oncologist. These will know from your scans and histology the type, location and extent of your cancer. Ask the Urologist whether the cancer is believed to be well contained and is confident that s/he can preserve one or both nerve bundles If the cancer is well contained you may take the view that you would opt for a Prostatectomy. (Should this not be successful it is likely that you could have RT as a salvage treatment but then be subject to the side effects of both forms of treatment). Also, you could ask the Oncologist what type of RT would be most suitable in your case. (I understand Focal Treatment has been ruled out). Ultimately, you may have to decide which option to choose. There are pros and cons for each treatment. It may help you if you read the 'Tool Kit' as here. https://shop.prostatecanceruk.org//our-publications/all-publications/tool-kit?limit=100

 

Edited by member 02 Apr 2025 at 01:57  | Reason: to highlight link

Barry
User
Posted 02 Apr 2025 at 07:33

Originally Posted by: Online Community Member
Having been on active surveillance for about 2 years I had a further biopsy and now need to have treatment-Gleason has changed to 4+3.

Hello Andrew.

Welcome to the forum mate.

It is unlikely that your Gleason score has progressed. Like me, it is more likely the your biopsy didn't pick up the more aggressive cancer cells. Your comment of being lost for a few months in the system also indicates that your active surveillance wasn't as good as it should have been.

I suggest anyone considering surgery views this video.

https://drive.google.com/file/d/1fyYTLZpxnB9HaR7O4xQ5Ff58Pj4Cn6ZB/view

Best of luck mate.👍

Edited by member 02 Apr 2025 at 07:34  | Reason: Typo

User
Posted 02 Apr 2025 at 08:42

I appreciate that much research suggests the aggressiveness of tumours rarely change although a few may do so. However some men for instance on biopsy are said to be Gleason 3:4 yet following surgery are told their Gleason score is 4:4. What happened in these circs.?This however does not help in making a decision on whether surgery or radiotherapy and hormone treatment may be the best form of treatment. In terms of offering a cure the success rates are similar. The only way to choose is to look at potential side effects of each type of treatment. Therein lies the problem because side effects are not uniformly experienced by all men. Some men prefer to know the tumour has been completely removed but for others it is not an issue. For others the risk of ED may make them decide not to choose surgery particularly if nerve sparring is not an option. Another person may think the long term risks of radiotherapy or side effects of hormone therapy make surgery preferable.  I think perhaps writing a pro and con list for both treatments and from that determine which form of treatment is best for you may be an option to consider. At the end of the day it is a personal choice, when the choice is available, as it is an individual’s  perspective of what potential side effects they feel most able to tolerate. No lay person should direct you one way or another. What may be worth exploring to inform your decision is whether surgery is likely to be nerve saving, is the tumour contained in the prostate, what radiotherapy regime would be offered to you and how long would you be on hormone treatment

Wishing you the very best of luck regardless of your final decision.

User
Posted 03 Apr 2025 at 09:36

Originally Posted by: Online Community Member
I appreciate that much research suggests the aggressiveness of tumours rarely change although a few may do so. However some men for instance on biopsy are said to be Gleason 3:4 yet following surgery are told their Gleason score is 4:4. What happened in these circs.?

Hi IDK2 

My Gleason pre op was 8 (3+5) and upgraded to 9 (4+5) post op. This was put down to two possible reasons.

1. Inaccuracies of previous biopsy sampling.

2. I had been on Bical for a couple of months prior to surgery and this can apparently change the look of cancer cells.

This is an interesting article 

https://www.explorationpub.com/Journals/etat/Article/1002259

The thing that has most perturbed me about the diagnosis procedures are possible  biopsy inaccuracies.

I hope that in future advances in technology improve their accuracy and that AI is used to read the histology thereby eliminating human interpretation of the samples.

Edited by member 03 Apr 2025 at 09:57  | Reason: Typo

 
Forum Jump  
©2025 Prostate Cancer UK