Profile is updated. We freaked on Monday when we went in for the 3 month Lupron and PSA check. After 4 months on Enza PSA went up from 6.6 to 22.4. Is it possible to have an increase in PSA but no cancer progression? We are very nervous about scans on Friday to see if there is any spread in the bones, to lymph nodes, or organs. We are only a year into this journey and already my husband's PSA is back up to nearly what it was when he was diagnosed. We were hoping for a lot more mileage out of the Lupron and Enza.