I found Tamoxifen stopped the pain pretty instantly. However, Tamoxifen does take a while to build up the working level in your blood so the first tablet might not last long. It has long half-life, actually a complicated bi-phasic half-life because the Tamoxifen Citrate is broken down by the liver into n-Desmethly Tamoxifen which is also an effective treatment and has a much longer half-life, so most of the treatment effect comes from this first metabolite. Tamoxifen works to prevent breast pain/growth in around 70% of cases. It will also reverse recent breast gland growth (gynecomastia), but not anything that's long-standing. It has no effect on breast fat growth (moobs, pseudogynecomastia).
Tamoxifen is a selective anti-estrogen, so while it blocks the estrogen receptors of the breast gland tissue, it doesn't block the estrogen receptors in bone, which means it doesn't cause osteoporosis (which is caused in women and men by lack of estrogens).
If you take Tamoxifen when not on hormone therapy, it may boost your Testosterone levels, as it blocks the androgen receptors in the hypothalamus and pituitary glands which sense and adjust Testosterone levels, causing them to request more Testosterone, so this may not be a good idea. (Bicalutamide does exactly the same, but blocks androgen receptors in the rest of the body so they can't see the Testosterone.)
Edited by member 14 Nov 2022 at 22:05
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