I have recently heard from an oncologist that the injection site reaction to Degaralix can be due to getting some of the injection on your skin surface, but I doubt that accounts for all cases.
There is an alternative which was approved by NICE last year, Relugolix, which is a daily tablet GnRH Antagonist (Degarelix is also a GnRH Antagonist). If you are getting severe injection site issues to Degarelix, then you could ask if you can have Relugolix instead. [Disclosure - I am a patient consultant to Accord, who sell Relugolix.]
The hormone therapy is almost certainly still working in terms of preventing growth of some cancer cells. What happens when you become castrate resistant is that new cancer mutations which are resistant to the actions of the existing drug start growing. However, the existing drug is still holding back the original cancer cells. It's only if the hormone therapy and chemo have wiped out the original cancer cells (which can happen) that the hormone therapy is no longer beneficial, but usually you stay on it.
You have to come off anti-androgen drugs like Bicalutamide, Enzalutamide, and the other *utamides if they stop working, because one way they can stop working is that the cancer learns to use them instead of Testosterone.
Edited by member 17 Feb 2025 at 13:12
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