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The million dollar question

User
Posted 24 Oct 2025 at 15:33
Hi Phil,
Sending a little encouragement your way, as the first clinical results from the Halda trials were announced today. I hope the pain is now being suitably managed and that you’re holding up alright. Wishing you all the very best for Monday!
User
Posted 24 Oct 2025 at 17:53

Totally agree. The early trial results look very promising, especially at the 25 mg and 50 mg doses which I think is what they're testing moving forward. The 50 mg group had a 70% rate for PSA halving (or better) and 40% of them saw their PSA fall over 90%. That is obviously a very small sample size - but it's a success rate that is about twice as good as Cabazitaxel and also better than Lutetium-177, if those results are repeated. 


So that's positive news, probably explains why the Marsden people were optimistic, and with good resson. You're in very good hands, Phil. 


We have a consultation for my father next Friday with his oncologist to discuss trials. Do you happen to know if they're still accepting patients for this trial at the Marsden? We're looking at this one and the PAnTHA one at UCLH for Actinium-225 - given Lutetium-177 didn't make a dent in my father's disease, this trial could be a better option if it's still possible to get him into it. Weirdly there's nothing online about this trial coming to the UK, it's all about the US. I might enquire with the oncologist next week.

User
Posted 25 Oct 2025 at 09:05

Hi guys


Thanks for your responses


Yes have looked at feedback from early results from trial and it looks promising.


Pain from lower back and rib area are under control with stronger pain killers but QOL is still ok.


Blood tests and consultation monday and take the magic tablet Tuesday morning🤞


Unfortunately I think the window for signing up for this trial is closed but they've always got trials in mind.


Best wishes phil 

User
Posted 29 Oct 2025 at 11:19
Hi Phil, Hope your bloods etc went okay and you got the magic pill, glad to hear pain meds are helping now, it is a shame you cannot have radio therapy to help the pain also. Take care and thanks for taking on these trials
User
Posted 30 Oct 2025 at 08:43

Hi Airyarriss


Thanks for your message,have stated taking the new tablet after 3 days of tests at the royal marsden,PSA is now just shy of 300 will no if the trial is working in the next few months.


In the meantime I feel my aches are getting worse so I do hope this treatment has sone reaction as I feel I'm running out of time to be healthy enough to travel and start another.


But I'll keep positive and strong💪 


Best wishes all 


Phil 

User
Posted 30 Oct 2025 at 17:06
Best wishes as ever Phil. Keep doing what makes you happy ok. Fingers crossed all goes well.
User
Posted 30 Oct 2025 at 17:32

Phil ,hope the trial is a success for you, never sure if aches and pains are old age, cancer or the meds.


Thanks Chris 

User
Posted 30 Oct 2025 at 22:35
Good luck Phil, fingers crossed for you...
User
Posted 30 Oct 2025 at 22:35
Good luck Phil, fingers crossed for you...
User
Posted 31 Oct 2025 at 08:23

Hi Guys 


Thanks for the response,i feel like a 76 year old bloke in a 56 year old body.


Best wishes Phil 

User
Posted 31 Oct 2025 at 17:47
Keep your sexual preferences to yourself please Phil...
User
Posted 31 Oct 2025 at 17:58

Originally Posted by: Online Community Member
Keep your sexual preferences to yourself please Phil...


😂 I thought it, but didn't dare post it. 


I've already been yellow carded this week. 😳

Edited by member 31 Oct 2025 at 18:07  | Reason: Typo

User
Posted 31 Oct 2025 at 22:13

Ha ha


Nice one 👍 

User
Posted 05 Nov 2025 at 13:13
Phil all I can say is you know how you feel, Hope the trial is a success and the pains ease take care
User
Posted 09 Nov 2025 at 08:19

Hi all


Little update from a personal view.


Have been on the new tablets for less than 2 weeks but I can't believe the difference its made,yesterday all I took was paracetamol and went to bed without taking a painkiller!


2 werks ago I was on codeine and morphine to get me through the day,obviously scans and x-rays will show the true effect which i have in January,but in myself i feel that im improving.


I know its sounds strange but its a scary moment.


Will keep you informed when I know more.


Best wishes all Phil.

User
Posted 09 Nov 2025 at 10:36

Hi, Phil.


Thanks for the update, mate. It's great to know that you're feeling some improvement and are more comfortable. 

User
Posted 09 Nov 2025 at 14:37

That's lovely to hear some good news, how you feel is a fantastic result 


 

User
Posted 09 Nov 2025 at 16:31

Brilliant news Phil long may it continue 


wishing you all the very best


Ann

User
Posted 09 Nov 2025 at 17:20
So happy reading your update Phil! Really glad you are feeling so much better. Long may it continue!
Here's to hoping this new therapy will be a game-changer.
User
Posted 09 Nov 2025 at 20:11

Really encouraging thanks for the update. Best wishes

User
Posted 12 Nov 2025 at 11:55

Hi guys 


Quick update and its great news after 2 weeks on the new trial my PSA has halved from 283.2. to 123.6 !!!!!


That's the lowest its been this year 


Happy days......Phil 

User
Posted 12 Nov 2025 at 12:26

Thanks for the update mate. Fabulous news!

User
Posted 12 Nov 2025 at 13:08

unbelievable news, thats fantastic, that must be a really potent witches brew.


 


 

User
Posted 12 Nov 2025 at 15:21

Hi Phil,


Thats fantastic news mate.  :)


Jay

User
Posted 12 Nov 2025 at 16:49

That's pretty amazing, great news.

User
Posted 12 Nov 2025 at 23:18
Wow!! Do you know what you are getting?
User
Posted 13 Nov 2025 at 11:57

Delighted by your news.   Stay strong, your courage helps others.


 

User
Posted 13 Nov 2025 at 12:56

Thanks for all your responses guys.


It's a phase 1/2 halda trial HD-0195 tablet form francij1


Will keep you all updated


Regards Phil 

 
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