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The million dollar question

User
Posted 24 Oct 2025 at 15:33
Hi Phil,

Sending a little encouragement your way, as the first clinical results from the Halda trials were announced today. I hope the pain is now being suitably managed and that you’re holding up alright. Wishing you all the very best for Monday!

User
Posted 24 Oct 2025 at 17:53

Totally agree. The early trial results look very promising, especially at the 25 mg and 50 mg doses which I think is what they're testing moving forward. The 50 mg group had a 70% rate for PSA halving (or better) and 40% of them saw their PSA fall over 90%. That is obviously a very small sample size - but it's a success rate that is about twice as good as Cabazitaxel and also better than Lutetium-177, if those results are repeated. 

So that's positive news, probably explains why the Marsden people were optimistic, and with good resson. You're in very good hands, Phil. 

We have a consultation for my father next Friday with his oncologist to discuss trials. Do you happen to know if they're still accepting patients for this trial at the Marsden? We're looking at this one and the PAnTHA one at UCLH for Actinium-225 - given Lutetium-177 didn't make a dent in my father's disease, this trial could be a better option if it's still possible to get him into it. Weirdly there's nothing online about this trial coming to the UK, it's all about the US. I might enquire with the oncologist next week.

User
Posted 25 Oct 2025 at 09:05

Hi guys

Thanks for your responses

Yes have looked at feedback from early results from trial and it looks promising.

Pain from lower back and rib area are under control with stronger pain killers but QOL is still ok.

Blood tests and consultation monday and take the magic tablet Tuesday morning🤞

Unfortunately I think the window for signing up for this trial is closed but they've always got trials in mind.

Best wishes phil 

User
Posted 29 Oct 2025 at 11:19
Hi Phil, Hope your bloods etc went okay and you got the magic pill, glad to hear pain meds are helping now, it is a shame you cannot have radio therapy to help the pain also. Take care and thanks for taking on these trials
User
Posted 30 Oct 2025 at 08:43

Hi Airyarriss

Thanks for your message,have stated taking the new tablet after 3 days of tests at the royal marsden,PSA is now just shy of 300 will no if the trial is working in the next few months.

In the meantime I feel my aches are getting worse so I do hope this treatment has sone reaction as I feel I'm running out of time to be healthy enough to travel and start another.

But I'll keep positive and strong💪 

Best wishes all 

Phil 

User
Posted 30 Oct 2025 at 17:06
Best wishes as ever Phil. Keep doing what makes you happy ok. Fingers crossed all goes well.
User
Posted 30 Oct 2025 at 17:32

Phil ,hope the trial is a success for you, never sure if aches and pains are old age, cancer or the meds.

Thanks Chris 

User
Posted 30 Oct 2025 at 22:35
Good luck Phil, fingers crossed for you...
User
Posted 30 Oct 2025 at 22:35
Good luck Phil, fingers crossed for you...
User
Posted 31 Oct 2025 at 08:23

Hi Guys 

Thanks for the response,i feel like a 76 year old bloke in a 56 year old body.

Best wishes Phil 

User
Posted 31 Oct 2025 at 17:47
Keep your sexual preferences to yourself please Phil...
User
Posted 31 Oct 2025 at 17:58

Originally Posted by: Online Community Member
Keep your sexual preferences to yourself please Phil...

😂 I thought it, but didn't dare post it. 

I've already been yellow carded this week. 😳

Edited by member 31 Oct 2025 at 18:07  | Reason: Typo

User
Posted 31 Oct 2025 at 22:13

Ha ha

Nice one 👍 

User
Posted 05 Nov 2025 at 13:13
Phil all I can say is you know how you feel, Hope the trial is a success and the pains ease take care
User
Posted 09 Nov 2025 at 08:19

Hi all

Little update from a personal view.

Have been on the new tablets for less than 2 weeks but I can't believe the difference its made,yesterday all I took was paracetamol and went to bed without taking a painkiller!

2 werks ago I was on codeine and morphine to get me through the day,obviously scans and x-rays will show the true effect which i have in January,but in myself i feel that im improving.

I know its sounds strange but its a scary moment.

Will keep you informed when I know more.

Best wishes all Phil.

User
Posted 09 Nov 2025 at 10:36

Hi, Phil.

Thanks for the update, mate. It's great to know that you're feeling some improvement and are more comfortable. 

User
Posted 09 Nov 2025 at 14:37

That's lovely to hear some good news, how you feel is a fantastic result 

 

User
Posted 09 Nov 2025 at 16:31

Brilliant news Phil long may it continue 

wishing you all the very best

Ann

User
Posted 09 Nov 2025 at 17:20
So happy reading your update Phil! Really glad you are feeling so much better. Long may it continue!

Here's to hoping this new therapy will be a game-changer.

User
Posted 09 Nov 2025 at 20:11

Really encouraging thanks for the update. Best wishes

User
Posted 12 Nov 2025 at 11:55

Hi guys 

Quick update and its great news after 2 weeks on the new trial my PSA has halved from 283.2. to 123.6 !!!!!

That's the lowest its been this year 

Happy days......Phil 

User
Posted 12 Nov 2025 at 12:26

Thanks for the update mate. Fabulous news!

User
Posted 12 Nov 2025 at 13:08

unbelievable news, thats fantastic, that must be a really potent witches brew.

 

 

User
Posted 12 Nov 2025 at 15:21

Hi Phil,

Thats fantastic news mate.  :)

Jay

User
Posted 12 Nov 2025 at 16:49

That's pretty amazing, great news.

User
Posted 12 Nov 2025 at 23:18
Wow!! Do you know what you are getting?
User
Posted 13 Nov 2025 at 11:57

Delighted by your news.   Stay strong, your courage helps others.

 

User
Posted 13 Nov 2025 at 12:56

Thanks for all your responses guys.

It's a phase 1/2 halda trial HD-0195 tablet form francij1

Will keep you all updated

Regards Phil 

User
Posted 18 Nov 2025 at 11:42

Hi Guys

Day 1 cycle 2 of trial.

PSA down again to 83.....great news....Happy days 🙌 

Will keep you updated,as always stay strong 💪 and keep battling everyone.

Best wishes Phil 

User
Posted 18 Nov 2025 at 12:33
fantastic news Phil

User
Posted 18 Nov 2025 at 17:14
Phil you’re a bl***y superstar and fair play for keeping the fight. Hope this is a potential cure and certainly available for all. Goalhangers passing hit us all hard at this stage of our travels. I had a bad week when his son contacted me. Just wishing you nothing but the very best fella.
User
Posted 18 Nov 2025 at 17:43

GREAT NEWS, MATE! 🍻

User
Posted 18 Nov 2025 at 20:35

Hi Guys thanks for the replies 

Apparently Johnson & Johnson have just brought out the sponsers of the drug I'm on (Halda) for $3 Billion !!! So there must be something in it.

Cheers Phil

User
Posted 19 Nov 2025 at 05:34
Great news Phil!!!
User
Posted 19 Nov 2025 at 08:34
Any significant side effects for you? I read the trial details and it's very interesting, sounds like a very efficient cellular targeted cancer specific chemo therapy, so hopefully you are getting lots of effect for minimum side effects?

Re Johnson and Johnson they obviously thought it was a "buy", as did I after I read the trial paper, they outbid me 😂.

User
Posted 19 Nov 2025 at 09:50

Lol Francij 

It's early days but no real side effects as yet.

If I was being picky perhaps an occasional light headache,a bit of fatigue and sometimes nausea,but I'll take that on the chin any day of the week for the benefits.

 

User
Posted 19 Nov 2025 at 10:39

Originally Posted by: Online Community Member
Re Johnson and Johnson they obviously thought it was a "buy", as did I after I read the trial paper, they outbid me 😂.

🤣

During Covid 19, when they were racing to produce a vaccine, and we were socially distancing. They changed their name to Johnson..........&..........Johnson.

 

User
Posted 19 Nov 2025 at 18:42

Oh dear Adrian!

User
Posted 20 Nov 2025 at 06:51

Phil, I am delighted for you mate, it must be a massive relief.

Here's to a continued reduction in the PSA down to as little as possible.

From a selfish point of view this sounds like it could be a game changing treatment for us Incurables.

 

User
Posted 20 Nov 2025 at 07:38
In response to both Adrian and Paul - Indeed! J and J :-) is (now, with the Halda acquisition) seriously invested in multiple totally different new frontiers in therapeutics for mCRPC. Really hoping for long-term positive outcomes for HD-0195 AND their bispecific T-cell redirecting antibodies....
User
Posted 20 Nov 2025 at 10:29
Brilliant news Phil keep up the good work. All the very best.

Jeff.

User
Posted 20 Nov 2025 at 19:48
Some absolute legends on here, i tip my hat. I am following your journeys which has given me the wake up call i need to get on with it.

I can only echo a lot of what others have written. Your determination and fight is insperational Phil.

I started this journey 7 weeks ago and felt alone and desperate even with a family so close and strong. The men with this and some of their amazing partners have moved me with their insights and experiences. Thank you all for taking the time to post your updates as it has helped me to turn the corner. Upwards and onwards is the only way to go.

User
Posted 20 Nov 2025 at 21:41

Phil,

I'm so happy to hear this I could cry. Your psa finally getting ground down!!!

Fabulous xx

Mrs MAS

User
Posted 21 Nov 2025 at 08:20

Thankyou so much for your messages guys.

I won't give up Mrs Mass,Allan wouldn't won't me too x

 
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