Hello, my husband was prescribed cyproterone in July 2019 for constant hot flushes and although it was successful in controlling the flushes it left him feeling extremely fatigued and flat. He decided to stop taking it as a result, and said he felt much more alert, but after about 3 weeks the flushes returned and he was once again unable to sleep.He decided to persevere with cyproterone and now has good quality sleep but does feel that it is a trade off.