Search results for "cabazitaxel"

I was informed by a leading PC specialist in the UK that Cabazitaxel was designed specifically for men where docetaxel had failed - definitely worth pursuing this treatment option.

Hi everyone,
I’m looking for some positive news/rays of hope this evening. My Dad (a very young and fit 70yr old) was diagnosed Dec ’23 with T3a N0 M1, with mets to the bones. The Urologist advised it was Gleason score 10. 
Initial treatment was apalutamide, the oncologist was not supportive of triplet therapy at the time. This did reduce the PSA for a few months, but not ever below 4, and then it started to rise. Repeat bone scans showed disease progression of existing mets and few areas. He had x6 cycles of Docetaxel and again the PSA decreased, but very slowly and not significantly and it then rapidly started to rise from cycle 4. The oncologist has stopped chemo now as it’s obviously failed. 
I had to ask about Olaparib, which the oncologist agreed to test for, but didn’t think he’d have the BRCA gene due to how the cancer was behaving etc. I’ve since been doing my own research and wanted to know if anyone had had a good result from Cabazitaxel when Docetaxel has failed?
I’ve also been looking into the Enhertu trial and wanted to know if anyone has experience of this?
Trying to be positive, but the oncologist was very clear the cancer was aggressive and he wasn’t giving us much hope.

Hi guys, just popped my head in to say hello.

Hope you all had a good weekend ? We had a 40th wedding anniversary party Saturday which was lovely. We are 43 years this year. Remember on our 10th thinking that was good…..

Funny thing was i stopped drinking wine after an hour or so as i just had had enough. The wife was fine and got slightly tipsy… Don’t know if going off the wine is a permanent thing due to the damage done to my taste buds by the chemo or just one of those days.

I went out with a couple of old work mates last week and had the low alcohol beer. I usually drive there but this time the missus didn’t want me driving so she drove me there. I was a couple in before I realised I could’ve had normal beer …! Silly me but it did mean less visits to the toilet. Had a nice meal and some good chat.

CT scan yesterday which was  ok. Even the drink you take before didn’t taste too bad. When i started on this journey the drink was horrid. Won’t know results till 18th March. Hopefully no spread to organs or the Radium 223 is off the cards. And i presume then its straight onto the Cabazitaxel.

Was some good football and rugby over the weekend. Well chuffed with the Spurs result . Got to get past Man City on Wednesday. Going to sit down and watch that one …. Maybe with a glass of wine.

Still feeling very weak and breathing not so good but hopefully that will change as the reduced steroids take affect. I shall start measuring my weight to see if it’s affected . I was just over 13 stone then i lost loads to get well below 11 stone which was great other than I felt like absolute s***. So if I can get to 11 stone and feel ok then that’s a result.

Anyways time for coffee and a biscuit.. or maybe 2 …

Take care guys, 

Phil

Hi Leila. 

Yes not sure about the Radium treatment. They are going to check I have no spread to organs as they can’t do the radium then. 

I did ask about Cabazitaxel and he said that would be after the radium. As it is another chemo drug I’m not sure how I’d get on with it as I wasn’t well at all after 7 sessions of Docetaxel. 

Im slowly getting my head around where I am on this journey. It’s hard to accept but it’s the only way forward. Taking strength from the guys who’ve already trodden this path before me.

Hopefully a few more holidays yet but unlikely to be abroad again . Still plenty left to see in good old Blighty 👍

take care all, 

Phil

Wendy n Dave

Hi Phil. 

oh it’s a shame you’re on the Cabaxitaxel and not the trial drug. I would feel the same. But saying that Cabazitaxel is a well proven drug and fingers crossed it helps out. 

Bit of a pain that you’ve got to travel for it now. Can you ask if you can have it near where you live and they can still see the results ?  

Got everything crossed for you Phil. 👍

Phil

Finally had my meeting with my consultant, had to postpone it three weeks because of a kidney issue that absolutely floored me, but that seems to be sorted now.

The 6 cycles of Docetaxel I had from August to Dec '24 did keep my PSA suppressed, and CT scans show that it did significantly shrink the met on my liver and a couple of others, too.  However, I couldn't have carried on with it.  My PSA has now risen to 128 (from 33 in December), but that's to be expected as I still have a prostate and multiple active mets all over the place. 

So we crack on for another 3 months, and we'll see how things go.  I may consider Cabazitaxel chemo if I start to get symptoms again, and I've asked to be put forward for clinical trials as they come up:  at the very least, it would be interesting to know what's out there. 

The good news is, I feel healthy, getting my strength back after the kidney problem, going for long walks with my fam (weather permitting) and itching to get out on the bike too (weather permitting).  The nights are getting lighter, the days a little warmer, roll on Springtime!

Oh that’s a bummer. I do understand it but I’d still like to wheedle my way onto the experimental arm. Mind you it’s possible Cabazitaxel will work as well. It’s a well proven drug . 

Good luck

Phil

Hi Phil 

Keep positive mate,did you ask about clinical trials, cabazitaxel or letethium 177?I find it strange they don't ask you to have a blood test before every oncology appointment I went yesterday for a blood test and my next appointment isn't until end of Jan,I have one every month.

Best wishes Phil 

Yes, got lots of questions this time and no idea why Cabazitaxel hasn’t been mentioned yet. I’ll update later or tomorrow. 

Cheers

Phil