Search results for "radium 223"

Hi Parkie

The positive thing was the ALP coming down that indicates that the bone metastases were being treated ...  but the psa reached a nadir after 4 cycles.  pity that you can not paste the PSMA images but I would guess that this showed big reduction ...  

Further treatments using Lu-PSMA require the metastasis to be PSMA avid ...   so these PSMA-PET scans are very important.  Maybe the Radium-223 treatment is a better option?

Good luck with treatment.

ciao  Crispin

Hi bookworm my husband finished Radium 223 in April this year, the main problem he had was stomach issues and tiredness, the scans he had after showed it had worked on some parts but not on others at the moment his PSA is close to 600 but oncologist says try not to worry about that, he is also on monthly alondronic infusions, the oncologist is arranging more scans within the next couple of months, he said he can only go on how my husband is feeling and atm he is up and down

many thanks 

ann

Hi, Bookworm76

I'm very sorry to hear about your husband's condition. There doesn't appear to have been that many conversations on Ra223, and unfortunately, what there is, doesn't make particularly good reading.

https://community.prostatecanceruk.org/posts/t33535-Next-step---Radium-223

https://community.prostatecanceruk.org/posts/t31828-Radium-223-side-effect

https://community.prostatecanceruk.org/posts/t30393-223Radium-treatment

https://community.prostatecanceruk.org/posts/t13243-Radium-223---the-highs-and-the-lows

However, our site's piece on the treatment sounds a bit brighter.

https://prostatecanceruk.org/prostate-information-and-support/treatments/radiotherapy-for-advanced-prostate-cancer

Somehow, I missed your earlier thread conversation on the progression of your husband's disease.

https://community.prostatecanceruk.org/default.aspx?g=posts&m=312625#post312625

I found it very touching. My heart goes out to you. I hope the proposed treatment manages to give you both a bit more comfort.

Hi Bookworm76, my husband had Ra223 last year and managed 4 injections before the treatment was stopped due to disease progression,  I have put all our info in my profile.  The process seemed straightforward and he had no additional side effects.  The problem was that it didn't work but then not much has worked for him.  Good luck with the treatment.

My husband has just had his first injection of Radium-223 for secondary bone cancer from Prostate Cancer.  From the scarcity of information on the various forums, it seems that it isn’t used very much (probably due to the expense).  We have general information but it would be nice to hear people’s actual experiences, e.g. the level of fatigue they had, how much it affected their day to day life.  I realise not everyone gets the same side effects but it would give us some idea of how others coped.

Hi All

Here is an update on the Lutetium treatment now that the course of treatment has been completed.

23/09/2025 - Cycle 1 - PSA 5.18, ALP 304

Felt a little nausea during the first week after the treatment. A little off my appetite, by apart from that all was ok.

04/11/2025 - Cycle 2 - PSA 0.5, ALP 224 

No side effects after cycle 2

16/12/2025 - Cycle 3 - PSA 0.43, ALP 216

No side effects after cycle 3

27/01/2026 - Cycle 4 - PSA 0.36, ALP192

No side effects after cycle 4

10/03/2026 - Cycle 5 - PSA 0.37, ALP 183

Felt a slight nausea on the first week, after cycle 5 but nothing too bad

21/04/2026 - Cycle 6 - PSA 0.47, ALP 153

No side effects after cycle 6

03/06/2026 PSMA Scan Before and after scan results, which were really positive. Unfortunately I cannot paste the images.

17/06/2026 - I visited Spire for a consultation with one of the consultants. The advice was to have further blood tests every two months to monitor the situation, with the possibility of receiving Radium-223 treatment if and when there are signs of change.

Further blood tests:

09/06/2026 - PSA 0.7 ALP 172

28/07/2026 - PSA 2.0 ALP 194

Back under NHS and CT and Bone Scan taken on 16/08/2026 - Nothing to report

Edited: by member 18 Aug 2026 at 08:45  | Reason: Not specified

My husband has been referred for this as he has extensive active bony mets.

He was diagnosed in Jan 25 with stage 4, Gleason 9.

Apalutamide failed after 6 months and docetaxcel didnt work sadly.

He had a displaced subcapital fracture ( top of femur) due to the cancer and had surgery ( total hip replacement) on 17th June. 

Has anyone experience of radium 223?

Thanks

Hello

This is my first time posting here. My husband was diagnosed in Jan 25 with stage 4 prostate cancer. He had always had a PSA test yearly as a school friend had prostate cancer. He had a completely normal test in March 24. At the end of October 24, he developed a bad pain in his lower back/ left butyock..he thought it was from jumping off a trailer as we had just sold our farm. He saw physios and they just said it was deep seated...he is vety stoic and said it was improving...just before Christmas he was finding it uncomfortable to sit and we were due to go on a long holiday to Asia at end of January...so we asked GP if wecould pay for a private MRI scan...I thought it was a trapped nerve. The private consultant agreed for the MRI without seeing him as he was booked up and knew we were travelling. He had the scan on 31st Dec and we were due to see the consultant in late Jan. We got a call on 7th Jan...he was so apologetic but said he had extensive bony metastases in his pelvis and would send an urgent referral to our GP. My husband never had any symptoms, never got up at night to pee. When we knew he had bony mets ( basically whole pelvis was black) GP did an examination and said prostate was normal....the next day PSA came back as 94. Apparently it was just a small nodule which is why no symptoms. His gleason score is 9. Initially apalutamide worked and PSA came down to 0.6...but last summef he suffered a hairline fracture at thd top of hus femur, due to the cancef and developed a lytic lesion in his acetabulum. He was able to have targeted radiogherapy to the area and after 3 months in a wheelchair, in October he regained his mobility.

In October his PSA started rising. In January he started docetaxel. He had 6 rounds but unfortunately his PSA kept rising....kept thinking it was a flare but in May, oncologist said it wasnt working and his PSA was 112.

Unfortunately about a week later, my husband suddenly had increased hip pain and an MRI scan showed a slightly displaced fracture at the top of his femur ( due to the cancer). He was admitted for an emergency total hip replacement. There was cancer in his acetabulum so I think a lot of cement was used. Unfortunately he has been quite unwell since as his serum iron dropped to 3 and his Hb was 90 and CRP 118.

His next option is Radium 223 but only when the hip is healed and his bloods return to normal...otherwise not much else left...so been looking into ivermectin and mebendazole. I know there are not any big trials but if no othrr options it has to be worth a go.

I think there is someone on here whose husband is on this treatment so I would really like to reach out to her.

I know there is a lot of controversy about this but it has to be worth a try.

Thank you if you have read this as it is rather long!