Search results for "radium 223"

My husband has been referred for this as he has extensive active bony mets.

He was diagnosed in Jan 25 with stage 4, Gleason 9.

Apalutamide failed after 6 months and docetaxcel didnt work sadly.

He had a displaced subcapital fracture ( top of femur) due to the cancer and had surgery ( total hip replacement) on 17th June. 

Has anyone experience of radium 223?

Thanks

Hello

This is my first time posting here. My husband was diagnosed in Jan 25 with stage 4 prostate cancer. He had always had a PSA test yearly as a school friend had prostate cancer. He had a completely normal test in March 24. At the end of October 24, he developed a bad pain in his lower back/ left butyock..he thought it was from jumping off a trailer as we had just sold our farm. He saw physios and they just said it was deep seated...he is vety stoic and said it was improving...just before Christmas he was finding it uncomfortable to sit and we were due to go on a long holiday to Asia at end of January...so we asked GP if wecould pay for a private MRI scan...I thought it was a trapped nerve. The private consultant agreed for the MRI without seeing him as he was booked up and knew we were travelling. He had the scan on 31st Dec and we were due to see the consultant in late Jan. We got a call on 7th Jan...he was so apologetic but said he had extensive bony metastases in his pelvis and would send an urgent referral to our GP. My husband never had any symptoms, never got up at night to pee. When we knew he had bony mets ( basically whole pelvis was black) GP did an examination and said prostate was normal....the next day PSA came back as 94. Apparently it was just a small nodule which is why no symptoms. His gleason score is 9. Initially apalutamide worked and PSA came down to 0.6...but last summef he suffered a hairline fracture at thd top of hus femur, due to the cancef and developed a lytic lesion in his acetabulum. He was able to have targeted radiogherapy to the area and after 3 months in a wheelchair, in October he regained his mobility.

In October his PSA started rising. In January he started docetaxel. He had 6 rounds but unfortunately his PSA kept rising....kept thinking it was a flare but in May, oncologist said it wasnt working and his PSA was 112.

Unfortunately about a week later, my husband suddenly had increased hip pain and an MRI scan showed a slightly displaced fracture at the top of his femur ( due to the cancer). He was admitted for an emergency total hip replacement. There was cancer in his acetabulum so I think a lot of cement was used. Unfortunately he has been quite unwell since as his serum iron dropped to 3 and his Hb was 90 and CRP 118.

His next option is Radium 223 but only when the hip is healed and his bloods return to normal...otherwise not much else left...so been looking into ivermectin and mebendazole. I know there are not any big trials but if no othrr options it has to be worth a go.

I think there is someone on here whose husband is on this treatment so I would really like to reach out to her.

I know there is a lot of controversy about this but it has to be worth a try.

Thank you if you have read this as it is rather long!

I hope that with hubbies treatment, you and your husband will still enjoy happy years, albeit with the need for careful monitoring.

My hubby has aggressive, incurable G9 PC diagnosed in 2015.  Since last year the cancer has spread into lymph nodes and bones despite all the hormone therapy and 10 cycles of Docetaxel only had a minimal effect on it.  His PSA, which had reduced from 95 to 6.4, started rising again as soon as it finished.   He’s just had his 2nd cycle of Cabazitaxel (apparently known as a ‘last resort’ chemo) and we’ve yet to find out whether it’s started working.  Possibly some RA-223 after that.

From the posts by others in much the same situation, it looks very much as though the options are running out and suddenly it feels like the end of the road is approaching.  We’re trying to be philosophical (after all, he’s lasted longer than many men) and are playing it down to friends and acquaintances.

Unlike me, my hubby has always rejected forums, support groups, counselling, research etc so has  always been a bit in the dark about the various treatments he’s been on.  I haven’t told him about the above-mentioned posts, but even he has the feeling that time is running out at last going by some of his recent remarks.

His way of forgetting about it is to immerse himself in his voluntary work while I find Buddhist mindfulness meditation helpful but it always feels as if there’s a dark cloud overhead these days and times when I start worrying about getting end of life care (after my friend’s awful experience); also dreading being without him after having been together for 57 years.  All we can do now is make the most of our time together.

Sorry – just needed to vent!

Hi Phil,

Thanks for your reply.

I’ve read other people’s comments that they didn’t feel so bad on Cabazitaxel.  Peter’s worst ones last time were the oral thrush and strange taste.

I’m sorry it wasn’t as successful for you as hoped.  Although Peter had all 10 Docetaxel cycles his PSA only dropped to 6.4 from 95 and started rising again as soon as he’d finished the Docetaxel despite the Zoladex and steroids.  The last BT in September showed 27 but it’s probably shot up again since then. The PC was back in the  lymph nodes, bone mets too now in femur, rib and clavicle although he’s not in pain at present.

Beginning to wonder how many options are left.  Radium 223 has been vaguely mentioned.   Meanwhile he starts the Cabazitaxel next week.

Wishing you well on your own journey.

Hazel