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Swollen & bruised scrotum and penis after cryotherapy 2 replies
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User
Posted: 09 Apr 2025 at 00:48

The two treatments offered are those most frequently offered and both have pros and cons which the patient shoud carefully consider. There are other forms of treatment which mainly come under the description of Focal Therapy. It is not widely administered and sometimes has to be repeated but usually side effects are considerably less severe. A prerequisite is that a patient's histology, tests and scans need to be assessed by a Focal Specialist to ascertain whether he is a suitable candidate. Focal Therapy can be used as as a primary treatment or as a salvage treatment for failed RT. Examining this possibility would most likely delay treatment, particularly if surgery was your husband's final decision as surgeons normally have waiting lists. With Surgery the idea is to remove the Prostate, which is the opposite of Focal Treatment which aims only to anilalate the significant tumouts, thereby preserving function. It has to be said that Focal Treatment as with pther forms of treatment has it's failurers and successes, so also needs to be well considered before being chosen. There are other forms of Focal Therapy but the ones used most oftenin theUK are High Intensity Focal Ultrasound (HIFU) and Cryotherapy depending on the tumour location, with Nanoknife (Irreversable Electroporation) being a more recent alternative.

Edited: by member 09 Apr 2025 at 00:50  | Reason: Not specified

Barry
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    User
    Posted: 30 Jan 2025 at 14:53

    I had irreversible electroporation on the 3rd December, HIFU or Cryotherapy wasn't an option according to two urologists. I had a catheter for a week as the cancer was near the urethra.  Two week ago I had urine analysis and everything is ok. I stopped peeping blood three weeks ago still eyaculating blood ( very little as I have dry eyaculación) after the electroporation I had normal eyaculación but after two week dry ejaculation again ( which is a shame because no matter whatever the urologists say that has nothing to do orgasm it is much more pleasure to ejaculate something). At the end of February I'll have my PSA checked and hope is goes down from the last result which was 9'5. 

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      User
      Posted: 02 Dec 2024 at 13:50

      4 days ago I had cryotherapy to kill cancer in my prostate, 2 days after procedure my scrotum and base of penis are showing heavy bruising and some swelling, is this anything I should worry about ? Has anyone else had a similar experience ? 

      Edited: by member 02 Dec 2024 at 14:01  | Reason: Add information

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        User
        Posted: 08 Oct 2024 at 21:33

        CNS sent me the rejection reason:-


        PSMA PET is only indicated for patients with BCR where salvage treatment (surgery/RT/cryotherapy is being actively considered. It is not indicated to decide on use of HRT post salvage.


        she also sent me the criteria list and the most obvious one, is “should have at least two consecutive PSA levels of 0.2 or greater” My husband only has one which makes me question why the oncologist requested the scan so early.

        Edited: by member 08 Oct 2024 at 21:50  | Reason: Not specified

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          User
          Posted: 02 Oct 2024 at 19:41
          Further Radiotherapy as salvage treatment could depend on the paths of the original RT.

          To revert to the original Focal Treatment referred to by the OP, I had HIFU twice for failed RT. Focal Treatment for treatment can be given to suitable men ass a primary or salvage treatment. A small proportion of men have this compared with Surgery or one of the forms of Radiotherapy. In the UK most men who have Focal treatment have HIFU with a lesser number having Cryotherapy, much depending on the location of the tumour(s).

          It is correct that the thinking behind Focal is to eradicate only significant tumour thereby preserving as much function as possible. This can mean that a further treatment is necessary as it was in my case. My last MRI was clear and I have a low and stable PSA so was told I am in remission. After 2 years without one, I am due for another MRI this coming December.

          So as it stands, I am happy with HIFU and the fact that was an easy procedure that gave me no side effects. (I should mention that long term side effects of RT stopped my having erections, so I cannot say how HIFU would have affected me in this regard if it had been my primary treatment. However, HIFU is said to be less onerous than Surgery or Radiotherapy in this respect.) Where necessary Surgery or RT can follow Focal Treatment. As with any form of medical intervention there can be failures and a need for further treatment, so a man needs to do his research before making his decision.

          Barry
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            User
            Posted: 27 Aug 2024 at 00:16

            HIFU is one of a family of focal therapies. The others offered in the UK are cryotherapy and nanoknife.


            There are several centres offering one or more focal therapies, but none north of London as far as I know. (There is a charity Prost8 which is trying to get them rolled out further afield.)


            Focal therapies don't treat the whole prostate, only the tumours. Often they don't treat all the tumours, only the two largest, putting you on to Active Surveillance for any remaining ones. Even if all the tumours were treated, you still go back on to something like Active Surveillance for monitoring the prostate afterwards, as it's not as easy to tell if the treatment worked as it is with prostatectomy or radiotherapy.


            There are heated debates/arguments among urologists on if focal therapies are sensible treatments, some feeling strongly that they are (those who perform them), and others feeling strongly that focal therapies are not sensible curative treatments because prostate cancer isn't focal and tends to spring up in lots of places in the prostate eventually. There isn't long term data to affirm or refute these.


            If you want to know if you're eligible for a focal therapy, you will have to get a referral to a centre which does them. Urologists at centres which don't do the procedure are unlikely to give accurate info. UCLH and Imperial are the two largest who offer all the options. Some other centres offer only HIFU.

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              User
              Posted: 26 Jul 2024 at 18:33

              Hello, sorry to her this.


              Yes, max age for Prostatectomy is typically 75.


              Other options for recurrence in the prostate after radiotherapy could be:


              • Focal treatments (HIFU, Cryotherapy, Nanoknife), if the recurrence is focal.


              • There is some thought that radiation therapy again might be possible if it was previously given a long time ago, but this certainly isn't standard in the UK, and maybe not available at all.


              To pursue any of these in your special situation, you'll need to be referred to a research centre such as the London teaching hospitals.

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                User
                Posted: 04 Jul 2024 at 02:14
                Hi Gerard,

                If you are seriously considering HIFU, preferring it to other possible options, you need to go to a place where there is a specialist for it to ascertain whether you are a suitable patient. They will do a high quality scan and you will not be eligible if any cancer is observed to be outside the Prostate, in a part that cannot be reached or there is too much cancer for this type of treatment or too widely distrubuted. Before the HIFU you will also have to pass varios other pre op tests. To get pretty comperable results with surgery or radiation treatment you may well need the HIFU to be repeated as was the case with me. I had it for failed RT, the last HIFU being done in Dec 2021. (My PSA when recently tested was 0.04, nothing untoward was seen in my last MRI and I was told that I am in remission).

                I had my HIFU within a trial at UCLH in London and I beleve they now do the procedure outside a trial on the NHS. They have the most experience of the procedure in the UK and instruct others.how to perform it. They also specialize in Cryotherapy and Nanoknife, the latter being a name for Irreversable Electroporation, being other forms of Focal Therapy. I believe there are centres that do HIFU in Bristol, Southampton, Guildford and a few other places with more looking to adopt the procedure.but not difficult to get a train to Paddington and bus or taxi to UCLH and go to the most experienced.

                Lizzo is right that there is not much long term data on HIFU compared with Surgery or Radiation but clinical trials started in France in 1993 using the French Ablatherm for Prostate Cancer and it was awarded the CE mark of approval in 1999 so medium term results are known. Of course techniques have improved over time as has the equipment and one area of great benefit has been the precision afforded in recent years by the higher quality scans available. HIFU generally enables a very fast recovery with minimal side effects but if it is not able to eradicate the cancer a Prostatectomy can follow or radiation be given. However, it can made these follow up treatments more diddicult if necesssary. You have to bear in mind that all forms of treatment have their share of failurers and potential side effects.

                There is debate about how effective changing diet can be on slowing down the progress of PCa and there have been posts about this on the forum. Unfortunately, once diagnosed, a changed diet is not going to cure PCa.
                Barry
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                  User
                  Posted: 01 Jul 2024 at 18:45

                  Nanoknife is available at UCLH on the NHS for suitable candidates.


                  I wouldn't be surprised if Imperial did it too.


                  I have heard some district general hospitals are looking at offering it, but the advantage of the above is they do HIFU and Cryotherapy too, so if one focal treatment isn't suitable or not the best choice in your case, they'll know if another one would be better.

                  Edited: by member 01 Jul 2024 at 18:53  | Reason: Not specified

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                    User
                    Posted: 03 Jun 2024 at 19:10

                    Hi Paul,


                    I went to an appointment here in the UK with my brother who has prostate cancer and I mentioned Tulsa Pro.  The consultant said he was very familiar with it, said it was trialed in the UK a few years ago and the general thinking was that it was not ideal for full prostate ablation.  The reason provided was that being from the inside out it could miss cancer cells at the periphery of the organ.  Having read the material at the website, I'm not sure about this.  The consultant carries out the following procedures plus others: removal, cryotherapy and HIFU.  I'll try calling the Tulsa Pro center in the Netherlands or the Profound Medical to get their opinion on this but wanted to get your feedback.  Thanks, Harry. 

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